[CSBi-events] Seminar: From Mouse Genetics to Human Therapeutics

[csbi-events@mit.edu]

Hi,

I am out of office from thursday (18) afternoon to friday (19). In case 
of urgency, you can reach my cell at 617-259-7388.

-Ashwani




On Nov 5, 2004, at 10:27 AM, csbi-events at MIT.EDU <csbi-events at MIT.EDU> 
wrote:

> From Mouse Genetics to Human Therapeutics
>
> Time: Wednesday (11/10/04) at 4:00 PM
> Location: 68-181
>
> Gary Peltz, M.D., Ph.D
>
> Department of Genetics and Genomics
> ROCHE, Palo Alto, CA
>
>
> Our understanding of genetic factors effecting human disease
> susceptibility and the response to drug treatment is advanced by
> analysis of murine genetic models.  As one example, a murine genetic
> model of osteoporosis was analyzed, and a novel pathway regulating bone
> development was identified.  However, a significant amount of time and
> cost is associated with the conventional methods used for mouse genetic
> analysis.  A novel computational method was developed to reduce the 
> time
> and cost required for mouse genetic analysis.  This method identifies a
> causative genetic factor by correlating a pattern of observable
> physiological or pathological differences among selected strains of 
> mice
> with the pattern of genetic variation. A haplotypic map of the genome,
> based upon 150,000 SNPs identified from analysis of 1,900 genes across
> 20 commonly used laboratory mouse strains (http://mouseSNP.roche.com),
> was produced.  This map was used to develop a method for rapid,
> haplotype-based, computational identification of the genetic basis for
> observed physiologic and pathologic differences among inbred strains.
> This computational method correctly predicted the genetic basis for
> strain-specific differences in multiple biologically important
> phenotypic traits, and was used to identify a novel allele-specific
> enhancer element regulating H2-Ea expression.  This method is now being
> used to analyze the mechanism of action and metabolism of a commonly
> prescribed medication.
>
> References
>
> In silico genetics: identification of a functional element
> regulating H2-Ealpha gene expression. Science  306:690, 2004
>
> Regulation of bone mass in mice by the lipoxygenase gene Alox15. 
> Science
> 303:229, 2004
>
> Contact:
> Peter Sandy, Ph.D.
> Center for Cancer Research
> Tel: 617-324-8700
> Email: psandy at mit.edu
>
> PLEASE DO NOT RESPOND TO THIS EMAIL, SEE CONTACT INFO ABOVE.
>
> Dawn Davis Loring
> Communications Coordinator
> Computational and Systems Biology (CSBi)
> Phone: (617) 324-0150
> Fax: (617) 324-0081
>
> Massachusetts Institute of Technology
> 77 Massachusetts Avenue
> Building 68 - Room 459
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