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<p class="MsoNormal"><span style="font-size:15.0pt;color:black">There will be a Modern Optics and Spectroscopy Seminar held<b> next Tuesday, November 19<span class="apple-converted-space"> </span></b>in<span class="apple-converted-space"> </span><b><a href="http://whereis.mit.edu/?go=34"><span style="color:#954F72">34-401A</span></a><span class="apple-converted-space"> </span>at
12pm</b></span><span style="color:black"><o:p></o:p></span></p>
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<b><span style="font-size:14.0pt;color:red"> </span></b><b><span style="font-size:14.0pt;color:black"> </span></b><span style="color:black"><o:p></o:p></span></p>
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<span lang="KO" style="font-size:20.0pt;line-height:120%;font-family:"Calibri",sans-serif">Marcus Cicerone</span><span lang="KO" style="font-size:20.0pt;line-height:120%;font-family:"Calibri",sans-serif">
</span><span style="font-size:20.0pt;line-height:120%;font-family:"Calibri",sans-serif"><o:p></o:p></span></p>
<p class="a"><span class="3"><span style="font-size:16.0pt;line-height:120%;font-family:"Calibri",sans-serif;font-style:normal">Georgia Institute of Technology</span></span><i><span lang="KO" style="font-size:14.0pt;line-height:120%"><br>
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</span></i><b><span lang="KO" style="font-size:18.0pt;line-height:120%;font-family:"Arial",sans-serif">“</span></b><span class="1"><span style="font-size:15.0pt;line-height:120%">Discovering Biology with Broadband Coherent Raman Microscopy”</span></span><i><span style="font-size:10.0pt;line-height:120%;font-family:"Times New Roman",serif"><o:p></o:p></span></i></p>
<p class="a"><span lang="KO" style="font-size:18.0pt;line-height:120%"><br>
</span><span class="4"><span style="line-height:120%">Spectroscopic coherent Raman imaging (CRI) methods allow label-free, chemically specific imaging of materials and biological systems, and are opening up many exciting possibilities for understanding phenomena
in these systems. When we first introduced spectroscopic coherent Raman imaging in 2004, we could acquire spectra only from bulk polymers and liquids. Now, after many years of development, we easily acquire label-free micrographs of biological cells and tissues
at 3.5 ms for each spectral image pixel. Figure 1 provides an example of a murine pancreas section, showing major structural features, although much more spectral image information is available. Initially it was not clear that acquiring such spectra would
be possible, but a recognition that an intrinsic and strong nonresonant signal could be used to enhance weak resonant signals made it possible to obtain these signals above detector noise. Further improvements in signal generation and spectral retrieval algorithms,
now provide for highly robust and rapid spectral imaging. I will briefly introduce broadband spectroscopic coherent anti-Stokes Raman scattering (BCARS) microscopy, discussing some of the key concepts that make this method practical. I will also present selected
application examples from studies on <i>C. elegans</i> metabolism and human cytomegalovirus infection that highlight the utility of BCARS for discovering new biology through in-depth characterization of highly complex biological systems.</span></span><i><span style="font-family:"Times New Roman",serif"><o:p></o:p></span></i></p>
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<span style="font-size:14.0pt;color:black">Refreshments will be served immediately following the seminar!</span><span style="color:black"><o:p></o:p></span></p>
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<i><span style="font-family:"Times New Roman",serif;color:black">Michelle Contos</span></i><span style="color:black"><o:p></o:p></span></p>
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<i><span style="font-family:"Times New Roman",serif;color:black">Administrative Assistant</span></i><span style="color:black"><o:p></o:p></span></p>
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<i><span style="font-family:"Times New Roman",serif;color:black">Massachusetts Institute of Technology</span></i><span style="color:black"><o:p></o:p></span></p>
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<i><span style="font-family:"Times New Roman",serif;color:black">Department of Chemistry</span></i><span style="color:black"><o:p></o:p></span></p>
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<i><span style="font-family:"Times New Roman",serif;color:black">77 Massachusetts Ave, 6-333</span></i><span style="color:black"><o:p></o:p></span></p>
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<i><span style="font-family:"Times New Roman",serif;color:black">Cambridge, MA 02139</span></i><span style="color:black"><o:p></o:p></span></p>
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