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<p class="MsoNormal"><span style="font-size:15.0pt">There will be a <b><span style="color:red">virtual</span></b><span style="color:red">
</span>Modern Optics and Spectroscopy Seminar held <b>today at 12pm. </b>A Q&A segment will immediately follow the conclusion of the seminar.</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt"> </span><o:p></o:p></p>
<p class="MsoNormal"><b><i><span style="font-size:15.0pt">Zoom link:</span></i></b><o:p></o:p></p>
<p class="MsoNormal"><b><span style="font-size:16.0pt;color:red"><a href="https://mit.zoom.us/j/99877133683?pwd=SStVTW4vY25UUGFySXhwc3FuV3UzUT09"><span style="color:red">https://mit.zoom.us/j/99877133683?pwd=SStVTW4vY25UUGFySXhwc3FuV3UzUT09</span></a></span></b><o:p></o:p></p>
<p class="MsoNormal"><b><span style="font-size:16.0pt">Password: 794455</span></b><o:p></o:p></p>
<p class="MsoNormal"><b><span style="font-size:15.0pt">__________________________</span></b><o:p></o:p></p>
<p class="MsoNormal"><b><span style="font-size:18.0pt">Gilad Haran</span></b><b><span style="font-size:17.0pt"><br>
Weizmann Institute of Science (Israel)</span></b><i><span style="font-size:14.0pt"><br>
<br>
</span></i><b><i><span style="font-size:18.0pt">“<span style="color:black">Single-particle spectroscopy: from quantum plasmonics to microsecond protein dynamics</span>”</span></i></b><o:p></o:p></p>
<p class="MsoNormal"><br>
<i><span style="font-size:13.0pt;color:black">Single-particle spectroscopy has been a driving force for progress in chemical and biological physics in the last 20 years. In this lecture, I will describe two projects where methods development has led us into
new exciting realms of science at the level of the individual particle/molecule. I will first talk about our efforts to marry quantum optics with plasmonics and generate tiny optical cavities that can couple light to colloidal quantum dots in order to drive
strong-coupling phenomena at room temperature (1, 2). I will then switch gears and demonstrate how photon-by-photon single-molecule FRET probes large-scale protein dynamics. The motion of protein domains is essential for their function, and theory suggests
that it can occur on the microsecond time scale, several orders of magnitude faster than functional cycles. I will show that this is indeed the case with a couple of experimental examples and point to novel potential roles for fast dynamics (3).</span></i><o:p></o:p></p>
<p class="MsoNormal"><i><span style="font-size:13.0pt;color:black"> </span></i><o:p></o:p></p>
<p class="MsoNormal" style="margin-left:.5in;text-indent:-.5in"><i><span style="font-size:13.0pt;color:black">1. Santhosh K, Bitton O, Chuntonov L, & Haran G (2016) Vacuum Rabi splitting in a plasmonic cavity at the single quantum emitter limit. Nature
communications 7:ncomms11823.</span></i><o:p></o:p></p>
<p class="MsoNormal" style="margin-left:.5in;text-indent:-.5in"><i><span style="font-size:13.0pt;color:black">2. Bitton O, Gupta SN, Houben L, Kvapil M, Krapek V, Sikola T, & Haran G (2020) Vacuum Rabi splitting of a dark plasmonic cavity mode revealed
by fast electrons. Nature communications 11(1):487.</span></i><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:0in;margin-right:0in;margin-bottom:8.0pt;margin-left:.5in;text-indent:-.5in">
<i><span style="font-size:13.0pt;color:black">3. Haran G & Mazal H (2020) How fast are the motions of tertiary-structure elements in proteins? J Chem Phys153(13):130902.</span></i><o:p></o:p></p>
<p class="MsoNormal" style="text-align:justify"> <o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt"> </span><o:p></o:p></p>
<p class="MsoNormal"><b><span style="font-size:11.0pt">Christine Brooks</span></b><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt">Administrative Assistant</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt">Massachusetts Institute of Technology</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt">Department of Chemistry</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt">77 Massachusetts Ave, 6-333</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt">Cambridge, MA 02139</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt">p: 617.253.7239</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt">e: <a href="mailto:cbrooks@mit.edu">cbrooks@mit.edu</a></span><o:p></o:p></p>
<p class="MsoNormal"> <o:p></o:p></p>
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