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<div style="font-size:13px"><b><span style="color:rgb(255,0,0)"><font
color="#000000">forwarded message:</font><br>
<br>
<br>
SPECIAL BIOPHYSICS SEMINAR</span><br>
</b></div>
<div style="font-size:13px"><span class="" tabindex="0"><span
class="">Tuesday Jan 6 at 4pm</span></span> in 32-144<b><br>
</b></div>
<div style="font-size:13px"><b><br>
Molecular recognition with nanoparticle conjugates for
label-free in vivo sensing applications</b><br>
Markita del Carpio Landry<br>
</div>
<p><span style="font-size:13px">Strano Lab</span><br
style="font-size:13px">
<span style="font-size:13px">Department of Chemical Engineering</span><br
style="font-size:13px">
<span style="font-size:13px">Massachusetts Institute of Technology</span><br>
</p>
<div style="font-size:13px">
<p class="MsoNormal" style="text-align:justify">Nanomaterials have
distinct optical, chemical, and mechanical properties that make
them useful for biomedical applications including the
development of highly sensitive and specific sensors of
biological activity. In particular, semiconducting single-wall
carbon nanotubes (SWNT) are unique near-infrared emitters,
making them well-suited for use as fluorescence-based optical
sensors: SWNT exhibit an extraordinary quantum yield, have
essentially infinite lifetimes, and emit in an optical window
where tissues, cells, blood, and other biological samples are
maximally transparent. We present several brief examples in
which SWNT have been instrumental in advancing technologies at
the interface of nanomaterial and molecular biosciences.</p>
<p class="MsoNormal" style="text-align:justify"><span
style="font-size:2pt"> </span></p>
<p class="MsoNormal" style="text-align:justify">Innovative
functionalization of SWNT with polymers can provide SWNT with
novel functions for a variety of applications. For instance, our
work has shown that we can impart sensing capabilities to SWNT
such that the SWNT-polymer conjugate produces a signature
optical signal in the presence of a specific analyte molecule
such as vitamin B2. Further development of these optical sensors
is promising for areas in need of sensors with high spatial and
temporal resolution, such as label-free detection of proteins
within a cell, point-of-care diagnostic tools, and nanoscale
therapeutics. The immediate utility of our optical sensors is
demonstrated by monitoring vitamin uptake into a living cell for
over an hour. We also successfully utilize this platform to
produce optical sensors for neurotransmitter detection and
visualize this process of molecular recognition on the
single-molecule scale. We further show the utility of
SWNT-polymer conjugates in the scope of “plant nanobionics”: the
detection of molecular pollutants inside living plants with a
dual-wavelength ratiometric signal. Future work will focus on
the real-time detection of protein expression, microbial
infections, deep tissue imaging, and kinetics of protein
misfolding.</p>
<span class=""><font color="#888888"><br>
<div>-- <br>
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<div><b><u style="color:rgb(0,0,0)">Jeff Gore
</u><u
style="color:rgb(0,0,0)"> </u></b><i><span
style="color:rgb(102,102,102)"><br>
</span></i><span style="color:rgb(102,102,102)"><b>Assistant
Professor<br>
Latham Family Career Development Professor</b></span><b><br
style="color:rgb(153,0,0)">
<span style="color:rgb(153,153,153)">Physics of
Living Systems<br>
</span></b></div>
<b><span style="color:rgb(153,153,153)">400 Technology
Square, <a href="http://whereis.mit.edu/?go=NE46"
target="_blank">NE46-609</a><br>
</span></b>
<div><b><span style="color:rgb(153,153,153)">Department
of Physics</span><br
style="color:rgb(153,153,153)">
<span style="color:rgb(153,153,153)">Massachusetts
Institute of Technology </span></b><br>
<span style="color:rgb(102,102,102)">Tel: <a
href="tel:%28617%29%20715-4251"
value="+16177154251" target="_blank">(617)
715-4251</a> | Fax: <a
href="tel:%28617%29%20258-6883"
value="+16172586883" target="_blank">(617)
258-6883</a></span><br
style="color:rgb(102,102,102)">
<a
href="http://web.mit.edu/physics/people/faculty/gore_jeff.html"
target="_blank" style="color:rgb(102,102,102)">MIT.edu/faculty</a><span
style="color:rgb(102,102,102)"> | </span><a
href="http://www.gorelab.org/" target="_blank"
style="color:rgb(102,102,102)">GORELab.org</a><span
style="color:rgb(102,102,102)"> | </span><a
href="http://www.jgore.org/" target="_blank"
style="color:rgb(102,102,102)">JGore.org</a><br>
<br>
Biophysicist? Join <a
href="http://www.aps.org/units/dbp/" target="_blank">DBIO</a> and
come to the APS <a
href="http://www.aps.org/meetings/march/"
target="_blank">March Meeting</a>!</div>
</div>
</div>
</div>
</font></span></div>
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