[bioundgrd] Summer UROP position in Prof. Peter Reddien's lab

[Janice Chang]

>
>UROP position
>Summer 2007
>Biology and Whitehead Institute
>Faculty Supervisor: Peter Reddien
>
>There is an opening for a summer UROP position in the Reddien lab at 
>the Whitehead Institute in the Biology Department. The ability to 
>regenerate missing body parts is one of the great mysteries of 
>biology. The Reddien lab studies regeneration in planarians: an 
>emerging molecular genetic system in which RNA interference can be 
>utilized and many molecular resources are available. Regeneration is 
>accomplished via the action of a population of stem cells called 
>neoblasts. This project relates to the characterization of 
>monoclonal antibodies that recognize planarian proteins. 
>Specifically, hybridomas created from mice immunized with planarian 
>cells or proteins exist and are being screened for production of 
>antibodies recognizing planarian proteins and cells using a 
>microarray-based, high-throughput approach.  Existing positive 
>clones will be screened with fluorescent antibody labelings for 
>labeling patterns in animals or on isolated cells. Further screens 
>will be performed for monoclonal antibodies to specific proteins of 
>interest in the lab. Goals include development of markers for the 
>planarian stem cells and markers for other tissues and cell types 
>for phenotypic analyses.
>
>Prerequisites: Familiarity with basic cell and molecular biology. 
>7.02 preferred, but not required.
>
>Contact: reddien at wi.mit.edu
>http://inside.wi.mit.edu/reddien/pub/PWR_website/Rddn_home.html
>