[CSBi-events] Invitation to CSBi Symposium

[CSBi events]

Colleagues,

We are writing to invite you to the 2007 CSBi Symposium "Discovery,  
Design & Development of Human Drugs and Therapeutics" on Jan 31,  
2007. Because the corporate support for this year’s event has been  
overwhelming, we have decided to waive the registration fee for  
anyone with an MIT ID.  Please contact Linda Earle (lkn at mit.edu) for  
a free code to register on-line (http://csbi.mit.edu)

To kick-off the symposium, we are hosting a poster session and  
reception at 5-7 pm on Tuesday January 30 in the Biology Koch  
Building (68-180/181).

The symposium will take place on Wednesday January 31. A world-class  
group of scientists will describe the research that leads to the  
development of small molecule drugs and protein therapeutics.

The morning session, "From Systems Designs to Protein Therapeutics"  
will begin with Jim Wells (UCSF) talking about "Site-Directed  
Chemistry and Signaling in Caspases". Afterwards, Tillman Gerngross  
(Dartmouth) will describe how the human glycosylation pathway was  
introduced into yeast in his talk "Humanized Yeast: A Tool to Dissect  
the Glycomics Space". The session will end with Bruce Tidor and Doug  
Lauffenburger (MIT) teaming to present jointly their research on the  
systems analysis of growth factor recycling and computational  
engineering of factors with improved efficacy "Therapeutic Discovery  
in Context: Framing a Bigger Picture".

Frank Douglas of the Center for Biomedical Innovation will chair the  
afternoon session. Liping Zhao (Shanghai) will discuss the systems  
analysis of Traditional Chinese Medicine treatments "Integration of  
Metabonomics and Metagenomics for Understanding Human Organismal  
Level Complexity". This talk will be contrasted by the Western  
Medicine approaches in "System Level Biomarker Profiles of Drug  
Treatments for Diabetics/Hypertension" by Aram Adourian (BG  
Medicine). Finally, the afternoon will end with a discussion of  
Parkinson's Disease. Susan Lindquist (Whitehead Institute) will  
describe the research in her lab on the misfolding of alpha-synuclein  
"Yeast as a Discovery Platform for Neurodegenerative Disease" while  
Erik Wanker (Berlin) will approach the same disease through a network  
approach "Generation of Interaction Networks for Understanding  
Neurodegenerative Disease Processes".

For other information you can contact: Linda Earle (lkn at mit.edu).

Sincerely,

The Organizing Committee (Noubar Afeyan, Susan Lindquist, Paul  
Matsudaira, Edward Scolnick, Anthony Sinskey, and Bruce Tidor)