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color="#000000"><b>Seminar on</b></font></div>
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color="#000000"><b>Modern Optics and Spectroscopy</b></font></div>
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<div align="center"><font face="Times New Roman"
color="#000000"><i><b>Detecting cervical pre-cancer with
"fluorectance" spectroscopy</b></i></font></div>
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<div align="center"><font face="Times New Roman"
color="#000000"><b>Jelena Mirkovic</b>, MIT</font></div>
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<div align="center"><font face="Times New Roman"
color="#000000">Tuesday, September 16, 2008</font></div>
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<div align="center"><font face="Times New Roman" color="#000000">12:00
- 1:00 p.m.</font></div>
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color="#000000">Cervical pre-cancer is currently diagnosed via
colposcopy, a procedure in which the cervix is inspected with a
low-power microscope and suspect tissue is then biopsied. Colposcopy
can accurately detect pre-cancerous cervical lesions, but it leads to
many unnecessary biopsies. The aim of our project is to develop a
spectroscopy-based tool for accurate detection of cervical pre-cancer
and improve the yield of biopsy. We collect tissue reflectance and
fluorescence with a portable, optical fiber instrument, to extract and
quantify biochemical and structural features of the tissue. We have
developed an accurate, site-specific algorithm for detecting
pre-cancer in the transformation zone, the region where the vast
majority of cervical lesions arise. Using optical methods, we have
extended our optical fiber detection technique to the imaging mode,
for wide-area tissue surveillance. An ongoing clinical imaging study
demonstrates the spectroscopic contrast between pre-cancerous and non
pre-cancerous cervical tissue.</font></div>
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<div align="center"><font face="Times New Roman" color="#000000">Grier
Room, MIT Bldg 34-401</font></div>
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color="#000000">Refreshments served after the lecture</font></div>
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