[CSBi-events] CSBi seminar - Dr. Ned Wingreen - April 25

[CSBi events]

Spring 2008 Seminar Series on Computational and Systems Biology

Friday, April 25, 2008

3:00 pm - 4:00 pm

Room 3-270



Presenting:

Professor Ned Wingreen

Department of Molecular Biology
Princeton University

 Title: "Modeling adaptation in E. coli chemotaxis: precise, robust, and optimized"

Abstract: The chemotaxis system of bacteria is remarkable for its sensitivity to multiple ligands, over a wide range of concentrations. These properties rely on cooperativity within clusters of receptors and on an adaptation system in which chemoreceptors are modified by methylation/demethylation. I'll discuss recent experiments that reveal new aspects of adaptation, including "assistance neighborhoods" in which tethered modifying enzymes can act on multiple receptors, and adaptive variation in the sizes of receptor clusters.

 Light refreshments to be served at 2:45 pm

 Host: Alexander van Oudenaarden, Department of Physics

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