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<p class="MsoNormal"><span style="font-size:15.0pt;color:black">There will be a Modern Optics and Spectroscopy Seminar held<span class="apple-converted-space"><b> </b></span><b>Tuesday, February 25th<span class="apple-converted-space"> </span></b>in<span class="apple-converted-space"> </span><b><a href="http://whereis.mit.edu/?go=34"><span style="color:#954F72">34-401A</span></a><span class="apple-converted-space"> </span>at
12pm</b></span><span style="color:black"><o:p></o:p></span></p>
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<b><span style="font-size:14.0pt;color:red"> </span></b><b><span style="font-size:14.0pt;color:black"> </span></b><span style="color:black"><o:p></o:p></span></p>
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<b><span style="font-size:20.0pt;color:black">Conor Evans<br>
</span></b><span class="3"><b><span style="font-size:16.0pt;color:black">Harvard University and Massachusetts General Hospital</span></b></span><i><span style="font-size:14.0pt;font-family:"Times New Roman",serif;color:black"><br>
<br>
</span></i><b><span style="font-size:18.0pt;font-family:"Arial",sans-serif;color:black">“Pharmacokinetic Tomography: Imaging and Quantifying Drug Uptake with Advanced Microscopy Tools”<br>
</span></b><span style="font-size:18.0pt;font-family:"Times New Roman",serif;color:red"><br>
</span><i><span style="font-size:12.0pt;color:black">Coherent Raman scattering (CRS) imaging tools provide a label-free means to visualize specific molecules within tissue, making CRS methods well suited for solving challenges in drug development. We will present
our efforts to leverage CRS tools to not only visualize the uptake of drugs within skin tissue, but also precisely quantify both pharmacokinetics and pharmacodynamics. We leverage deep learning methods, specifically the use of convoluted neural networks, for
accurate feature extraction to measure pharmacokinetics across numerous different skin compartments. Using single and multicomponent compartment models, we can analyze the CRS-derived data to calculate traditional PK parameters such as Tmax and Cmax on both
the micro- and macroscale. These approaches have been validated and now tested on multiple drugs in a range of formulations, demonstrating how CRS imaging tools can reveal new, previously-inaccessible PK and PD information. This research seeks to link the
microscale information gained via CRS microscopy to the macroscale measurements made in traditional PK/PD labs to understand drug flow, the impact of structure and formulation on diffusion, and how these parameters relate to drug efficacy.</span></i><b><span style="font-size:20.0pt;color:black"><o:p></o:p></span></b></p>
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<span style="font-size:14.0pt;color:black">Refreshments will be served immediately following the seminar!</span><span style="color:black"><o:p></o:p></span></p>
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<p class="MsoNormal"><i><span style="font-family:"Times New Roman",serif;color:black">Michelle Contos</span></i><span style="font-size:11.0pt;color:black"><o:p></o:p></span></p>
<p class="MsoNormal"><i><span style="font-family:"Times New Roman",serif;color:black">Administrative Assistant</span></i><span style="font-size:11.0pt;color:black"><o:p></o:p></span></p>
<p class="MsoNormal"><i><span style="font-family:"Times New Roman",serif;color:black">Massachusetts Institute of Technology</span></i><span style="font-size:11.0pt;color:black"><o:p></o:p></span></p>
<p class="MsoNormal"><i><span style="font-family:"Times New Roman",serif;color:black">Department of Chemistry</span></i><span style="font-size:11.0pt;color:black"><o:p></o:p></span></p>
<p class="MsoNormal"><i><span style="font-family:"Times New Roman",serif;color:black">77 Massachusetts Ave, 6-333</span></i><span style="font-size:11.0pt;color:black"><o:p></o:p></span></p>
<p class="MsoNormal"><i><span style="font-family:"Times New Roman",serif;color:black">Cambridge, MA 02139</span></i></p>
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