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<div id="mail-editor-reference-message-container">
<div id="mail-editor-reference-message-container">
<p class="MsoNormal"><b><span style="font-size:16.0pt;font-family:"Calibri",sans-serif">NCI Pathway to Independence Award for Outstanding Early-Stage Postdoctoral Researchers (K99/R00)</span></b><o:p></o:p></p>
<p class="MsoNormal"><b><span style="font-size:11.0pt;font-family:"Calibri",sans-serif"> </span></b><o:p></o:p></p>
<p class="MsoNormal"><b><span style="font-family:"Calibri",sans-serif">INTERNAL SUBMISSION DEADLINE<i>
</i><span style="color:#C00000">[EXTENDED]</span></span></b><o:p></o:p></p>
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<hr size="2" width="100%" align="center">
</div>
<p class="MsoNormal"><span style="font-family:"Calibri",sans-serif">Proposals due: August 3, 2026, 11:59 PM ET</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-family:"Calibri",sans-serif"> </span><o:p></o:p></p>
<p class="MsoNormal"><b><span style="font-family:"Calibri",sans-serif">FUNDING OPPORTUNITY DESCRIPTION</span></b><o:p></o:p></p>
<div class="MsoNormal" align="center" style="text-align:center">
<hr size="2" width="100%" align="center">
</div>
<p class="MsoNormal"><span style="font-family:"Calibri",sans-serif">The purpose of the
<span style="color:#467886"><a href="https://www.cancer.gov/grants-training/training/funding/early-k99"><span style="color:#467886">NCI Pathway to Independence Award for Outstanding Early-Stage Postdoctoral Researchers (K99/R00)</span></a></span> program is
to increase and maintain a strong cohort of new and talented, NCI-supported, independent investigators. This program is designed for
<b>postdoctoral fellows who do not require an extended period of mentored research career development beyond their doctoral degrees</b>. The objective of this award is to facilitate a timely transition of these fellows from their mentored, postdoctoral research
positions to independent, tenure-track or equivalent faculty positions.</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-family:"Calibri",sans-serif"> </span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-family:"Calibri",sans-serif;color:#0070C0"><a href="https://grants.nih.gov/grants/guide/pa-files/PAR-23-286.html"><b><i><span style="color:#0070C0">PAR-23-286</span></i></b></a></span><b><i><span style="font-family:"Calibri",sans-serif"> is
designed specifically for </span></i></b><b><span style="font-family:"Calibri",sans-serif">candidates<i> proposing research that
<u>does not</u> involve leading an independent clinical trial, a clinical trial feasibility study, or an ancillary study to a clinical trial.
</i></span></b><span style="font-family:"Calibri",sans-serif">Under this FOA candidates are permitted to propose research experience in a clinical trial led by a mentor or co-mentor.</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-family:"Calibri",sans-serif"> </span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-family:"Calibri",sans-serif;color:#0070C0"><a href="https://grants.nih.gov/grants/guide/pa-files/PAR-23-287.html"><b><i><span style="color:#0070C0">PAR-23-287</span></i></b></a></span><b><i><span style="font-family:"Calibri",sans-serif"> is
designed specifically for candidates proposing to serve as the lead investigator of an independent clinical trial, a clinical trial feasibility study, or a separate ancillary clinical trial</span></i></b><span style="font-family:"Calibri",sans-serif">.</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-family:"Calibri",sans-serif"> </span><o:p></o:p></p>
<p class="MsoNormal"><b><span style="font-family:"Calibri",sans-serif">AREAS OF RESEARCH SUPPORTED</span></b><o:p></o:p></p>
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<hr size="2" width="100%" align="center">
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<p class="MsoNormal"><b><span style="font-family:"Calibri",sans-serif">Each MIT application must represent a different Scientific Area:</span></b><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:Roboto"> </span><o:p></o:p></p>
<ol style="margin-top:0in" start="1" type="1">
<li class="MsoNormal" style="mso-list:l5 level1 lfo1"><b><i><span style="font-family:"Calibri",sans-serif">Cancer Data Science</span></i></b><i><span style="font-family:"Calibri",sans-serif">:</span></i><span style="font-family:"Calibri",sans-serif"> Cancer
data science is defined as an interdisciplinary field of inquiry in which quantitative and analytical approaches, processes, and systems are both developed and used to extract knowledge and insights from increasingly large and/or complex sets of data. This
includes cancer-focused data integration and visualization, systems biology, artificial intelligence, machine learning, informatics, genomics, precision oncology, and developing analytics for epidemiological or biostatistical studies.</span><o:p></o:p></li></ol>
<p class="MsoNormal"><span style="font-family:"Calibri",sans-serif"> </span><o:p></o:p></p>
<ol style="margin-top:0in" start="2" type="1">
<li class="MsoNormal" style="mso-list:l1 level1 lfo2"><b><i><span style="font-family:"Calibri",sans-serif">Cancer Control Science</span></i></b><i><span style="font-family:"Calibri",sans-serif">:</span></i><span style="font-family:"Calibri",sans-serif"> Cancer
control science is defined as basic and applied research in the behavioral, social, and population sciences to create or enhance interventions that, independently or in combination with biomedical approaches reduce cancer risk, incidence, morbidity, and mortality,
and improve quality of life. This includes research in epidemiology, behavioral sciences, health services, surveillance, cancer survivorship, and healthcare policy.</span><o:p></o:p></li></ol>
<p class="MsoNormal"><span style="font-family:"Calibri",sans-serif"> </span><o:p></o:p></p>
<ol style="margin-top:0in" start="3" type="1">
<li class="MsoNormal" style="mso-list:l0 level1 lfo3"><b><i><span style="font-family:"Calibri",sans-serif">Molecular/Precision Cancer Prevention</span></i></b><i><span style="font-family:"Calibri",sans-serif">:</span></i><span style="font-family:"Calibri",sans-serif"> Early
translational research in cancer prevention is defined as basic research to understand mechanisms of cancer formation, development and progression of cancer precursors, and to translate basic biological knowledge into novel human interventions and human-centered
adaption of current interventions with the potential to reduce cancer risk, incidence, and mortality, and improve quality of life. This includes but is not limited to research in molecular and systems biology, diagnostics, vaccine and drug development, pharmacology,
and biomedical engineering.</span><o:p></o:p></li></ol>
<p class="MsoNormal"><span style="font-family:"Calibri",sans-serif"> </span><o:p></o:p></p>
<ol style="margin-top:0in" start="4" type="1">
<li class="MsoNormal" style="mso-list:l2 level1 lfo4"><b><i><span style="font-family:"Calibri",sans-serif">Other Cancer Research</span></i></b><i><span style="font-family:"Calibri",sans-serif">:</span></i><span style="font-family:"Calibri",sans-serif"> "Other
Cancer Research" includes all scientific fields supported by the NCI that are not included in (A), (B) or (C). Applicants proposing research in (D) "Other Cancer Research" may apply only if it is reasonable to expect their candidates to transition to independence
with an abbreviated period of mentored research training beyond their original doctoral degrees."</span><o:p></o:p></li></ol>
<p class="MsoNormal"><b><span style="font-family:"Calibri",sans-serif"> </span></b><o:p></o:p></p>
<p class="MsoNormal"><b><span style="font-family:"Calibri",sans-serif">INTERNAL NOMINATION – MIT may nominate up to four applicants</span></b><o:p></o:p></p>
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</div>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:Roboto">MIT postdoctoral scholars wishing to pursue nominations should speak with their PI and submit the following materials as a single PDF to:
</span><span style="font-family:"Calibri",sans-serif;color:#0070C0"><a href="https://mitfunding.infoready4.com/#limitedsubmissions"><span style="color:#0070C0">https://mitfunding.infoready4.com</span></a></span><o:p></o:p></p>
<ul style="margin-top:0in" type="disc">
<li class="MsoNormal" style="mso-list:l3 level1 lfo5"><span style="font-family:"Calibri",sans-serif">Description of Research Proposal (2-page limit, not including references):</span><o:p></o:p></li></ul>
<ul style="margin-top:0in" type="disc">
<ul style="margin-top:0in" type="circle">
<li class="MsoNormal" style="mso-list:l3 level2 lfo5"><span style="font-family:"Calibri",sans-serif">Title;</span><o:p></o:p></li><li class="MsoNormal" style="mso-list:l3 level2 lfo5"><span style="font-family:"Calibri",sans-serif">Summary of the research;</span><o:p></o:p></li><li class="MsoNormal" style="mso-list:l3 level2 lfo5"><span style="font-family:"Calibri",sans-serif">Introduction, importance how the combination of past research experiences and the proposed K99/R00 plans will contribute to achieving the long-term career goal;</span><o:p></o:p></li><li class="MsoNormal" style="mso-list:l3 level2 lfo5"><span style="font-family:"Calibri",sans-serif">Research Strategy that clearly indicates the research planned for each phase and the significance, innovation and approach of the proposed research</span><o:p></o:p></li></ul>
</ul>
<ul style="margin-top:0in" type="disc">
<li class="MsoNormal" style="mso-list:l3 level1 lfo5"><span style="font-family:"Calibri",sans-serif">CV in NIH format</span><o:p></o:p></li><li class="MsoNormal" style="mso-list:l3 level1 lfo5"><span style="font-family:"Calibri",sans-serif">Letter of Support from PI (1-page limit);</span><o:p></o:p></li></ul>
<ul style="margin-top:0in" type="disc">
<ul style="margin-top:0in" type="circle">
<li class="MsoNormal" style="mso-list:l3 level2 lfo5"><span style="font-family:"Calibri",sans-serif">The candidate must identify a mentor who will supervise the proposed career development and research experience. The mentor should be an active investigator
in the area of the proposed research and be committed both to the career development of the candidate and to the direct supervision of the candidate’s research.</span><o:p></o:p></li></ul>
</ul>
<ul style="margin-top:0in" type="disc">
<li class="MsoNormal" style="mso-list:l3 level1 lfo5"><span style="font-family:"Calibri",sans-serif">Confirmation of eligibility from NCI (can be PDF of email correspondence)</span><o:p></o:p></li></ul>
<p class="MsoNormal"><b><span style="font-family:"Calibri",sans-serif"> </span></b><o:p></o:p></p>
<p class="MsoNormal"><b><span style="font-family:"Calibri",sans-serif">AMOUNT OF THE AWARD</span></b><o:p></o:p></p>
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</div>
<p class="MsoNormal"><b><span style="font-family:"Calibri",sans-serif">Please see the solicitation for full details.</span></b><o:p></o:p></p>
<p class="MsoNormal"><b><span style="font-family:"Calibri",sans-serif"> </span></b><o:p></o:p></p>
<p class="MsoNormal"><b><span style="font-family:"Calibri",sans-serif">Mentored Phase (K99)</span></b><span style="font-family:"Calibri",sans-serif">: NCI will contribute up to $100,000 per year toward the salary of the career award recipient. </span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-family:"Calibri",sans-serif"> </span><o:p></o:p></p>
<p class="MsoNormal"><b><span style="font-family:"Calibri",sans-serif">Independent Phase (R00)</span></b><span style="font-family:"Calibri",sans-serif">: The total cost for the independent phase (R00) may not exceed $249,000 per year. This amount includes salary,
fringe benefits, research costs, and applicable indirect costs.</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-family:"Calibri",sans-serif"> </span><o:p></o:p></p>
<p class="MsoNormal"><b><span style="font-family:"Calibri",sans-serif;text-transform:uppercase">Eligibility Requirements</span></b><o:p></o:p></p>
<div class="MsoNormal" align="center" style="text-align:center">
<hr size="2" width="100%" align="center">
</div>
<ul style="margin-top:0in" type="disc">
<li class="MsoNormal" style="mso-list:l4 level1 lfo6"><span style="font-family:"Calibri",sans-serif">Must have no more than 2 years of postdoctoral research experience as of the application due date</span><o:p></o:p></li><li class="MsoNormal" style="mso-list:l4 level1 lfo6"><span style="font-family:"Calibri",sans-serif">Must be in mentored, postdoctoral training positions to be eligible to apply to the K99/R00 program</span><o:p></o:p></li><li class="MsoNormal" style="mso-list:l4 level1 lfo6"><span style="font-family:"Calibri",sans-serif">Must have a clinical or research doctorate (including PhD, MD, or equivalent</span><o:p></o:p></li><li class="MsoNormal" style="mso-list:l4 level1 lfo6"><span style="font-family:"Calibri",sans-serif">Must have a “full-time” appointment at the applicant institution</span><o:p></o:p></li></ul>
<ul style="margin-top:0in" type="disc">
<ul style="margin-top:0in" type="circle">
<li class="MsoNormal" style="mso-list:l4 level2 lfo6"><span style="font-family:"Calibri",sans-serif">Candidates are required to commit a minimum of nine person months of effort (i.e., 75% of full-time professional effort) to their program of career development
during the mentored phase.</span><o:p></o:p></li></ul>
</ul>
<ul style="margin-top:0in" type="disc">
<li class="MsoNormal" style="mso-list:l4 level1 lfo6"><b><span style="font-family:"Calibri",sans-serif">R00 Phase:
</span></b><span style="font-family:"Calibri",sans-serif">Although candidates are required to devote no less than nine person months of effort (i.e., 75% of their full-time professional effort) to research, the required research effort need not be devoted exclusively
to the R00-supported research.</span><o:p></o:p></li></ul>
<p class="MsoNormal"><span style="font-family:"Calibri",sans-serif"> </span><o:p></o:p></p>
<p class="MsoNormal"><b><span style="font-family:"Calibri",sans-serif">Candidates for the NOFOs will be required to provide a confirmation of their eligibility from NCI as a part of the internal competition materials.</span></b><o:p></o:p></p>
<p class="MsoNormal"><b><span style="font-family:"Calibri",sans-serif"> </span></b><o:p></o:p></p>
<p class="MsoNormal"><b><span style="font-family:"Calibri",sans-serif">SUBMISSION DEADLINES</span></b><o:p></o:p></p>
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<p class="MsoNormal"><span style="font-family:"Calibri",sans-serif">Internal Nomination Due: August 3, 2026 at 11:59 PM ET</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-family:"Calibri",sans-serif">Proposal due to RAS: October 6, 2026 at 9:00 AM ET</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-family:"Calibri",sans-serif">Proposal due to Sponsor: October 14, 2026 at 5:00 PM ET</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-family:"Calibri",sans-serif"> </span><o:p></o:p></p>
<p class="MsoNormal"><b><span style="font-family:"Calibri",sans-serif">ADDITIONAL INFORMATION</span></b><o:p></o:p></p>
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<p class="MsoNormal"><b><span style="font-family:"Calibri",sans-serif">For selected applicants</span></b><span style="font-family:"Calibri",sans-serif">, a
<b>Nomination Letter is required, which must be written and signed by the head of the candidate’s postdoctoral department or program.
</b>Please refer to the “Other Attachments” section in the NOFOs for the contents of the letter.</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-family:"Calibri",sans-serif"> </span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-family:"Calibri",sans-serif">Please note MIT’s Committee on the Use of Humans as Experimental Subjects (COUHES) Guidance on Human Subjects Research:</span><o:p></o:p></p>
<ul style="margin-top:0in" type="disc">
<li class="MsoNormal" style="mso-list:l6 level1 lfo7"><span style="font-family:"Calibri",sans-serif">There are limitations on clinical trials at MIT which COUHES oversees. Please refer to the
<span style="color:#0070C0"><a href="https://couhes.mit.edu/clinical-trials-mit"><span style="color:#0070C0">guidance for clinical trials</span></a>
</span>for full details.</span><o:p></o:p></li><li class="MsoNormal" style="mso-list:l6 level1 lfo7"><span style="font-family:"Calibri",sans-serif">If after reviewing the guidelines on the
<span style="color:#0070C0"><a href="https://couhes.mit.edu/"><span style="color:#0070C0">COUHES website</span></a></span> for determining if the study is research, exempt research or requires full review is still unclear, the applicants should contact the
COUHES office staff for additional guidance.</span><o:p></o:p></li><li class="MsoNormal" style="mso-list:l6 level1 lfo7"><span style="font-family:"Calibri",sans-serif">If the applicants feel that the research is exempt, they can go through the exempt evaluation to determine if the study is exempt or needs full review.</span><o:p></o:p></li><li class="MsoNormal" style="mso-list:l6 level1 lfo7"><span style="font-family:"Calibri",sans-serif">COUHES can give IRB approval prior to a grant application or at any stage of the grant process. However, a specific Human Subjects Research protocol must be
ensured to give approval.</span><o:p></o:p></li><li class="MsoNormal" style="mso-list:l6 level1 lfo7"><span style="font-family:"Calibri",sans-serif">If multiple institutions are involved, please refer to the COUHES
<span style="color:#0070C0"><a href="https://couhes.mit.edu/single-irb-review"><span style="color:#0070C0">Single IRB Review</span></a>.</span></span><o:p></o:p></li><li class="MsoNormal" style="mso-list:l6 level1 lfo7"><span style="font-family:"Calibri",sans-serif">COUHES offers
<span style="color:#0070C0"><a href="https://couhes.mit.edu/about-couhes/dates-and-deadlines"><span style="color:#0070C0">virtual drop-in sessions</span></a></span> twice a week, Mondays and Wednesdays. No appointment is necessary. </span><o:p></o:p></li><li class="MsoNormal" style="mso-list:l6 level1 lfo7"><span style="font-family:"Calibri",sans-serif">If you have questions or are seeking additional guidance, please contact COUHES (<span style="color:#0070C0"><a href="mailto:couhes@mit.edu"><span style="color:#0070C0">couhes@mit.edu</span></a></span>)</span><o:p></o:p></li></ul>
<p class="MsoNormal"><span style="font-family:"Calibri",sans-serif"> </span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-family:"Calibri",sans-serif">This opportunity is being provided with the understanding that any proposal submissions must be reviewed to ensure compliance with MIT policies and procedures. Any subsequent awards will be
negotiated to ensure the inclusion of appropriate terms and conditions acceptable for an educational institution.</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-family:"Calibri",sans-serif"> </span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-family:"Calibri",sans-serif">Any questions about this solicitation or other institutionally limited submissions can be directed to
<span style="color:#0070C0"><a href="mailto:researchdev@mit.edu"><span style="color:#0070C0">researchdev@mit.edu</span></a></span>.</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-family:"Calibri",sans-serif"> </span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-family:"Calibri",sans-serif">All my best,</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-family:"Calibri",sans-serif">~ Danielle</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif"> </span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:Roboto"> </span><o:p></o:p></p>
<p class="MsoNormal"><b><span style="font-size:11.0pt;font-family:Roboto">Danielle Camp |
</span></b><span style="font-size:11.0pt;font-family:Roboto">Research Development Officer |
<span style="color:#1966FF"><a href="mailto:dcamp@mit.edu"><span style="color:#1966FF">dcamp@mit.edu</span></a></span><span style="color:#0563C1">
</span>| 617-324-4902</span><o:p></o:p></p>
<p class="MsoNormal"><b><span style="font-size:11.0pt;font-family:Roboto;color:#750014">Massachusetts Institute of Technology</span></b><b><span style="font-size:11.0pt;font-family:Roboto"> |
</span></b><span style="font-size:11.0pt;font-family:Roboto;color:#0563C1"><a href="https://ras.mit.edu/"><span style="color:#0563C1">Research Administration Services</span></a></span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:Roboto">NE18-901, 255 Main Street, Cambridge, MA 02139</span><o:p></o:p></p>
<p class="MsoNormal"> <o:p></o:p></p>
<p class="MsoNormal"> <o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Calibri",sans-serif">To search for funding opportunities using the PIVOT database, please go here:
<span style="color:#467886"><a href="https://pivot.proquest.com/dashboard"><span style="color:#467886">https://pivot.proquest.com/dashboard</span></a></span></span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Calibri",sans-serif"> </span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Calibri",sans-serif">To manage your subscription to the MITfundops Listserv, please visit:
<span style="color:#467886"><a href="http://mailman.mit.edu/mailman/listinfo/MITfundops%20"><span style="color:#467886">http://mailman.mit.edu/mailman/listinfo/MITfundops
</span></a></span> </span><o:p></o:p></p>
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