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<p class="MsoNormal"><span style="font-size:15.0pt">There will be a <b><span style="color:red">virtual</span></b><span style="color:red">
</span>Modern Optics and Spectroscopy Seminar held <b>today at 12pm. </b>A short Q&A segment will immediately follow the conclusion of the seminar.</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt"> </span><o:p></o:p></p>
<p class="MsoNormal"><b><i><span style="font-size:15.0pt">Zoom link:<span style="color:red">
<a href="https://mit.zoom.us/j/94290878897?pwd=Z09LenVWMkUzbTVQeXdNWTRBeUV4dz09">
<span style="color:red">https://mit.zoom.us/j/94290878897?pwd=Z09LenVWMkUzbTVQeXdNWTRBeUV4dz09</span></a></span><br>
</span></i></b><b><span style="font-size:16.0pt">Password: <span style="color:red">
654362</span><o:p></o:p></span></b></p>
<p class="MsoNormal"><b><span style="font-size:15.0pt">__________________________</span></b><o:p></o:p></p>
<p class="MsoNormal"><b><span style="font-size:18.0pt"><br>
Giuliano Scarcelli<br>
</span></b><b><span style="font-size:17.0pt">University of Maryland</span></b><i><span style="font-size:14.0pt"><br>
<br>
</span></i><b><i><span style="font-size:16.0pt">“Brillouin microscopy for cell and tissue biomechanics”<o:p></o:p></span></i></b></p>
<p class="MsoNormal"><i><br>
The interaction between photons and acoustic phonons within materials, first described by Leon Brillouin, has been widely investigated to characterize mechanical and physical properties of samples. To translate this technology to biomedical applications where
mechanical properties are often critical, our lab has developed high-resolution spectrometers at high throughput and combined them with optical microscopes to yield 3D imaging modalities that use label-free biophysical properties as contrast mechanisms for
imaging. Our first area of application has been in ophthalmology as the loss of corneal strength leads to ectasia and is a major risk factor for refractive surgery complications. To address this issue, we have developed an in vivo Brillouin ophthalmoscope
and encouraging data show we can differentiate ectatic corneas as well as characterize outcome of emerging treatments. More recently we have demonstrated increased Brillouin microscopy resolution to characterize intracellular modulus and we developed a flow
cytometry platform to rapidly characterize cells based on their mechanical properties. Finally, we will discuss the physics behind the interpretation of Brillouin spectral signatures in the context of soft matter such as cells and tissues.<o:p></o:p></i></p>
<p class="MsoNormal"><i><br>
_____________________</i><i><span style="font-size:11.0pt"><br>
</span></i> <o:p></o:p></p>
<p class="MsoNormal"><b><span style="font-size:11.0pt">Christine Brooks</span></b><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt">Administrative Assistant</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt">Massachusetts Institute of Technology</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt">Department of Chemistry</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt">77 Massachusetts Ave, 6-333</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt">Cambridge, MA 02139</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt">p: 617.253.7239</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt">e: <a href="mailto:cbrooks@mit.edu">cbrooks@mit.edu</a></span><o:p></o:p></p>
<p class="MsoNormal"> <o:p></o:p></p>
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