<html><head></head><body style="word-wrap: break-word; -webkit-nbsp-mode: space; -webkit-line-break: after-white-space; "><!--StartFragment--><div style="margin-top: 0in; margin-right: -0.5in; margin-left: 2in; margin-bottom: 0.0001pt; text-align: left; text-indent: 0.5in; "><span style="font-family:"Times New Roman""><b><font class="Apple-style-span" size="3"><span class="Apple-style-span" style="font-size: 13px;"><span class="Apple-tab-span" style="white-space:pre"> </span>Seminar on</span></font></b></span></div><p class="MsoNormal" align="center" style="text-align:center"><span style="letter-spacing: 1.5pt; "><b><font class="Apple-style-span" size="3"><span class="Apple-style-span" style="font-size: 13px;">Modern Optics and Spectroscopy</span></font><font class="Apple-style-span" size="3"><span class="Apple-style-span" style="font-size: 13px;"><o:p></o:p></span></font></b></span></p>
<div class="MsoNormal"><span style="font-family: Arial; letter-spacing: 1pt; "><b><font class="Apple-style-span" size="3"><span class="Apple-style-span" style="font-size: 13px;"> </span></font><font class="Apple-style-span" size="3"><span class="Apple-style-span" style="font-size: 13px;"><o:p></o:p></span></font></b></span></div><p class="MsoNormal" align="center" style="text-align:center"><span style="font-family: Arial; letter-spacing: 1pt; "><b><font class="Apple-style-span" size="3"><span class="Apple-style-span" style="font-size: 13px;">Unexpected
insights into oriented cell motility using microfluidic tools</span></font></b></span><span style="letter-spacing: 1pt; "><b><i><font class="Apple-style-span" size="3"><span class="Apple-style-span" style="font-size: 13px;"><o:p></o:p></span></font></i></b></span></p><p class="MsoNormal" align="center" style="text-align:center"><span style="letter-spacing: 1pt; "><b><i><font class="Apple-style-span" size="3"><span class="Apple-style-span" style="font-size: 13px;"> </span></font></i></b></span></p><p class="MsoNormal" align="center" style="text-align:center"><b><font class="Apple-style-span" size="3"><span class="Apple-style-span" style="font-size: 13px;">Daniel Irimia</span></font></b><span style="letter-spacing: 1pt; "><font class="Apple-style-span" size="3"><span class="Apple-style-span" style="font-size: 13px;">, </span></font><font class="Apple-style-span" size="3"><span class="Apple-style-span" style="font-size: 13px;"><o:p></o:p></span></font></span></p><p class="MsoNormal" align="center" style="text-align:center"><span style="letter-spacing: 1pt; "><font class="Apple-style-span" size="3"><span class="Apple-style-span" style="font-size: 13px;">Massachusetts General Hospital, </span></font><font class="Apple-style-span" size="3"><span class="Apple-style-span" style="font-size: 13px;"><o:p></o:p></span></font></span></p><p class="MsoNormal" align="center" style="text-align:center"><span style="letter-spacing: 1pt; "><font class="Apple-style-span" size="3"><span class="Apple-style-span" style="font-size: 13px;">Harvard Medical School</span></font><font class="Apple-style-span" size="3"><span class="Apple-style-span" style="font-size: 13px;"><o:p></o:p></span></font></span></p>
<div class="MsoNormal"><span style="letter-spacing: 1pt; "><font class="Apple-style-span" size="3"><span class="Apple-style-span" style="font-size: 13px;"> </span></font><font class="Apple-style-span" size="3"><span class="Apple-style-span" style="font-size: 13px;"><o:p></o:p></span></font></span></div><p class="MsoNormal" align="center" style="text-align:center"><span style="letter-spacing: 1pt; "><font class="Apple-style-span" size="3"><span class="Apple-style-span" style="font-size: 13px;">Tuesday, November 30, 2010 </span></font></span></p><p class="MsoNormal" align="center" style="text-align:center"><span style="letter-spacing: 1pt; "><font class="Apple-style-span" size="3"><span class="Apple-style-span" style="font-size: 13px;">12:00 – 1:00 p.m.</span></font></span></p><p class="MsoNormal" style="text-align:justify;mso-pagination:none;mso-layout-grid-align:
none;text-autospace:none"><span style="font-family:Helvetica">O<font class="Apple-style-span" size="3"><span class="Apple-style-span" style="font-size: 13px;">riented cell
motility is a fundamental feature of living cells. Directional migration
of leukocytes against infections, epithelial repair during wound healing,
proper niche engraftment of stem cells, or directional motility of embryonic
cells during morphogenesis are all examples for the ability of cells to orient
and move in a chemotactic fields. In recent years, intense research
revealed many molecules and circuits responsible for oriented motility;
however, the cellular-scale mechanisms and the dynamics of interactions between
the signaling molecules remain elusive. To better understand the
mechanisms of oriented motility, we are employing novel microfluidic tools for
precise stimulations of moving cells and quantitative measurements of their
responses. We uncovered several unexpected responses of neutrophils
(white blood cells with critical roles in protecting us from bacterial
infections), like the delayed turning behavior in response to fast changes in
the direction of chemical gradients, the retrograde movement in response to
steep chemical gradients, or the tug of war at the front of the cell upon
combined chemical and mechanical challenges. We also extrapolated the use
of these tools towards the study of cancer cells and observed unexpectedly fast
and persistent migratory phenotype induced in conditions of mechanical
confinement. Moreover, we started exploring the utility of the novel
microfluidic tools to measure alterations of cell motility in disease
conditions and, in collaborations with medical teams, to probe the clinical
implications of cell motility in the context of infections, burn injuries, and
cancer metastasis.</span></font><font class="Apple-style-span" size="3"><span class="Apple-style-span" style="font-size: 13px;"><o:p></o:p></span></font></span></p><p class="MsoNormal" align="center" style="text-align:center"><span style="font-family: Helvetica; "><font class="Apple-style-span" size="3"><span class="Apple-style-span" style="font-size: 13px;"> </span></font></span><font class="Apple-style-span" size="3"><span class="Apple-style-span" style="font-size: 13px;"><o:p></o:p></span></font></p><p class="MsoNormal" align="center" style="text-align:center"><font class="Apple-style-span" size="3"><span class="Apple-style-span" style="font-size: 13px;">Grier Room, MIT Bldg 34-401</span></font><font class="Apple-style-span" size="3"><span class="Apple-style-span" style="font-size: 13px;"><o:p></o:p></span></font></p><p class="MsoNormal" align="center" style="text-align:center"><font class="Apple-style-span" size="3"><span class="Apple-style-span" style="font-size: 13px;">Refreshments served after the lecture</span></font><o:p></o:p></p>
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