[bioundgrd] Fwd: UROP Opening - Protein Engineering for Emerging Therapeutic and Biological Applications

[MacKenzie Outlund]

----------------------------------

UROP Department/Lab/Center: HST/BE

Faculty Supervisor: Ram Sasisekharan

Project Title: Protein Engineering for Emerging Therapeutic and Biological
Applications

Project Description: The aim of this research is to develop an in-house
protein
engineering protocol for the high-throughput construction and testing of
novel
biomolecules that are being designed for therapeutic applications ranging
from
infectious diseases to cancer (see lab website for recent publications --
http://web.mit.edu/tox/sasisekharan/publications/pubs2009.html).

Prerequisites: The UROP is ideal for advanced Course 7/Course 20/Course
9/Course
10/Course 5/HST majors with substantial prior experience in experimental
protein
engineering techniques, specifically, (a.) high-throughput protein
expression
using bacterial or mammalian systems, (b.) purification, and (c.) binding
assays for quantitative analysis of biomolecular interactions. Experience
with
these techniques may have been gained through a combination of hands-on wet
lab
work and previous UROPs. Additionally, students interested in the following
applications are particularly encouraged to apply for this position --
antibody
engineering, immunotherapeutics, protein library design, site-directed
mutagenesis, circular dichroism (CD) spectral analysis, nuclear magnetic
resonance (NMR) or crystallization of proteins, analysis of biomolecular
structure-function relationships, and molecular modeling tools for
design-based
engineering.

Contact: Interested students can e-mail a brief statement of interest with
enclosed resume/CV to Venkat Soundararajan (venk at mit.edu) with a copy to Ram
Sasisekharan (rams at mit.edu).

----------------------------------
-------------- next part --------------
An HTML attachment was scrubbed...
URL: http://mailman.mit.edu/pipermail/bioundgrd/attachments/20090916/72e9a94c/attachment.htm