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<b><span style="font-size: 18pt;">Seminar on<o:p></o:p></span></b></p>
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<b><span style="font-size: 8pt; font-family: 'Times New Roman';"> </span></b></p>
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<b><span style="font-size: 24pt; letter-spacing: 1.5pt;">Modern Optics and Spectroscopy</span></b><span style="font-size: 24pt; font-family: Arial; letter-spacing: 1.5pt;"><o:p></o:p></span></p>
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<b><span style="font-size: 16pt; font-family: Arial; letter-spacing: 1pt;"> <o:p></o:p></span></b></p>
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<b><i><span style="font-size: 20pt; letter-spacing: 1pt;">At the nano-bio interface: Probing live cells with nano sensors<o:p></o:p></span></i></b></p>
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<b><i><span style="font-size: 16pt; letter-spacing: 1pt;"> </span></i></b></p>
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<b> </b></p>
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<b><span style="font-size: 24pt;">Bianxiao Cui<o:p></o:p></span></b></p>
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<b><span style="font-size: 8pt;"> </span></b></p>
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<span style="font-size: 18pt; font-family: 'Times New Roman'; font-weight: normal; font-style: normal;">Stanford University<o:p></o:p></span></p>
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<span style="font-size: 16pt; letter-spacing: 1pt;"> </span></p>
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<span style="font-size: 22pt; letter-spacing: 1pt;">Tuesday, April 12, 2016<o:p></o:p></span></p>
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<span style="font-size: 22pt; letter-spacing: 1pt;">12:00 – 1:00 p.m.<o:p></o:p></span></p>
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<span style="letter-spacing: 1pt;"> </span></p>
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The rapidly evolving field of nanotechnology creates new frontiers for biological sciences. Recently, we and other groups show that vertical nanopillars protruding from a flat surface support cell survival and can be used as subcellular sensors to probe biological
processes in live cells. In particular, we are exploring nanopillars for sensing cellular electric signal, mechanical signal, and membrane curvature. As an electrode sensor, nano-electrodes offer several advantages such as high sensitivity, subcellular spatial
resolution, and precise control of the sensor geometry. We found that the 3D topology of the nanopillars electrodes is crucial for its enhanced signal detection. The high membrane curvature induced by vertical nanopillars significantly affects the distribution
of curvature-sensitive proteins and stimulates several cellular processes in live cells. Interestingly, vertical nanopillars also induce well-controlled nuclear deformation. We use it as a unique platform to study nuclear rigidity and nuclear mechanotransduction
in gene expression. Overall, our studies show a strong interplay between biological cells and nano-sized sensors, which is an essential consideration for future development of interfacing devices.<o:p></o:p></p>
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<span style="font-size: 16pt;">Grier Room, MIT Bldg. 34-401<o:p></o:p></span></p>
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<span style="font-size: 16pt;">Refreshments served after the lecture</span></p>
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