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<p class="MsoNormal" align="center" style="text-align:center"><span style="letter-spacing: 1pt; "><font size="4" face="Times New Roman">Massachusetts Institute of Technology</font></span></p>
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<p class="MsoNormal" style="text-align:justify;mso-line-height-alt:12.0pt"><font size="4" face="Times New Roman">One of the most exciting developments in molecular biology in the last decade has been the ability to look at singlebiomolecules and bring to light
the intricate mechanisms by which they carry out their function in the cell. Specifically, stochastic behaviours and heterogeneities which previously remained buried in ensemble averaging, have now become evident with single-molecule techniques, and believed
to be inherent to the mechanisms of regulating protein complex formation in vivo. In high order organisms, like humans, many important enzymes rely on high copy numbers and local crowding to facilitate and regulate their functions. These enzymes, pertaining
to a class of so called ‘weak and transient’ interactions, typically present too significant a background noise for direct visualization, and require unconventional single-molecule approaches. In this seminar, I will discuss our recent efforts in capturing
cooperative behaviours that emerge in live mammalian cells during transcription, the first step in the central dogma of molecular biology when genetic information in DNA is copied into a messenger RNA.</font></p>
<p class="MsoNormal" align="center"><font size="4" face="Times New Roman">Grier Room, MIT Bldg 34-401<o:p></o:p></font></p>
<p class="MsoNormal" align="center"><font size="4" face="Times New Roman">Refreshments served after the lecture</font><font size="6"><o:p></o:p></font></p>
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