From csbi-events at mit.edu Wed Feb 2 09:28:31 2005 From: csbi-events at mit.edu (csbi-events@mit.edu) Date: Wed, 02 Feb 2005 09:28:31 -0500 Subject: [CSBi-events] LIDS Colloquium - Tues. February 8 Message-ID: <5.2.1.1.2.20050202092554.02df1e48@po14.mit.edu> ------------------------------------------------------------------ L I D S C O L L O Q U I U M LABORATORY FOR INFORMATION AND DECISION SYSTEMS ------------------------------------------------------------------ CHALLENGES IN THE COMPUTATIONAL STRUCTURAL BIOLOGY OF VIRUSES Peter C. Doerschuk Electrical and Computer Engineering Purdue University Tuesday, February 8, 2005 4:00-5:00 pm 32-124 A short reception will follow on the 6th floor of the Dreyfoos Tower Abstract: --------- Structural biology is an important area of biology, both pure and applied. The computational aspects of structural biology pose challenges in areas that are longstanding research interests of EECS, e.g., statistical estimation, pattern classification, and nonlinear programming. The success of high-throughput genetic sequencing and the similar, though not as far advanced, success of high-throughput protein structure determination by x-ray crystallography and nuclear magnetic resonance imply that an important frontier of structural biology concerns challenges related to the interactions of multiple macromolecular molecules in what are essentially nano-machines. In this talk, some of these challenges will be described and results concerning the structural biology of viruses will be used as illustrations of the types of systems, control, and signal processing problems that arise. Biography: ---------- Peter Doerschuk is a Professor of Electrical and Computer Engineering and Biomedical Engineering at Purdue University. He received BSEE, MSEE, and PhD degrees from MIT in EECS in 1977, 1979, and 1985, respectively and an MD degree from Harvard Medical School (HST) in 1987. After a postdoc at LIDS he joined Purdue in 1990. His research interests are in computational biology and a variety of areas in estimation, dynamical systems, and computation motivated by computational biology requirements. -- Dawn Davis Loring Communications Coordinator Computational and Systems Biology (CSBi) Phone: (617) 324-0150 Fax: (617) 324-0081 Massachusetts Institute of Technology 77 Massachusetts Avenue Building 68 - Room 459 Cambridge, MA 02139 From csbi-events at mit.edu Tue Feb 22 11:16:02 2005 From: csbi-events at mit.edu (csbi-events@mit.edu) Date: Tue, 22 Feb 2005 11:16:02 -0500 Subject: [CSBi-events] Jacobian Seminar - Release 2.0 Features Message-ID: <5.2.1.1.2.20050222111157.02d35b98@po14.mit.edu> Jacobian Computational and Systems Biology Modeling Software - Seminar on Release 2.0 Features DATE: Friday, March 4, 2005 TIME: 1:00 ? 3:00 p.m. (Refreshments from 3:00-4:00 PM) LOCATION: MIT Campus Bldg 1 Room 135 1:00 to 1:15pm: Coffee & refreshments 1:15 to 1:50pm: Introduction to new Jacobian users Model building, validation and application/deployment will be presented using simple examples taken from signal pathway model. This part of the seminar is intended for those who are new to Jacobian software. 1:50 to 2:00pm: Break 2:00 to 3:00pm: New features of Jacobian Release 2 Presentations will include the following new features: a) Model analysis environment to check if the problem is well-posed and, if not, assist the user in correcting the model b) Greater output information from parameter estimation such as Variance, Correlation and Fisher information Matrix, and Confidence Ellipses c) Jacobian API to interface with external software such as MS-Excel d) Jacobian External to connect other programs, such as legacy codes, to a Jacobian model e) Examples of translating models from SBML into Jacobian f) Instructions on how to obtain Jacobian Release 2 3:00 pm-4:00pm: Refreshments. Numerica staff will be available to answer questions For further information, please contact Glen Ko at: ghk at numericatech.com Sponsored by MIT?s Computational & Systems Biology initiative Dawn Davis Loring Communications Coordinator Computational and Systems Biology (CSBi) Phone: (617) 324-0150 Fax: (617) 324-0081 Massachusetts Institute of Technology 77 Massachusetts Avenue Building 68 - Room 459 Cambridge, MA 02139