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<p class="MsoNormal"><span style="font-size:15.0pt">There will be a <b><span style="color:red">virtual</span></b><span style="color:red">
</span>Modern Optics and Spectroscopy Seminar held <b>tomorrow, May 24 at 12pm. </b>
A short Q&A segment will immediately follow the conclusion of the seminar.</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt"> </span><o:p></o:p></p>
<p class="MsoNormal"><b><span style="font-size:15.0pt">Zoom link:<i><span style="color:red">
<a href="https://mit.zoom.us/j/98625465964?pwd=SU0rZ0syc1JUL2RBenZRdE8weE5PQT09">
<span style="color:red">https://mit.zoom.us/j/98625465964?pwd=SU0rZ0syc1JUL2RBenZRdE8weE5PQT09</span></a></span><br>
</i>Password: <span style="color:red">224533</span><o:p></o:p></span></b></p>
<p class="MsoNormal"><b><span style="font-size:15.0pt">__________________________</span></b><o:p></o:p></p>
<p class="MsoNormal" style="margin-bottom:13.0pt"><b><span style="font-size:18.0pt"><br>
Gerwin Puppels<br>
</span></b><b><span style="font-size:17.0pt">RiverD International B.V.</span></b><i><span style="font-size:14.0pt"><br>
<br>
</span></i><b><i><span style="font-size:16.0pt">“</span></i></b><b><i><span lang="EN-GB" style="font-size:16.0pt;color:black">In vivo skin characterisation and skin penetration analysis by confocal Raman spectroscopy.</span></i></b><b><i><span style="font-size:16.0pt">”<br>
<br>
</span></i></b><i><span lang="EN-GB" style="font-size:13.0pt">The skin is the barrier between the body and the outside world. The total skin surface area of the adult body is about 2 m2. It prevents uncontrolled loss of water and keeps chemicals and microorganisms
out. However, until now the ability to actually measure and quantify how well this barrier works has eluded us. Current methods are indirect, have reproducibility issues, are invasive and/or use conditions that are far from actual in vivo conditions. They
leave a lot to wish for.</span></i><i><span style="font-size:13.0pt"><o:p></o:p></span></i></p>
<p class="MsoNormal"><i><span lang="EN-GB" style="font-size:13.0pt">This poses a problem for topical product development in personal care industry and pharmaceutical industry. The absence of a reliable method which non-invasively determines the penetration
and permeation of a topically applied product, also creates a hurdle for so-called bioequivalence studies, which are required to bring a generic pharmaceutical products to market.</span></i><i><span style="font-size:13.0pt"><o:p></o:p></span></i></p>
<p class="MsoNormal" style="margin-bottom:13.0pt"><i><span lang="EN-GB" style="font-size:13.0pt">Various (vibrational spectroscopic) techniques are being developed to address this problem.</span></i><i><span style="font-size:13.0pt"><o:p></o:p></span></i></p>
<p class="MsoNormal"><i><span lang="EN-GB" style="font-size:13.0pt">This presentation will discuss quantitative analysis of skin penetration of a topically applied material by in vivo confocal Raman spectroscopy, It will address methodological aspects and limits
of detection, as well as illustrate how it can be used to optimize product formulation, and how much the penetration rate of a product can differ between different parts of the body. </span></i><i><span style="font-size:13.0pt"><o:p></o:p></span></i></p>
<p class="MsoNormal"><i><br>
_____________________</i><i><span style="font-size:11.0pt"><br>
</span></i> <o:p></o:p></p>
<p class="MsoNormal"><b><span style="font-size:11.0pt">Christine Brooks</span></b><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt">Administrative Assistant</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt">Massachusetts Institute of Technology</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt">Department of Chemistry</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt">77 Massachusetts Ave, 6-333</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt">Cambridge, MA 02139</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt">p: 617.253.7239</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt">e: <a href="mailto:cbrooks@mit.edu">cbrooks@mit.edu</a></span><o:p></o:p></p>
<p class="MsoNormal"> <o:p></o:p></p>
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