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<p class="MsoNormal"><span style="font-size:14.0pt">There will be a Modern Optics and Spectroscopy Seminar held
<b>today, April 17 at 12pm </b>in <b>34-401</b></span> <o:p></o:p></p>
<p class="MsoNormal"><b><span style="font-size:14.0pt"> </span></b><o:p></o:p></p>
<p class="MsoNormal"><b><span style="font-size:14.0pt">Professor Ishan Barman</span></b><o:p></o:p></p>
<p class="MsoNormal"><i><span style="font-size:14.0pt">Department of Mechanical Engineering & Department of Oncology<br>
Johns Hopkins University</span></i><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:14.0pt"> </span><o:p></o:p></p>
<p class="MsoNormal"><b><i><span style="font-size:14.0pt">“Decoding the molecular pathology of cancer with vibrational spectroscopy”
</span></i></b><o:p></o:p></p>
<p class="MsoNormal"><b><i><span style="font-size:14.0pt"> </span></i></b><o:p></o:p></p>
<p class="MsoNormal"><i><span style="font-size:14.0pt">Understanding the metastatic progression of cancer remains challenging due in part to a rudimentary knowledge of metabolic, physiologic, and molecular adaptations that allow for the cancer to survive and
thrive within different tissue types. Raman spectroscopy is particularly attractive for the analysis of cancer cells and their microenvironment as it permits a rapid and simultaneous fingerprinting of inherent biologic content, extraneous materials and functional
state without the use of labeled probes. Leveraging such non-perturbative analysis, we have generated novel molecular descriptions of the poorly understood pre-metastatic niche, i.e. the collective changes at the distant metastatic sites prior to the arrival
of the tumor cells. Additionally, we have determined clinically relevant spectral markers of early metastatic disease in bone that permit detection significantly before morphologic variations are captured through radiographic diagnosis. A second module of
our research focuses on engineering nanostructured plasmonic probes for ultrasensitive detection of specific molecular species. The high sensitivity and broad applicability of these plasmonic nanoprobes, in conjunction with their inert composition, render
them a promising agent for serum profiling as well as for precise delineation of microscopic tumors that are impossible to visualize with currently available imaging technologies.</span></i><span style="font-size:11.0pt"><br>
<br>
<br>
</span><o:p></o:p></p>
<p class="MsoNormal">Refreshments will be served immediately following the seminar<o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt"> </span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt"> </span><o:p></o:p></p>
<p class="MsoNormal"><b><span style="font-size:11.0pt">Christine Brooks</span></b><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt">Administrative Assistant</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt">Massachusetts Institute of Technology</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt">Department of Chemistry</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt">77 Massachusetts Ave, 6-333</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt">Cambridge, MA 02139</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt">p: 617.253.7239</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt">e: <a href="mailto:cbrooks@mit.edu">cbrooks@mit.edu</a></span><o:p></o:p></p>
<p class="MsoNormal"> <o:p></o:p></p>
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