[CSBi-events] CSBi Speaker Series - Dr. Dan Herschlag 12/2/05

[csbi-events@mit.edu]

Dear CSBi Community,

You may want to take note of the upcoming seminar on Friday, December 
2.  Thank you.

Dr. Daniel Herschlag
Stanford University
Department of Biochemistry, Beckman Center

The Logic of Gene Expression: 
A Global View of RNA Processing

Friday, December 2, 2005
Maclaurin Building (4-270)
3:00 - 4:00 p.m.
Light refreshments served.

Abstract
In the post-genome era, understanding the gene expression program 
looms as a central fundamental challenge in unraveling the 
complexities and organization of biological systems. Considerable 
efforts utilizing whole-genome approaches have revealed complex yet 
elegant mechanisms for control and coordination at the 
transcriptional level. Yet a multitude of RNA processing steps occur 
post-transcriptionally, and these steps, involving both association 
with RNA-binding proteins and covalent modifications of mRNA and 
other RNAs, must be dissected to develop and a comprehensive and deep 
understanding of the mechanisms of gene expression. I will describe 
our initial global studies of RNA processing events that reveal and 
suggest aspects of the logic that underlies the gene expression 
program.

References
Wang, Y., Liu, C. L., Storey, J. D., Tibshirani, R. J., Herschlag, D. 
and Brown, P. O. (2002) "Precise and Functional Specificity in mRNA 
Decay." Natl. Acad. Sci. USA 99, 5860-5865.

Arava, Y., Wang, Y., Storey, J. D., Liu, C. L., Brown, P. O. and 
Herschlag, D. (2003) "Genome-wide Analysis of mRNA Translation 
Profiles in Saccharomyces cerevisiae." Proc. Natl. Acad. Sci. USA 
100, 3889-3894.

106. Gerber, A. P., Herschlag, D. and Brown, P. O. (2004) "Extensive 
Association of Functionally and Cytotopically Related mRNAs with 
Puf-family RNA-binding Proteins in Yeast." PLoS Biology. 2, 0342-0354.

Host: Dr. David Bartel
Biology Department
Contact:  Laura Resteghini 
						617.258.7778
http://csbi.mit.edu/
Sponsored by  CSBi
Annual CSBi Seminar Series in Computational and Systems Biology
The entire MIT Community is welcome to attend!

Directions can be found at the following url:
http://whereis.mit.edu/map-jpg

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