From csbi-events at mit.edu  Thu Nov  8 09:55:13 2007
From: csbi-events at mit.edu (CSBi events)
Date: Thu, 08 Nov 2007 09:55:13 -0500
Subject: [CSBi-events] REMINDER:  CSBi Seminar tomorrow November 9, 2007
Message-ID: <47332351.3010604@mit.edu>

SAVE THE DATE!!!!!

Reminder !  Fall 2007 Seminar Series on Computational and Systems Biology!

Friday, November 9,2007; 3:00- 4:00 PM, Rm. 4-370
Dr. Aviv Regev
Department of Biology/The Broad Institute/MIT

Title:  Natural History and Evolutionary Principles of Gene Duplication 
in Fungi

Abstract:
Gene duplication and loss is a powerful source of functional innovation. 
However, the general principles that govern this process are still 
largely unknown. With the growing number of sequenced genomes, it is now 
possible to examine these events in a comprehensive and unbiased manner. 
Here, we develop a procedure that resolves the evolutionary history of 
all genes in a large group of species. We apply our procedure to 
seventeen fungal genomes to create a genome-wide catalogue of gene trees 
that determine precise orthology and paralogy relations across these 
species. We show that gene duplication and loss is highly constrained by 
the functional properties and interacting partners of genes. In 
particular, stress-related genes exhibit many duplications and losses, 
whereas growth-related genes show selection against such changes. 
Whole-genome duplication circumvents this constraint and relaxes the 
dichotomy, resulting in an expanded functional scope of gene 
duplication. By characterizing the functional fate of duplicate genes we 
show that duplicated genes rarely diverge with respect to biochemical 
function, but typically diverge with respect to regulatory control. 
Surprisingly, paralogous modules of genes rarely arise, even after 
whole-genome duplication. Rather, gene duplication may drive the 
modularization of functional networks through specialization, thereby 
disentangling cellular systems.

Light refreshments to be served at 2:45 p.m.

Host:  Dr. Alexander van Oudenaarden
Department of Physics
_______________________________________________
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CSBi-events at mit.edu
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From csbi-events at mit.edu  Fri Nov 30 14:36:06 2007
From: csbi-events at mit.edu (CSBi events)
Date: Fri, 30 Nov 2007 14:36:06 -0500
Subject: [CSBi-events] REMINDER
Message-ID: <20071130143606.yj1c1cqrgzwok0c4@webmail.mit.edu>



----- Forwarded message from avo1 at MIT.EDU -----
    Date: Fri, 30 Nov 2007 14:15:52 -0500
    From: Alexander van  Oudenaarden <avo1 at MIT.EDU>


Reminder: Today!



Fall 2007 Seminar Series on Computational and Systems Biology

Friday, November 30, 2007

3:00pm - 4:00pm

Room 4-370



Presenting:
Dr. Pamela Silver
Department of Systems Biology/Harvard Medical School


Title:  Designing Biological Systems
Abstract: Biology presents us with an array of design principles.   We are
interested in using the foundations of biology to engineer cells in a logical
way to perform certain functions. In doing so, we learn more about the
fundamentals of biological design as well as engineer useful devices with a
myriad of applications.  For example, we are interested in combining
transcription-based with post-transcriptional logic such as protein
localization and degradation to build cells that can perform specific tasks,
such as counting mitotic divisions, measuring life span and remembering past
events.   I will discuss the successful design and construction of aeukaryotic
system with predictable biological properties as well as a novel synthetic
protein platform for altering cell behavior.  I will also discuss the logical
design of bio-systems for regulation of metabolic pathways.

Light refreshments to be served at 2:45 p.m.

Host:  Dr. Alexander van Oudenaarden
Department of Physics
_______________________________________________
CSBi-events mailing list
CSBi-events at mit.edu
http://mailman.mit.edu/mailman/listinfo/csbi-events


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