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<p class=MsoPlainText><span style='font-size:14.0pt;font-family:"Times New Roman","serif"'>Please
join us November 1 for a talk by our friend and colleague Victor McElheny:<o:p></o:p></span></p>
<p class=MsoPlainText><b><span style='font-size:14.0pt;font-family:"Times New Roman","serif"'><o:p> </o:p></span></b></p>
<p class=MsoPlainText><b><span style='font-size:14.0pt;font-family:"Times New Roman","serif"'>Genomic
History: Open Items<o:p></o:p></span></b></p>
<p class=MsoPlainText><span style='font-size:12.0pt;font-family:"Times New Roman","serif"'>
<o:p></o:p></span></p>
<p class=MsoPlainText><span style='font-size:12.0pt;font-family:"Times New Roman","serif"'>DATE:
Monday, November 1<o:p></o:p></span></p>
<p class=MsoPlainText><span style='font-size:12.0pt;font-family:"Times New Roman","serif"'>TIME:
4:30pm-6:30pm<o:p></o:p></span></p>
<p class=MsoPlainText><span style='font-size:12.0pt;font-family:"Times New Roman","serif"'>ROOM:
E51-149<br>
<br>
<o:p></o:p></span></p>
<p class=MsoPlainText><span style='font-size:12.0pt;font-family:"Times New Roman","serif"'>An
abstract from Victor:<o:p></o:p></span></p>
<p class=MsoPlainText><span style='font-size:12.0pt;font-family:"Times New Roman","serif"'>
Just finishing a survey of the history of the 20-year-old Human <o:p></o:p></span></p>
<p class=MsoPlainText><span style='font-size:12.0pt;font-family:"Times New Roman","serif"'>Genome
Project and its immediate results (Drawing the Map of Life, <o:p></o:p></span></p>
<p class=MsoPlainText><span style='font-size:12.0pt;font-family:"Times New Roman","serif"'>Basic
Books, 2010) makes me acutely conscious of the large number of <o:p></o:p></span></p>
<p class=MsoPlainText><span style='font-size:12.0pt;font-family:"Times New Roman","serif"'>unanswered
or partly answered questions relating to this immense and <o:p></o:p></span></p>
<p class=MsoPlainText><span style='font-size:12.0pt;font-family:"Times New Roman","serif"'>still
unfolding aspect of contemporary biology. Several of these <o:p></o:p></span></p>
<p class=MsoPlainText><span style='font-size:12.0pt;font-family:"Times New Roman","serif"'>concern
the origins of what many thought was an improbable enterprise: <o:p></o:p></span></p>
<p class=MsoPlainText><span style='font-size:12.0pt;font-family:"Times New Roman","serif"'>1)
the relative influence of technical advances, 2) discoveries of <o:p></o:p></span></p>
<p class=MsoPlainText><span style='font-size:12.0pt;font-family:"Times New Roman","serif"'>gene-related
diseases, 3) the political experience of the “War on <o:p></o:p></span></p>
<p class=MsoPlainText><span style='font-size:12.0pt;font-family:"Times New Roman","serif"'>Cancer”
and the recombinant DNA controversy in the 1970s, 4) the <o:p></o:p></span></p>
<p class=MsoPlainText><span style='font-size:12.0pt;font-family:"Times New Roman","serif"'>difficulty
in measuring environmental sources of cancer, and 5) the <o:p></o:p></span></p>
<p class=MsoPlainText><span style='font-size:12.0pt;font-family:"Times New Roman","serif"'>desire
to demonstrate the medical utility of molecular biology. Among <o:p></o:p></span></p>
<p class=MsoPlainText><span style='font-size:12.0pt;font-family:"Times New Roman","serif"'>other
open items: 1) the technologically conservative choice to use <o:p></o:p></span></p>
<p class=MsoPlainText><span style='font-size:12.0pt;font-family:"Times New Roman","serif"'>existing
DNA sequencing technology for the big push to the first <o:p></o:p></span></p>
<p class=MsoPlainText><span style='font-size:12.0pt;font-family:"Times New Roman","serif"'>complete
human sequence; 2) detailed management of the global non- <o:p></o:p></span></p>
<p class=MsoPlainText><span style='font-size:12.0pt;font-family:"Times New Roman","serif"'>profit
human genome consortium, evidenced in multi-time-zone Friday <o:p></o:p></span></p>
<p class=MsoPlainText><span style='font-size:12.0pt;font-family:"Times New Roman","serif"'>teleconferences
of which extensive notes exist; 3) the technical <o:p></o:p></span></p>
<p class=MsoPlainText><span style='font-size:12.0pt;font-family:"Times New Roman","serif"'>evolution
of the profusion of competing “next generation” sequencing <o:p></o:p></span></p>
<p class=MsoPlainText><span style='font-size:12.0pt;font-family:"Times New Roman","serif"'>machines
that are bringing the day of $1,000 human genomes very close; <o:p></o:p></span></p>
<p class=MsoPlainText><span style='font-size:12.0pt;font-family:"Times New Roman","serif"'>4)
the influence of ethical concerns on the course of the project; and <o:p></o:p></span></p>
<p class=MsoPlainText><span style='font-size:12.0pt;font-family:"Times New Roman","serif"'>5)
controversy over the relative role of rare or common variants in <o:p></o:p></span></p>
<p class=MsoPlainText><span style='font-size:12.0pt;font-family:"Times New Roman","serif"'>increasing
or decreasing an individual’s risks of disease. All this <o:p></o:p></span></p>
<p class=MsoPlainText><span style='font-size:12.0pt;font-family:"Times New Roman","serif"'>points
to the need, in the fairly near future, of a comprehensive <o:p></o:p></span></p>
<p class=MsoPlainText><span style='font-size:12.0pt;font-family:"Times New Roman","serif"'>history
of genomics, probably by multiple authors. Could this be ready <o:p></o:p></span></p>
<p class=MsoPlainText><span style='font-size:12.0pt;font-family:"Times New Roman","serif"'>by
the 25th anniversary of the project in 2015?<o:p></o:p></span></p>
<p class=MsoPlainText><span style='font-size:12.0pt;font-family:"Times New Roman","serif"'><o:p> </o:p></span></p>
<p class=MsoPlainText><span style='font-size:12.0pt;font-family:"Times New Roman","serif"'><o:p> </o:p></span></p>
<p class=MsoPlainText><span style='font-size:12.0pt;font-family:"Times New Roman","serif"'><o:p> </o:p></span></p>
<p class=MsoPlainText><span style='font-size:12.0pt;font-family:"Times New Roman","serif"'>Speaker.
Victor McElheny, a science journalist since 1957, was <o:p></o:p></span></p>
<p class=MsoPlainText><span style='font-size:12.0pt;font-family:"Times New Roman","serif"'>founding
director of STS’ daughter program, the Knight Science <o:p></o:p></span></p>
<p class=MsoPlainText><span style='font-size:12.0pt;font-family:"Times New Roman","serif"'>Journalism
Fellowships, from 1982 to 1998, when he became an STS <o:p></o:p></span></p>
<p class=MsoPlainText><span style='font-size:12.0pt;font-family:"Times New Roman","serif"'>Visiting
Scholar. Since then, he as published three books, Insisting <o:p></o:p></span></p>
<p class=MsoPlainText><span style='font-size:12.0pt;font-family:"Times New Roman","serif"'>on
the Impossible, The Life of Edwin Land, Inventor of Instant <o:p></o:p></span></p>
<p class=MsoPlainText><span style='font-size:12.0pt;font-family:"Times New Roman","serif"'>Photography
(Perseus, 1998); Watson and DNA: Making a Scientific <o:p></o:p></span></p>
<p class=MsoPlainText><span style='font-size:12.0pt;font-family:"Times New Roman","serif"'>Revolution
(Perseus 2003); and Drawing the Map of Life: Inside the <o:p></o:p></span></p>
<p class=MsoPlainText><span style='font-size:12.0pt;font-family:"Times New Roman","serif"'>Human
Genome Project (Basic Books, 2010). Earlier he was a staff <o:p></o:p></span></p>
<p class=MsoPlainText><span style='font-size:12.0pt;font-family:"Times New Roman","serif"'>reporter
for the Charlotte (NC) Observer, Science magazine, the Boston <o:p></o:p></span></p>
<p class=MsoPlainText><span style='font-size:12.0pt;font-family:"Times New Roman","serif"'>Globe,
and the New York Times, covering such topics as science in <o:p></o:p></span></p>
<p class=MsoPlainText><span style='font-size:12.0pt;font-family:"Times New Roman","serif"'>Antarctica,
the nuclear energy program of India, the Apollo lunar <o:p></o:p></span></p>
<p class=MsoPlainText><span style='font-size:12.0pt;font-family:"Times New Roman","serif"'>landing
program, and, starting in 1960, advances in biological <o:p></o:p></span></p>
<p class=MsoPlainText><span style='font-size:12.0pt;font-family:"Times New Roman","serif"'>science.
In 1978-82, he was the first director of the Banbury Center <o:p></o:p></span></p>
<p class=MsoPlainText><span style='font-size:12.0pt;font-family:"Times New Roman","serif"'>of
Cold Spring Harbor Laboratory.<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:12.0pt;font-family:"Times New Roman","serif"'><o:p> </o:p></span></p>
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