[bioundgrd] UROP Opportunity in Ploegh Lab/Whitehead Institute

[Joyce Roberge]

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Non-invasive Imaging of Immune Responses
Myeloid cells, such as neutrophils, dendritic cells and activated macrophages express CD11b and/or Class II MHC products and are often present at the tumor margin. The ability to image myeloid cells’ presence is thus of diagnostic relevance and may be an approach more generally applicable than detection of tumor cells bearing unique tumor-specific markers. Current practice either relies on sampling of peripheral blood to enumerate and characterize these cells in the circulation, or requires more invasive procedures, such as histological analysis of biopsies or surgical resection specimens. Given the recent successes in the application of antibodies that target immunological checkpoints, there is an urgent need to monitor the progress of such immunotherapies, and to be able to do so non-invasively.
The project involves: protein expression, purification and modification, cell work, LC-MS, HPLC, FPLC, flow cytometery, two photon imaging, and PET imaging.
Students will be trained for the techniques. Interested students can contact Dr. Rashidian at mohamadr at mit.edu<mailto:mohamadr at mit.edu>
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