[Crib-list] SPEAKER: Ashlee N. Ford Versypt (MIT) -- "Computational Research in Boston and Beyond Seminar" -- Friday, April 5, 2013 -- TIME: 12:00 Noon in Building 32, Room 141

[Shirley Entzminger]

 		   COMPUTATIONAL RESEARCH in BOSTON and BEYOND Seminar


DATE:		Friday, April 5, 2013
TIME:		12:00 Noon
LOCATION:	Building 32, Room 141 (Stata Center)
 		32 Vassar Street, Cambridge


(Pizza provided at 11:45 AM outside Room 32-141.)


SPEAKER:	Ashlee N. Ford Versypt  (M.I.T.)


TITLE:		Mathematical Modeling of Pharmaceuticals:
 		Predictive Design for Better Medicines


ABSTRACT:

Smart designs of drug molecules and pharmaceutical formulations can target 
treatments to specific tissues, reduce side effects, and improve patient 
quality of care. Computational models for evaluating pharmaceutical 
formulations can narrow the range of experiments needed to identify 
successful designs by predicting performance and thus reducing the 
development time and driving down costs. Models coupled with sophisticated 
process control strategies allow for careful monitoring of manufacturing 
to reduce wasted materials and energy and to adhere to quality standards. 
I will overview mathematical modeling efforts in several pharmaceutical 
domains and will highlight work related to predicting drug release from 
controlled-release formulations that administer medicine over extended 
periods with a single dosage. I will show how coupled, nonlinear partial 
differential equations can be used to capture the complex dynamic 
interactions between simultaneous chemical reactions and mass transfer. I 
will describe mathematical techniques that can be used to reduce the 
system size from thousands of equations to just a few while retaining 
resolution of the biodegradation of the pharmaceutical formulation that 
strongly influences the drug release dynamics. These techniques can aid in 
the design of new controlled-release formulations.

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Massachusetts Institute of Technology
Cambridge, MA


For information, please visit...

 			http://math.mit.edu/crib/