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<p class="MsoNormal"><span style="font-size:14.0pt">There will be a Modern Optics and Spectroscopy Seminar held today,<b> December 5 at 12pm
</b>in 34-401:</span><o:p></o:p></p>
<p class="MsoNormal"><b><span style="font-size:14.0pt"> </span></b><o:p></o:p></p>
<p class="MsoNormal"><b><span style="font-size:14.0pt">Rizal F. Hariadi</span></b><o:p></o:p></p>
<p class="MsoNormal"><i><span style="font-size:14.0pt">Department of Physics, Biodesign Institute</span></i><o:p></o:p></p>
<p class="MsoNormal"><i><span style="font-size:14.0pt">Arizona State University</span></i><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:14.0pt"> </span><o:p></o:p></p>
<p class="MsoNormal"><b><i><span style="font-size:16.0pt">Protein and DNA origami nanoarrays: from dissecting molecular machines to democratizing digital diagnostics</span></i></b><o:p></o:p></p>
<p class="MsoNormal"><b><i><span style="font-size:14.0pt"> </span></i></b><o:p></o:p></p>
<p class="MsoNormal"><i><span style="font-size:14.0pt">Abstract – The functions of complex biological systems arise, in part, from the organization and subtle interactions of biomolecules. DNA origami, in combination with conjugation strategies, offers a unique
opportunity to organize biomolecules for applications in biophysics and diagnostics. In this talk, I will present our latest research demonstrating the exquisite positional control of DNA origami technology across multiple length scales. In the first part
of my talk, I will show two DNA-nanostructure-guided protein arrays for dissecting collective behaviors of molecular machines consisting of 100-nm-sized rectangular DNA origami nanostructures and tens-of-micron-long DNA nanotubes, patterned with myosin motors.
These studies uncover elegant engineering principles for designing force sensors and molecular transporters on complex landscapes. In the second half of the talk, I will present some recent results obtained in collaboration with Ashwin Gopinath and Paul Rothemund
on the development of lithography-free cm-scale DNA origami nanoarrays. Finally, I will conclude with a discussion on the transformative potential and future directions of protein and DNA nanoarrays, including high-throughput single-molecule biophysics and
low-cost digital diagnostics that target minuscule concentrations of DNA.</span></i><span style="font-size:11.0pt"><br>
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<p class="MsoNormal">Refreshments will be served immediately following the seminar<o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt"> </span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt"> </span><o:p></o:p></p>
<p class="MsoNormal"><b><span style="font-size:11.0pt">Christine Brooks</span></b><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt">Administrative Assistant</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt">Massachusetts Institute of Technology</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt">Department of Chemistry</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt">77 Massachusetts Ave, 6-333</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt">Cambridge, MA 02139</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt">p: 617.253.7239</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt">e: <a href="mailto:cbrooks@mit.edu">cbrooks@mit.edu</a></span><o:p></o:p></p>
<p class="MsoNormal"> <o:p></o:p></p>
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