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<p class="MsoNormal"><o:p>&nbsp;</o:p></p>
<p class="MsoNormal"><span style="color:#0070C0">&nbsp;</span><o:p></o:p></p>
<p class="MsoNormal"><b><span style="font-size:18.0pt;color:#0070C0">*****SAVE THE DATE******MAY 1<sup>st</sup>******in 14 DAYS!!*******</span></b><o:p></o:p></p>
<p class="MsoNormal">&nbsp;<o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:3.5pt;margin-right:66.3pt;margin-bottom:0in;margin-left:0in;margin-bottom:.0001pt;text-indent:.5in">
<b><u><span style="font-size:28.0pt;font-family:&quot;Times New Roman&quot;,serif;color:#17375E">Lester Wolfe Workshop in Laser Biomedicine</span></u></b><o:p></o:p></p>
<p class="MsoBodyText" style="margin-top:.5pt"><b><span style="font-size:17.5pt">&nbsp;</span></b><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:0in;margin-right:66.3pt;margin-bottom:0in;margin-left:.5in;margin-bottom:.0001pt;text-indent:.5in">
<b><span style="font-size:26.0pt;font-family:&quot;Times New Roman&quot;,serif">“<i>Photons in the Fight Against Cancer:
</i></span></b><o:p></o:p></p>
<p class="MsoNormal" style="margin-right:66.3pt"><b><i><span style="font-size:12.0pt">&nbsp;</span></i></b><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:0in;margin-right:66.3pt;margin-bottom:0in;margin-left:.5in;margin-bottom:.0001pt;text-indent:.5in">
<b><i><span style="font-size:26.0pt;font-family:&quot;Times New Roman&quot;,serif">Optics in Immuno-oncology”</span></i></b><o:p></o:p></p>
<p class="MsoBodyText" style="margin-top:.4pt"><b>&nbsp;</b><o:p></o:p></p>
<p class="MsoBodyText" style="mso-margin-top-alt:11.9pt;margin-right:44.25pt;margin-bottom:0in;margin-left:26.05pt;margin-bottom:.0001pt">
<img width="723" height="4" id="_x0000_i1025" src="cid:image001.png@01D3D659.A678BBC0"><span style="font-size:14.0pt">After decades of disappointment, immunotherapy for cancer is now considered the brightest hope for conquering the dread disease. Checkpoint
 inhibitors, CAR-T cells, and antibody targeted therapeutics are leading the way. This Lester-Wolfe Workshop examines the role that optics and photonics are playing in this endeavor. In vivo optical imaging and optical theranostics are some of the topics that
 will be addressed.</span><o:p></o:p></p>
<h1 style="margin-left:27.55pt"><br>
Measuring and Modeling Therapeutic Mechanism in Single Cells<o:p></o:p></h1>
<p class="MsoBodyText" style="mso-margin-top-alt:.65pt;margin-right:53.5pt;margin-bottom:0in;margin-left:27.55pt;margin-bottom:.0001pt">
Peter Sorger, Ph.D, Otto Krayer Professor of Systems Pharmacology Department of Systems&nbsp; Biology,&nbsp; Harvard&nbsp; Medical School<o:p></o:p></p>
<h1 style="margin-top:9.45pt">Optotheranostics<o:p></o:p></h1>
<p class="MsoBodyText" style="mso-margin-top-alt:0in;margin-right:49.5pt;margin-bottom:0in;margin-left:23.95pt;margin-bottom:.0001pt">
Shawn Chen (Xiaoyuan Chen, Ph.D.), Senior Investigator, Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering<o:p></o:p></p>
<h1 style="margin-top:6.9pt">Real-Time PK/PD Imaging of Immunotherapy – RPPI<o:p></o:p></h1>
<p class="MsoBodyText" style="margin-top:.2pt;text-indent:23.95pt">Mikael Pittet, MD, Associate Professor, Radiology, Harvard Medical School<o:p></o:p></p>
<h1 style="margin-top:9.45pt">Exploring the Connection Between Innate Immunity and Hemodynamics during Cancer Treatments Using Diffuse and Nonlinear Optical Imaging
<br>
<span style="font-size:12.0pt;font-weight:normal">Darren Roblyer, Ph.D, Assistant Professor, Biomedical Engineering, BU College of Engineering</span><o:p></o:p></h1>
<h1 style="margin-top:9.45pt">&nbsp;<o:p></o:p></h1>
<p class="MsoBodyText" style="margin-top:.15pt"><img width="721" height="3" id="_x0000_i1026" src="cid:image002.png@01D3D659.A678BBC0"><o:p></o:p></p>
<h2 align="left" style="margin-left:.5in;text-align:left;text-indent:26.1pt;line-height:15.8pt;mso-line-height-rule:exactly">
<b><span style="font-size:18.0pt;color:#17375E">Tuesday, May 1<sup>st</sup>, 2018, 3:30-6:00 PM</span></b><o:p></o:p></h2>
<p class="MsoNormal" style="mso-margin-top-alt:0in;margin-right:173.5pt;margin-bottom:0in;margin-left:26.1pt;margin-bottom:.0001pt;text-indent:.5in;line-height:105%">
<span style="font-size:14.0pt;line-height:105%;font-family:&quot;Times New Roman&quot;,serif">Massachusetts General Hospital
</span><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:0in;margin-right:173.5pt;margin-bottom:0in;margin-left:26.1pt;margin-bottom:.0001pt;text-indent:.5in;line-height:105%">
<span style="font-size:14.0pt;line-height:105%;font-family:&quot;Times New Roman&quot;,serif">Simches Research Building</span><o:p></o:p></p>
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<span style="font-size:14.0pt;font-family:&quot;Times New Roman&quot;,serif">3</span><span style="font-size:9.0pt;font-family:&quot;Times New Roman&quot;,serif;position:relative;top:-6.5pt;mso-text-raise:6.5pt">rd
</span><span style="font-size:14.0pt;font-family:&quot;Times New Roman&quot;,serif">Floor, Room 3110</span><o:p></o:p></p>
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<span style="font-size:14.0pt;font-family:&quot;Times New Roman&quot;,serif">185 Cambridge Street, Boston, MA</span><o:p></o:p></p>
<p class="MsoBodyText" style="margin-top:.45pt"><span style="font-size:13.5pt">&nbsp;</span><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:0in;margin-right:66.3pt;margin-bottom:0in;margin-left:62.2pt;margin-bottom:.0001pt">
<i><span style="font-size:14.0pt;font-family:&quot;Times New Roman&quot;,serif;color:#17375E">Refreshments served at 3:00 PM, Room 3110</span></i><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:.65pt;margin-right:66.3pt;margin-bottom:0in;margin-left:62.15pt;margin-bottom:.0001pt">
<span style="font-size:14.0pt;font-family:&quot;Times New Roman&quot;,serif">No R.S.V.P. required</span><o:p></o:p></p>
<p class="MsoBodyText"><span style="font-size:14.0pt">&nbsp;</span><o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:0in;margin-right:66.3pt;margin-bottom:0in;margin-left:62.15pt;margin-bottom:.0001pt">
<i><span style="font-family:&quot;Times New Roman&quot;,serif">Sponsored by the MIT Laser Biomedical Research Center, MIT, MGH Wellman Center for Photomedicine, and the Harvard-MIT Division of Health Sciences and Technology</span></i><o:p></o:p></p>
<p class="MsoNormal">&nbsp;<o:p></o:p></p>
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