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<p class="MsoNormal"><span style="font-size:15.0pt;color:black">There will be a Modern Optics and Spectroscopy Seminar held<b>
</b></span><b><span style="font-size:15.0pt">tomorrow<span style="color:black">, November 19<span class="apple-converted-space"> </span></span></span></b><span style="font-size:15.0pt;color:black">in<span class="apple-converted-space"> </span><b><a href="http://whereis.mit.edu/?go=34"><span style="color:#954F72">34-401A</span></a><span class="apple-converted-space"> </span>at
12pm</b></span><o:p></o:p></p>
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<b><span style="font-size:14.0pt;color:red"> </span></b><b><span style="font-size:14.0pt;color:black"> </span></b><o:p></o:p></p>
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<span style="font-size:20.0pt;line-height:120%;font-family:"Calibri",sans-serif">Marcus Cicerone
</span><o:p></o:p></p>
<p class="a"><span class="3"><span style="font-size:16.0pt;line-height:120%;font-family:"Calibri",sans-serif;font-style:normal">Georgia Institute of Technology</span></span><i><span style="font-size:14.0pt;line-height:120%"><br>
<br>
</span></i><b><span style="font-size:18.0pt;line-height:120%;font-family:"Arial",sans-serif">“</span></b><span class="1"><span style="font-size:15.0pt;line-height:120%">Discovering Biology with Broadband Coherent Raman Microscopy”</span></span><o:p></o:p></p>
<p class="a"><span style="font-size:18.0pt;line-height:120%"><br>
</span><span class="4">Spectroscopic coherent Raman imaging (CRI) methods allow label-free, chemically specific imaging of materials and biological systems, and are opening up many exciting possibilities for understanding phenomena in these systems. When we
first introduced spectroscopic coherent Raman imaging in 2004, we could acquire spectra only from bulk polymers and liquids. Now, after many years of development, we easily acquire label-free micrographs of biological cells and tissues at 3.5 ms for each spectral
image pixel. Figure 1 provides an example of a murine pancreas section, showing major structural features, although much more spectral image information is available. Initially it was not clear that acquiring such spectra would be possible, but a recognition
that an intrinsic and strong nonresonant signal could be used to enhance weak resonant signals made it possible to obtain these signals above detector noise. Further improvements in signal generation and spectral retrieval algorithms, now provide for highly
robust and rapid spectral imaging. I will briefly introduce broadband spectroscopic coherent anti-Stokes Raman scattering (BCARS) microscopy, discussing some of the key concepts that make this method practical. I will also present selected application examples
from studies on <i>C. elegans</i> metabolism and human cytomegalovirus infection that highlight the utility of BCARS for discovering new biology through in-depth characterization of highly complex biological systems.</span><o:p></o:p></p>
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<span style="font-size:14.0pt;color:black">Refreshments will be served immediately following the seminar!</span><o:p></o:p></p>
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<i><span style="font-family:"Times New Roman",serif;color:black">Michelle Contos</span></i><o:p></o:p></p>
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<i><span style="font-family:"Times New Roman",serif;color:black">Administrative Assistant</span></i><o:p></o:p></p>
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<i><span style="font-family:"Times New Roman",serif;color:black">Massachusetts Institute of Technology</span></i><o:p></o:p></p>
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<i><span style="font-family:"Times New Roman",serif;color:black">Department of Chemistry</span></i><o:p></o:p></p>
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<i><span style="font-family:"Times New Roman",serif;color:black">77 Massachusetts Ave, 6-333</span></i><o:p></o:p></p>
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<i><span style="font-family:"Times New Roman",serif;color:black">Cambridge, MA 02139</span></i><o:p></o:p></p>
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