[bioundgrd] FW: Looking for a UROP student

[Joshua Stone]

From: Jordan Ray <gjray at mit.edu>
Subject: Looking for a UROP student

Term: Fall & Spring

UROP Department, Lab or Center: Whitehead Institute, Biology (Course 7)

MIT Faculty Supervisor Name: David Sabatini

Project Title:  Understanding the role of the lysosome in RNA degradation


Project Description:
Autophagy is a process by which cells can induce the degradation of specific macromolecules by targeting them to the lysosome. In the Sabatini lab, we have created a novel method to rapidly purify lysosomes. Using this method, we are now characterizing substrates of autophagy, particularly novel RNAs that are degraded in the lysosome. Understanding this process will elucidate both how certain cancers hijack autophagy to gain more nutrients, and also what leads to lysosome dysfunction in aging and neurodegeneration.

The Sabatini lab is looking for a student who is interested in biochemistry, metabolism, and cancer research to assist with this project.  This opportunity is offered for the Fall and Spring terms with possibility for continuation during next summer.  The student will learn a variety of techniques including mammalian cell culture, protein purification and various types of biochemical assays.

If interested, please send your CV/resume and detail any experience or course work you have had with molecular biology and experimental biology.


  *   Academic year 2019/2020
  *   Direct Supervisor: Jordan Ray

Prerequisites:

  *   Cell culture experience
  *   Good communication and organizational skills
  *   Background in experimental and molecular biology
  *   Interest in pursuing a graduate degree in the life sciences is considered a plus

Contact: Jordan Ray (gjray at mit.edu)




--
G. Jordan Ray
Biology PhD Candidate, Sabatini Lab
Massachusetts Institute of Technology
gjray at mit.edu<mailto:gjray at mit.edu>
(240) 731-4516
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