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<!--StartFragment--><p class="MsoTitle" style="text-align: center;margin-right: -0.5in; "><b>Seminar on<o:p></o:p></b></p><p class="MsoTitle" style="text-align: center;margin-right: -0.5in; "><b> </b><b><span style="letter-spacing: 1.5pt; ">Modern Optics and Spectroscopy</span></b><b><span style="letter-spacing: 1pt; "> </span></b></p><p class="MsoNormal" align="center" style="text-align: center; "><b><i><span style="letter-spacing: 1pt; ">In Vivo Spectroscopic
Imaging: Analysis of Molecules in their
natural environment</span></i></b><b><i><span style="letter-spacing: 1pt; "> </span></i></b></p><p class="MsoNormal" align="center" style="text-align: center; "><b><span style="letter-spacing: 1pt; ">Ji-Xin Cheng,<o:p></o:p></span></b></p><p class="MsoNormal" align="center" style="text-align: center; "><span style="letter-spacing: 1pt; ">Purdue
University</span> </p>
<div style="text-align: center;">Tuesday, February 25, 2014</div></div><div style="word-wrap: break-word; -webkit-nbsp-mode: space; -webkit-line-break: after-white-space; "><div style="text-align: center;">12:00-1:00p.m.</div><p style="text-align: center;">Label-free
spectroscopic imaging using intrinsic molecular signals is opening a new window
for watching biomolecules and nanomaterials in live cells and even inside the
human body. Major advances have been made to allow real time vibrational
imaging of cellular processes, extraction of information from the crowded
fingerprint bands of a biological system, and chemical imaging of a tissue that
is a few centimeters deep under the surface. I will present our most recent
advances in both development and applications of spectroscopic imaging
platforms, including deep tissue imaging by acoustic detection of harmonic
molecular vibration [1], study of altered cholesterol metabolism in cancer by
Raman scattering microscopy [2], and super-resolution imaging of nanomaterials
by transient absorption microscopy [3].</p><p style="text-align: justify; ">[1] Han-Wei Wang Ning Chai, Pu Wang, Song Hu, Wei
Dou, David Umulis, Lihong V. Wang, Michael Sturek, Robert Lucht, Ji-Xin Cheng*,
“Label-free bond-selective imaging by listening to vibrationally excited
molecules”, <i><u>Phys. Rev. Lett.</u></i>,
2011, 106: 238106. [2] Shuhua Yue, Junjie Li, Seung-Young Lee, Hyeon Jeong Lee,
Tian Shao, Bing Song, Liang Cheng, Timothy A. Masterson, Xiaoqi Liu, Timothy L.
Ratliff, Ji-Xin Cheng*, “Cholesteryl
Ester Accumulation Induced by PTEN Loss and PI3K/AKT Activation Underlies Human
Prostate Cancer Aggressiveness”, <u>Cell Metabolism</u>, 2014, in press. [3] Pu Wang, Mikhail N. Slipchenko,
James Mitchell, Chen Yang, Eric O. Potma, Xianfan Xu, Ji-Xin Cheng*, “Far-field
imaging of non-fluorescent species with sub-diffraction resolution”, <u>Nature
Photonics</u>, 2013, 7(6): 449-453.</p><div><br></div><p class="MsoNormal" align="center" style="text-align: center; ">Grier Room, MIT Bldg 34-401<o:p></o:p></p><p class="MsoNormal" align="center" style="text-align: center; ">Refreshments served after
the lecture<o:p></o:p></p>
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