[Bioundgrd] UROP Position

[Kathleen Long]

>>Project Title: Genome-wide mutation analysis of a lung cancer mouse model
>>
>>Project Description: Accurate mouse models of human cancer are 
>>important tools to study tumor biology and to test therapeutics. 
>>Lung cancer is the leading cause of cancer deaths worldwide. To 
>>better understand the disease, our lab has genetically engineered a 
>>few mutations in mice to allow the initiation of lung cancer. This 
>>project will analyze the additional mutations that arise across the 
>>genome of our mice as lung cancer develops. At the end of the 
>>project, we will attempt to pinpoint the critical genetic 
>>components in lung cancer by comparing our results to the mutations 
>>known in human patients.
>>
>>Specifically, the UROP student will be supervised by a graduate student to:
>>1) develop a database to store and analyze results
>>2) design and perform assays to map mutations by genotyping single 
>>nucleotide polymorphisms (SNPs)
>>
>>Prerequisites: The students should have good programming skills. 
>>Familiarity with FileMaker is desired. Interest in biology is 
>>required but no experience is necessary. This project is an 
>>excellent opportunity for a computer science student to gain 
>>hands-on experience in biology, or for a biology student to expand 
>>his/her computer skill sets.
>>
>>Contact: To discuss this UROP position, please contact Mandy Tam at 
>>mtam at mit.edu