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<p class="MsoNormal"><span style="font-size:14.0pt">There will be a Modern Optics and Spectroscopy Seminar held next
<b>Tuesday, April 3 at 12pm </b>in <b>34-401</b></span><o:p></o:p></p>
<p class="MsoNormal"><b><span style="font-size:14.0pt"> </span></b><o:p></o:p></p>
<p class="MsoNormal"><b><span style="font-size:14.0pt">Ming Guo</span></b><o:p></o:p></p>
<p class="MsoNormal"><i><span style="font-size:14.0pt">Massachusetts Institute of Technology</span></i><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:14.0pt"> </span><o:p></o:p></p>
<p class="MsoNormal"><b><i><span style="font-size:14.0pt">“Biomechanical Imaging of Cell-Matrix Interaction in 3D<o:p></o:p></span></i></b></p>
<p class="MsoNormal"><b><i><span style="font-size:14.0pt"><o:p> </o:p></span></i></b></p>
<p class="MsoNormal"><i><span style="font-size:14.0pt">Living cells typically grow in a three dimensional (3D) environments. The physical properties of the matrix are known to significantly impact cell behavior, such as cell stiffness, morphology, migration,
and stem-cell differentiation. However, cells also constantly reorganize the structure of their surrounding matrix during physiological processes; this is thought to also change the physical properties of the surrounding matrix, which may then have immediate
impacts on cell behavior. In this talk, I will present our recent progress on experimentally characterizing the local changes in the matrix structure and mechanics induced by individual living cells inside a 3D biopolymer matrix, through direct microscopy
and micromechanical measurement. Moreover, I will introduce a method, called Nonlinear Stress Inference Microscopy, with which we can determine the cell-induced local matrix stress from nonlinear microrheology measurements inside various types of extracellular
matrix in 3D, without requiring detailed knowledge of the material constitutive relation of these respective systems. In addition, I will also introduce our recent progress on characterizing the significant role of vimentin intermediate filament in determining
nonlinear mechanics of mammalian cytoskeleton.<o:p></o:p></span></i></p>
<p class="MsoNormal"><span style="font-size:11.0pt"><br>
<br>
</span><o:p></o:p></p>
<p class="MsoNormal">Refreshments will be served immediately following the seminar<o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt"> </span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt"> </span><o:p></o:p></p>
<p class="MsoNormal"><b><span style="font-size:11.0pt">Christine Brooks</span></b><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt">Administrative Assistant</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt">Massachusetts Institute of Technology</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt">Department of Chemistry</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt">77 Massachusetts Ave, 6-333</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt">Cambridge, MA 02139</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt">p: 617.253.7239</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt">e: <a href="mailto:cbrooks@mit.edu">cbrooks@mit.edu</a></span><o:p></o:p></p>
<p class="MsoNormal"> <o:p></o:p></p>
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