From csbi-events at mit.edu Thu Apr 3 11:42:33 2008 From: csbi-events at mit.edu (CSBi events) Date: Thu, 3 Apr 2008 11:42:33 -0400 Subject: [CSBi-events] CSBi Seminar - Dr. Marc Vidal - April 11 In-Reply-To: <37F7BAAE-E668-45FC-88E4-1B2C87D39B00@mit.edu> References: <37F7BAAE-E668-45FC-88E4-1B2C87D39B00@mit.edu> Message-ID: <001701c895a1$5597e3b0$e4005212@DB3GWSC1> Spring 2008 Seminar Series on Computational and Systems Biology Friday, April 11, 2008 3:00 pm - 4:00 pm Room 3-270 Presenting: Dr. Marc Vidal Dana Farber Cancer Institute and Harvard Medical School Center for Cancer Systems Biology (CCSB) Title: Interactome Networks and Human Disease Abstract: For over half a century it has been conjectured that macromolecules form complex networks of functionally interacting components, and that the molecular mechanisms underlying most biological processes correspond to particular steady states adopted by such cellular networks. However, until recently, systems-level theoretical conjectures remained largely unappreciated, mainly because of lack of supporting experimental data. To generate the information necessary to eventually address how complex cellular networks relate to biology, we initiated, at the scale of the whole proteome, an integrated approach for modeling protein-protein interaction or "interactome" networks. Our main questions are: How are interactome networks organized at the scale of the whole cell? How can we uncover local and global features underlying this organization, and how are interactome networks modified in human disease, such as cancer? Light refreshments to be served at 2:45 pm Host: Alexander van Oudenaarden, Department of Physics -------------- next part -------------- An HTML attachment was scrubbed... URL: http://mailman.mit.edu/pipermail/csbi-events/attachments/20080403/82d9d716/attachment.htm -------------- next part -------------- A non-text attachment was scrubbed... Name: Announcement Poster Vidal.pdf Type: application/pdf Size: 18605 bytes Desc: not available Url : http://mailman.mit.edu/pipermail/csbi-events/attachments/20080403/82d9d716/attachment.pdf From csbi-events at mit.edu Fri Apr 11 11:08:08 2008 From: csbi-events at mit.edu (CSBi events) Date: Fri, 11 Apr 2008 11:08:08 -0400 Subject: [CSBi-events] Reminder - TODAY! CSBi Seminar - Dr. Marc Vidal In-Reply-To: <001701c895a1$5597e3b0$e4005212@DB3GWSC1> References: <37F7BAAE-E668-45FC-88E4-1B2C87D39B00@mit.edu> <001701c895a1$5597e3b0$e4005212@DB3GWSC1> Message-ID: <002c01c89be5$da301760$e4005212@DB3GWSC1> Spring 2008 Seminar Series on Computational and Systems Biology Friday, April 11, 2008 3:00 pm - 4:00 pm Room 3-270 Presenting: Dr. Marc Vidal Dana Farber Cancer Institute and Harvard Medical School Center for Cancer Systems Biology (CCSB) Title: Interactome Networks and Human Disease Abstract: For over half a century it has been conjectured that macromolecules form complex networks of functionally interacting components, and that the molecular mechanisms underlying most biological processes correspond to particular steady states adopted by such cellular networks. However, until recently, systems-level theoretical conjectures remained largely unappreciated, mainly because of lack of supporting experimental data. To generate the information necessary to eventually address how complex cellular networks relate to biology, we initiated, at the scale of the whole proteome, an integrated approach for modeling protein-protein interaction or "interactome" networks. Our main questions are: How are interactome networks organized at the scale of the whole cell? How can we uncover local and global features underlying this organization, and how are interactome networks modified in human disease, such as cancer? Light refreshments to be served at 2:45 pm Host: Alexander van Oudenaarden, Department of Physics From csbi-events at mit.edu Wed Apr 16 12:02:32 2008 From: csbi-events at mit.edu (CSBi events) Date: Wed, 16 Apr 2008 12:02:32 -0400 Subject: [CSBi-events] SAVE THE DATE: April 25th - CSBi seminar Message-ID: <003801c89fdb$47b64180$e4005212@DB3GWSC1> Spring 2008 Seminar Series on Computational and Systems Biology Friday, April 25, 2008 3:00 pm - 4:00 pm Room 3-270 Presenting: Professor Ned Wingreen Department of Molecular Biology Princeton University Title: "Interactome Modeling adaptation in E. coli chemotaxis: precise, robust, and optimized" Abstract: The chemotaxis system of bacteria is remarkable for its sensitivity to multiple ligands, over a wide range of concentrations. These properties rely on cooperativity within clusters of receptors and on an adaptation system in which chemoreceptors are modified by methylation/demethylation. I'll discuss recent experiments that reveal new aspects of adaptation, including "assistance neighborhoods" in which tethered modifying enzymes can act on multiple receptors, and adaptive variation in the sizes of receptor clusters. Light refreshments to be served at 2:45 pm Host: Alexander van Oudenaarden, Department of Physics -------------- next part -------------- An HTML attachment was scrubbed... URL: http://mailman.mit.edu/pipermail/csbi-events/attachments/20080416/f4f0cafc/attachment.htm -------------- next part -------------- A non-text attachment was scrubbed... Name: Announcement Poster Wingreen.pdf Type: application/pdf Size: 13508 bytes Desc: not available Url : http://mailman.mit.edu/pipermail/csbi-events/attachments/20080416/f4f0cafc/attachment.pdf From csbi-events at mit.edu Thu Apr 24 13:25:24 2008 From: csbi-events at mit.edu (CSBi events) Date: Thu, 24 Apr 2008 13:25:24 -0400 Subject: [CSBi-events] CSBi seminar - Dr. Ned Wingreen - April 25 Message-ID: <00be01c8a630$357aa410$f9054f12@AvO> Spring 2008 Seminar Series on Computational and Systems Biology Friday, April 25, 2008 3:00 pm - 4:00 pm Room 3-270 Presenting: Professor Ned Wingreen Department of Molecular Biology Princeton University Title: "Modeling adaptation in E. coli chemotaxis: precise, robust, and optimized" Abstract: The chemotaxis system of bacteria is remarkable for its sensitivity to multiple ligands, over a wide range of concentrations. These properties rely on cooperativity within clusters of receptors and on an adaptation system in which chemoreceptors are modified by methylation/demethylation. I'll discuss recent experiments that reveal new aspects of adaptation, including "assistance neighborhoods" in which tethered modifying enzymes can act on multiple receptors, and adaptive variation in the sizes of receptor clusters. Light refreshments to be served at 2:45 pm Host: Alexander van Oudenaarden, Department of Physics -------------- next part -------------- An HTML attachment was scrubbed... URL: http://mailman.mit.edu/pipermail/csbi-events/attachments/20080424/26c8380a/attachment.htm