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<!--StartFragment--><div style="margin-top: 0in; margin-right: -0.5in; margin-left: 2in; margin-bottom: 0.0001pt; text-align: left; text-indent: 0.5in; "><b style="mso-bidi-font-weight:normal"><span style="font-family:"Times New Roman""><font class="Apple-style-span" size="4"><span class="Apple-tab-span" style="white-space:pre"> </span>Seminar on<o:p></o:p></font></span></b></div><p class="MsoTitle" style="margin-right:-.5in"><font class="Apple-style-span" face="'Times New Roman'" size="4"><b><br></b></font></p><p class="MsoNormal" align="center" style="text-align:center"><font class="Apple-style-span" size="4"><b style="mso-bidi-font-weight:
normal"><span style="letter-spacing: 1.5pt; ">Modern Optics and Spectroscopy</span></b><span style="font-family:Arial;
mso-bidi-font-family:"Times New Roman";letter-spacing:1.5pt"><o:p></o:p></span></font></p><p class="MsoNormal" align="center" style="text-align:center"><b style="mso-bidi-font-weight:
normal"><span style="font-family: Arial; letter-spacing: 1pt; "><o:p><font class="Apple-style-span" size="4"> </font></o:p></span></b></p><p class="MsoBodyText"><span style="font-family:Times;mso-fareast-font-family:
"ＭＳ 明朝""><font class="Apple-style-span" size="4"><span class="Apple-tab-span" style="white-space:pre"> </span>Intracellular transport studied by dispersion-relation phase </font></span><span class="Apple-style-span" style="font-family: Times; font-size: large; ">spectroscopy (DPS)</span></p><p class="MsoNormal" align="center" style="text-align:center"><b style="mso-bidi-font-weight:
normal"><i style="mso-bidi-font-style:normal"><span style="letter-spacing: 1pt; "><o:p><font class="Apple-style-span" size="4"> </font></o:p></span></i></b></p><p class="MsoNormal" align="center" style="text-align:center"><font class="Apple-style-span" size="4"><b style="mso-bidi-font-weight:
normal">Gabriel
Popsecu</b><span style="letter-spacing: 1pt; ">,<o:p></o:p></span></font></p><p class="MsoNormal" align="center" style="text-align:center"><span style="letter-spacing: 1pt; "><font class="Apple-style-span" size="4">University
of Illinois at Urbana-Champaign</font></span></p><div><br></div><div><br></div><p class="MsoNormal" align="center" style="text-align:center"><span style="letter-spacing: 1pt; "><font class="Apple-style-span" size="4">Tuesday,
November 29, 2011<o:p></o:p></font></span></p><p class="MsoNormal" align="center" style="text-align:center"><span style="letter-spacing: 1pt; "><o:p><font class="Apple-style-span" size="4"> </font></o:p></span></p><p class="MsoNormal" align="center" style="text-align:center"><span style="letter-spacing: 1pt; "><font class="Apple-style-span" size="4">12:00 –
1:00 p.m.</font></span></p><p class="MsoNormal" style="text-align:justify"><font class="Apple-style-span" size="4"><span class="apple-style-span"><span style="color:black;background:white">The interior of a living cell is a busy
place. Molecular motors move materials along prescribed biopolymer tracks. This
sort of active transport is required to rapidly move products over large
distances within the cell, where passive diffusion is too slow. Just as understanding
the flow of traffic is essential for probing the economy of a major city,
exploring the intracellular traffic patterns of cells is fundamental to
elucidating their activity. </span></span>We examine intracellular traffic
patterns using a new application of spatial light interference microscopy
(SLIM). We used this quantitative phase imaging to measure the dispersion
relation, i.e. decay rate vs. spatial mode, associated with mass transport in
live cells. This approach applies equally well to both discrete and continuous
mass distributions without the need for particle tracking. From the quadratic
experimental curve specific to diffusion, we extracted the diffusion
coefficient as the only fitting parameter. The linear portion of the dispersion
relation reveals the deterministic component of the intracellular transport.
Our data show a universal behavior where the intracellular transport is
diffusive at small scales and deterministic at large scales. Measurements by
our method and particle tracking show that, on average, the mass transport in
the nucleus is slower than in the cytoplasm. We further applied this method to
studying transport in neurons. By modifying a traditional phase contrast
microscope, we are able to use SLIM to map the changes in index of refraction across
the neuron and its extended processes. What we found was that in dendrites and
axons, the transport is mostly active, i.e., diffusion is subdominant.<o:p></o:p></font></p><p class="MsoNormal" align="center" style="text-align:center"><o:p><font class="Apple-style-span" size="4"> </font></o:p></p><p class="MsoNormal" align="center" style="text-align:center"><font class="Apple-style-span" size="4">Grier Room, MIT Bldg 34-401<o:p></o:p></font></p><p class="MsoNormal" align="center" style="text-align:center"><font class="Apple-style-span" size="4">Refreshments served after the lecture</font><font class="Apple-style-span" size="5"><o:p></o:p></font></p>
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