[CSBi-events] Reminder, CSbi seminar October 12, 2007, (Dr. Gurol Suel)

[CSBi events]

*Reminder !  Fall 2007 Seminar Series on Computational and Systems Biology!
*
*Friday, October 12, 2007; 3:00- 4:00 PM, Rm. 4-370
Dr. Gurol Suel
UT Southwestern Medical Center *

Title:
*Noisy out of necessity: Probabilistic behavior during cellular 
differentiation. *

Light refreshments to be served at 2:45 p.m.

Host:  Dr. Alexander van Oudenaarden
Department of Physics

Abstract

Diverse organisms ranging from bacteria to mammalian stem cells undergo 
pluripotent
differentiation where a single cell can commit to one out of several 
cell fates.
How do underlying genetic circuits allow cells to "choose" a specific 
cell fate and
execute the appropriate differentiation program? To address this 
question we investigate
a simple bacterial differentiation system utilizing mathematical 
modeling and quantitative
single cell measurements. In particular we are interested in elucidating 
the significance
of circuit dynamics and stochastic behavior during cellular 
differentiation.

Suel et al. Science 315, 1716-1719 (2007)
Suel et al. Nature 440, 545-550 (2006)