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<p class="MsoNormal"><span style="font-size:14.0pt">There will be a Modern Optics and Spectroscopy Seminar held
<b>tomorrow, February 12 at 12pm </b>in <b><span style="color:red">1-190</span></b></span><o:p></o:p></p>
<p class="MsoNormal"><b><span style="font-size:14.0pt;color:red"> </span></b><o:p></o:p></p>
<p class="MsoNormal"><b><span style="font-size:14.0pt;color:red">**Please note location**</span></b><o:p></o:p></p>
<p class="MsoNormal"><b><span style="font-size:14.0pt"> </span></b><o:p></o:p></p>
<p class="MsoNormal" style="layout-grid-mode:char;vertical-align:baseline"><b><span style="font-size:16.0pt">YongKeun (Paul) Park<br>
KAIST, Korea</span></b><i><span style="font-size:14.0pt"><br>
<br>
</span></i><b><i><span style="font-size:16.0pt">“Holotomography and artificial intelligence:
<br>
from label-free live cells imaging to medical applications exploiting cell phenotypes”</span></i></b><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:10.0pt"> </span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:10.0pt"> </span><o:p></o:p></p>
<p class="MsoNormal" style="layout-grid-mode:char;vertical-align:baseline"><i><span style="color:black">Holotomography (HT) is a 3D quantitative phase imaging technique, which uses laser interferometry to provide the 3-D label-free imaging of live cells and
tissues. As an optical analogous to X-ray computed tomography (CT), HT measures multiple 2-D holograms of a sample with various illumination angles, from which the 3-D refractive index (RI) distribution of the sample is reconstructed by inversely solving the
wave equation. Unlike conventional fluorescence-based microscopy, HT provides label-free imaging capability. Without any fixation or labeling, 3-D images of live cells can be obtained with high spatial resolution (down to 110 nm). Furthermore, HT provides
quantitative imaging capability: RI maps of a cell are precisely and quantitative measured, from which various cellular analysis can be followed.
</span></i><o:p></o:p></p>
<p class="MsoNormal" style="layout-grid-mode:char;vertical-align:baseline"><i><span style="color:black"> In this seminar, we will present the principles of HT and applications. In particular, we will discuss the potentials of HT in medical applications, including
the study of CAR-T cells interacting with target cancer cells and rapid label-free identification of cells using 3D phenotypes.
</span></i><o:p></o:p></p>
<p class="MsoNormal" style="layout-grid-mode:char;vertical-align:baseline"><i><span style="color:black"> </span></i><o:p></o:p></p>
<p class="MsoNormal" style="layout-grid-mode:char;vertical-align:baseline"><b><i><u><span style="color:black">References
</span></u></i></b><o:p></o:p></p>
<p class="MsoNormal" style="layout-grid-mode:char;vertical-align:baseline"><i><span style="color:black">1. YK Park et al., Quantitative phase imaging in biomedicine, Nature Photonics, 12, 578–589 (2018)</span></i><o:p></o:p></p>
<p class="MsoNormal" style="layout-grid-mode:char;vertical-align:baseline"><i><span style="color:black">2. Y Jo et al., Quantitative Phase Imaging and Artificial Intelligence: A Review, IEEE Journal of Selected Topics in Quantum Electronics, 25(1), 6800914
(2019)</span></i><o:p></o:p></p>
<p class="MsoNormal"> <br>
<br>
<o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:14.0pt">Refreshments will be served immediately following the seminar!</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt"> </span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt"> </span><o:p></o:p></p>
<p class="MsoNormal"><b><span style="font-size:11.0pt">Christine Brooks</span></b><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt">Administrative Assistant</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt">Massachusetts Institute of Technology</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt">Department of Chemistry</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt">77 Massachusetts Ave, 6-333</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt">Cambridge, MA 02139</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt">p: 617.253.7239</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt">e: <a href="mailto:cbrooks@mit.edu">cbrooks@mit.edu</a></span><o:p></o:p></p>
<p class="MsoNormal"> <o:p></o:p></p>
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