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<div><font face="Arial" color="#000000">Seminar on<br>
<b>Modern Optics and Spectroscopy<br>
<br>
<br>
Obrad Scepanovic</b>,<br>
MIT<br>
<br>
<i><b>Multimodal spectroscopy of vulnerable plaque<br>
<br>
</b></i>November 20, 2007<br>
<br>
12:00 - 1:00 p.m.</font></div>
<div><font face="Arial" color="#000000">Grier Room 34-401<br>
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color="#000000"><x-tab> </x-tab><br>
<br>
<br>
</font><font face="Times New Roman" color="#000000">The combination of
reflectance, fluorescence, and Raman spectroscopy - which we term
multimodal spectroscopy (MMS) - can provide complementary and
depth-sensitive information about tissue composition. We present an
overview of the development of MMS into a clinical technique for
detecting vulnerable atherosclerotic plaque, which is done through
four main areas. In the first, we show that MMS can provide spectral
markers indicative of the presence of morphological features of
vulnerable plaque. Having established the motivation, the next step
describes the mathematical tools used to extract quantitative spectral
parameters and, moreover, to assess the uncertainty and confidence of
the spectral information. In order to apply the mentioned methodology,
in the third step we describe the development of a compact and
practical clinical MMS instrument and an efficient, specialized MMS
probe for data acquisition. Lastly, we describe preliminary results
from a clinical study of vulnerable plaque as an important step in
clinical translation of the MMS technique.</font></div>
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