[CSBi-events] APPLIED MATHEMATICS COLLOQUIUM (Joint with Bioinformatics Seminar)

[Dawn Davis Loring]

 From Amy Keating:

APPLIED MATHEMATICS COLLOQUIUM  (Joint with Bioinformatics Seminar)

FOLDING ALGORITHMS FOR PROTEIN STRUCTURE PREDICTION

DATE:  MONDAY, FEBRUARY 23, 2004
TIME:     4:15 PM
LOCATION:  Building 2, Room 105

Reception at 3:30 PM in Building 2, Room 349.

Guest:  PHILIP BRADLEY, University of Washington

ABSTRACT:
To reach their biologically active state, newly synthesized proteins
spontaneously fold from an extended, linear conformation into a compact
three-dimensional structure.

This remarkable self-assembly process, protein folding, is guided by the
amino acid sequence of the protein to a unique final state. Despite
several decades of intensive study the process by which sequence
determines structure is still not well understood; in particular it is not
currently possible to predict a protein's native three-dimensional
structure given only its sequence.  Recently, however, a class of
prediction algorithms based on protein fragment assembly have made
considerable headway towards the goal of generating low-resolution
structure predictions. In this talk I will introduce the protein folding
problem, describe these new algorithms, highlight their strengths and
weaknesses, and discuss current research directed at improving the
reliability and accuracy of their predictions.


Dawn Davis Loring
Communications Coordinator
Computational and Systems Biology (CSBi)
Phone: (617) 324-0150
Fax: (617) 324-0081

Massachusetts Institute of Technology
77 Massachusetts Avenue
Building 68 - Room 459
Cambridge, MA 02139
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