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<p class=MsoNormal><span style='font-size:14.0pt;color:black'>[Please note
updated time and location]<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:14.0pt;color:black'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:14.0pt;color:black'>Please join us
November 1 for a talk by our friend and colleague Victor McElheny:</span><span
style='font-size:10.5pt;font-family:Consolas;color:black'><o:p></o:p></span></p>
<p class=MsoNormal><b><span style='font-size:14.0pt;color:black'> </span></b><span
style='font-size:10.5pt;font-family:Consolas;color:black'><o:p></o:p></span></p>
<p class=MsoNormal><b><span style='font-size:14.0pt;color:black'>Genomic
History: Open Items</span></b><span style='font-size:10.5pt;font-family:Consolas;
color:black'><o:p></o:p></span></p>
<p class=MsoNormal><span style='color:black'> </span><span
style='font-size:10.5pt;font-family:Consolas;color:black'><o:p></o:p></span></p>
<p class=MsoNormal><b><span style='color:black'>DATE:
Monday, November 1</span></b><b><span style='font-size:10.5pt;font-family:Consolas;
color:black'><o:p></o:p></span></b></p>
<p class=MsoNormal><b><span style='color:black'>TIME:
4:00pm-6:00pm</span></b><b><span style='font-size:10.5pt;font-family:Consolas;
color:black'><o:p></o:p></span></b></p>
<p class=MsoNormal><b><span style='color:black'>ROOM:
</span></b><b>E51-275<span style='color:black'><br>
</span></b><span style='color:black'><br>
<br>
</span><span style='font-size:10.5pt;font-family:Consolas;color:black'><o:p></o:p></span></p>
<p class=MsoNormal><span style='color:black'>An abstract from Victor:</span><span
style='font-size:10.5pt;font-family:Consolas;color:black'><o:p></o:p></span></p>
<p class=MsoNormal><span style='color:black'> Just finishing a survey of
the history of the 20-year-old Human Genome Project and its immediate
results (Drawing the Map of Life, </span><span style='font-size:10.5pt;
font-family:Consolas;color:black'><o:p></o:p></span></p>
<p class=MsoNormal><span style='color:black'>Basic Books, 2010) makes me
acutely conscious of the large number of unanswered or partly answered
questions relating to this immense and still unfolding aspect of
contemporary biology. Several of these concern the origins of what many
thought was an improbable enterprise: <o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:10.5pt;font-family:Consolas;
color:black'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='color:black'>1) the relative influence of
technical advances, 2) discoveries of gene-related diseases, 3) the
political experience of the “War on </span><span style='font-size:
10.5pt;font-family:Consolas;color:black'><o:p></o:p></span></p>
<p class=MsoNormal><span style='color:black'>Cancer” and the recombinant
DNA controversy in the 1970s, 4) the difficulty in measuring environmental
sources of cancer, and 5) the </span><span style='font-size:10.5pt;
font-family:Consolas;color:black'><o:p></o:p></span></p>
<p class=MsoNormal><span style='color:black'>desire to demonstrate the medical
utility of molecular biology. Among other open items: 1) the
technologically conservative choice to use </span><span style='font-size:
10.5pt;font-family:Consolas;color:black'><o:p></o:p></span></p>
<p class=MsoNormal><span style='color:black'>existing DNA sequencing technology
for the big push to the first complete human sequence; 2) detailed
management of the global non-</span><span style='font-size:10.5pt;font-family:
Consolas;color:black'><o:p></o:p></span></p>
<p class=MsoNormal><span style='color:black'>profit human genome consortium,
evidenced in multi-time-zone Friday teleconferences of which extensive
notes exist; 3) the technical </span><span style='font-size:10.5pt;
font-family:Consolas;color:black'><o:p></o:p></span></p>
<p class=MsoNormal><span style='color:black'>evolution of the profusion of
competing “next generation” sequencing machines that are
bringing the day of $1,000 human genomes very close; 4) the influence of
ethical concerns on the course of the project; and 5) controversy over the
relative role of rare or common variants in increasing or decreasing an
individual’s risks of disease. All this points to the need, in the
fairly near future, of a comprehensive </span><span style='font-size:10.5pt;
font-family:Consolas;color:black'><o:p></o:p></span></p>
<p class=MsoNormal><span style='color:black'>history of genomics, probably by
multiple authors. Could this be ready by the 25th anniversary of the
project in 2015?</span><span style='font-size:10.5pt;font-family:Consolas;
color:black'><o:p></o:p></span></p>
<p class=MsoNormal><span style='color:black'> </span><span
style='font-size:10.5pt;font-family:Consolas;color:black'><o:p></o:p></span></p>
<p class=MsoNormal><span style='color:black'>Speaker. Victor McElheny, a
science journalist since 1957, was founding director of STS’
daughter program, the Knight Science </span><span style='font-size:10.5pt;
font-family:Consolas;color:black'><o:p></o:p></span></p>
<p class=MsoNormal><span style='color:black'>Journalism Fellowships, from 1982
to 1998, when he became an STS Visiting Scholar. Since then, he as
published three books, Insisting </span><span style='font-size:10.5pt;
font-family:Consolas;color:black'><o:p></o:p></span></p>
<p class=MsoNormal><span style='color:black'>on the Impossible, The Life of
Edwin Land, Inventor of Instant Photography (Perseus, 1998); Watson and
DNA: Making a Scientific </span><span style='font-size:10.5pt;font-family:
Consolas;color:black'><o:p></o:p></span></p>
<p class=MsoNormal><span style='color:black'>Revolution (Perseus 2003); and
Drawing the Map of Life: Inside the Human Genome Project (Basic Books,
2010). Earlier he was a staff </span><span style='font-size:10.5pt;
font-family:Consolas;color:black'><o:p></o:p></span></p>
<p class=MsoNormal><span style='color:black'>reporter for the Charlotte (NC)
Observer, Science magazine, the Boston Globe, and the New York Times,
covering such topics as science in </span><span style='font-size:10.5pt;
font-family:Consolas;color:black'><o:p></o:p></span></p>
<p class=MsoNormal><span style='color:black'>Antarctica, the nuclear energy
program of India, the Apollo lunar landing program, and, starting in 1960,
advances in biological </span><span style='font-size:10.5pt;font-family:
Consolas;color:black'><o:p></o:p></span></p>
<p class=MsoNormal><span style='color:black'>science. In 1978-82, he was the
first director of the Banbury Center of Cold Spring Harbor Laboratory.</span><span
style='font-size:10.5pt;font-family:Consolas;color:black'><o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif"'><o:p> </o:p></span></p>
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