[CSBi-events] CSBi Seminar: "Rational Design of DNA Machines"

[csbi-events@mit.edu]

"Rational Design of DNA Machines"

Dr. Niles A. Pierce
California Institute of Technology

Friday, May 6, 2005
3-270
3:30-4:30 p.m.

Abstract
Single-stranded DNA is a versatile construction material that can be 
programmed to self-assemble into nanoscale devices driven by the free 
energy of base pair formation. Rational sequence design methods based on 
efficient partition function algorithms permit simultaneous optimization of 
affinity and specificity for target secondary structures that define the 
function of a device. These methods have been used to engineer a synthetic 
DNA walker that mimics the gait of kinesin and a class of biosensors based 
on the mechanism of hybridization chain reaction.

Host: Bruce Tidor
Contact: Brenda Pepe, 2-3885
http://csbi.mit.edu
Sponsored by CSBi

Annual CSBi Seminar Series in Computational and Systems Biology


Dawn Davis Loring
Communications Coordinator
Computational and Systems Biology (CSBi)
Phone: (617) 324-0150
Fax: (617) 324-0081

Massachusetts Institute of Technology
77 Massachusetts Avenue
Building 68 - Room 459
Cambridge, MA 02139