<html><body style="word-wrap: break-word; -webkit-nbsp-mode: space; -webkit-line-break: after-white-space; "><div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">======================================</font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">MIT Research Digest, April 2009</font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">======================================</font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; font: normal normal normal 12px/normal Helvetica; min-height: 14px; "><br></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">For Immediate Release</font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">3/31/2009</font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; font: normal normal normal 12px/normal Helvetica; min-height: 14px; "><br></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">Contact: Elizabeth A. Thomson, MIT News Office</font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">E: <a href="mailto:thomson@mit.edu">thomson@mit.edu</a>, T: 617-258-5402</font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; font: normal normal normal 12px/normal Helvetica; min-height: 14px; "><br></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; font: normal normal normal 12px/normal Helvetica; min-height: 14px; "><br></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">A monthly tip-sheet for journalists of recent research advances</font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">at the Massachusetts Institute of Technology.</font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; font: normal normal normal 12px/normal Helvetica; min-height: 14px; "><br></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">Latest research news: <a href="http://web.mit.edu/newsoffice/research.html">http://web.mit.edu/newsoffice/research.html</a></font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">RSS -- research feed: <a href="http://web.mit.edu/newsoffice/mitresearch-rss.xml">http://web.mit.edu/newsoffice/mitresearch-rss.xml</a></font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; font: normal normal normal 12px/normal Helvetica; min-height: 14px; "><br></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">IN THIS ISSUE: Nanostitching * Robotic Gardening * New Greenhouse Gas * Drug Delivery Gel * Climate Change & The Poor * Recognizing Faces * Toward Faster Microchips * Breast Cancer Test * Current Economic Crisis * Re-Engineered Battery Material * Older Workers * Harmless Intruder * Energy-Inefficient Manufacturing * Schizophrenia Advance * Transportation@Mit * Insights Into Blindness * Toward Engineering Tissues * Stem Cells * Mass Migrations</font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; font: normal normal normal 12px/normal Helvetica; min-height: 14px; "><br></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">NANOSTITCHING</font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">MIT engineers are using carbon nanotubes only billionths of a meter thick to stitch together aerospace materials in work that could make airplane skins and other products some 10 times stronger at a nominal increase in cost. Moreover, advanced composites reinforced with nanotubes are also more than one million times more electrically conductive than their counterparts without nanotubes, meaning aircraft built with such materials would have greater protection against damage from lightning, said Brian L. Wardle, the Charles Stark Draper Assistant Professor in the Department of Aeronautics and Astronautics. Wardle is lead author of a theoretical paper on the new nanotube-reinforced composites that will appear in the Journal of Composite Materials. He also described the work as keynote speaker at a recent Society of Plastics Engineers conference. This research was sponsored by MIT’s Nano-Engineered Composite aerospace STructures (NECST) Consortium.</font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">MORE: <a href="http://web.mit.edu/newsoffice/2009/nanostitching-0305.html">http://web.mit.edu/newsoffice/2009/nanostitching-0305.html</a></font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">PHOTO AND GRAPHIC AVAILABLE</font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; font: normal normal normal 12px/normal Helvetica; min-height: 14px; "><br></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">ROBOTIC GARDENING</font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">In the middle of MIT’s Computer Science and Artificial Intelligence Lab sits a platform of fake grass with tomato plants nestled in terra cotta pots, growing under the light of an artificial sun. But this urban, indoor garden has a twist: the caretakers of the plants are entirely robotic. The idea for tending to a garden without human hands came from work done by Nikolaus Correll, a postdoctoral assistant working in MIT Professor Daniela Rus’ Distributed Robotics Lab. Correll saw the possible applications of swarm robotics to an agricultural environment and thus the idea grew into a course in which students created robots capable of tending a small garden of tomatoes. Each robot is outfitted with a robotic arm and a watering pump, while the plants themselves are equipped with local soil sensing, networking and computation. This affords them the ability to communicate: plants can request water or nutrients and keep track of their conditions, including fruit produced; robots are able to minister to their charges, locate and pick a specific tomato, and even pollinate the plants.</font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">MORE: <a href="http://web.mit.edu/newsoffice/2009/robotic-garden-0318.html">http://web.mit.edu/newsoffice/2009/robotic-garden-0318.html</a></font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">PHOTO AVAILABLE</font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; font: normal normal normal 12px/normal Helvetica; min-height: 14px; "><br></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">NEW GREENHOUSE GAS</font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">A gas used for fumigation has the potential to contribute significantly to future greenhouse warming, but because its production has not yet reached high levels there is still time to nip this potential contributor in the bud, according to an international team of researchers. Scientists at MIT, the Scripps Institution of Oceanography in San Diego and other institutions report the results of their study of the gas, sulfuryl fluoride, in the Journal of Geophysical Research. The researchers have measured the levels of the gas in the atmosphere, and determined its emissions and lifetime to help gauge its potential future effects on climate. Sulfuryl fluoride was introduced as a replacement for methyl bromide, a widely used fumigant that is being phased out under the Montreal Protocol because of its ozone-destroying chemistry. Methyl bromide has been widely used for insect control in grain-storage facilities, and in intensive agriculture in arid lands where drip irrigation is combined with covering of the land with plastic sheets to control evaporation. “Such fumigants are very important for controlling pests in the agricultural and building sectors,” says Professor Ron Prinn, director of MIT’s Center for Global Change Science and a co-author on the new paper. But with methyl bromide being phased out, “industry had to find alternatives, so sulfuryl fluoride has evolved to fill the role,” he says. Until the new work, nobody knew accurately how long the gas would last in the atmosphere after it leaked out of buildings or grain silos. “Our analysis has shown that the lifetime is about 36 years, or eight times greater than previously thought, with the ocean being its dominant sink,” Prinn says.</font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">MORE: <a href="http://web.mit.edu/newsoffice/2009/prinn-greenhouse-tt0311.html">http://web.mit.edu/newsoffice/2009/prinn-greenhouse-tt0311.html</a></font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">PHOTO AVAILABLE</font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; font: normal normal normal 12px/normal Helvetica; min-height: 14px; "><br></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">DRUG DELIVERY GEL</font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">MIT researchers have demonstrated that a gel composed of small, woven protein fragments can successfully carry and release proteins of different sizes, potentially enabling delivery of drugs such as insulin and trastuzumab (Herceptin). Furthermore, the researchers can control the rate of release by changing the density of the gel, allowing for continuous drug delivery over a specific period of time. The team, led by Shuguang Zhang, associate director of MIT’s Center for Biomedical Engineering, reports its findings in the Proceedings of the National Academy of Sciences. The gel, known as a “nanofiber hydrogel scaffold,” enables, over hours, days or even months, a gradual release of the proteins from the gel, and the gel itself is eventually broken down into harmless amino acids — the building blocks of proteins. Traditional drug delivery systems are based on either synthetic polymer materials, which may contain residual chemicals and other cross-linking agents that are toxic for humans, or animal-derived collagen, which may contain residual growth and/or viruses from animal tissues. Peptide hydrogels are ideally suited for drug delivery as they are pure, easy to design and use, non-toxic, non-immunogenic, bio-absorbable, and can be locally applied to a particular tissue. The research was funded in part by the NIH and the HighQ Foundation.</font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">MORE: <a href="http://web.mit.edu/newsoffice/2009/drug-delivery-0309.html">http://web.mit.edu/newsoffice/2009/drug-delivery-0309.html</a></font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">PHOTO AVAILABLE</font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; font: normal normal normal 12px/normal Helvetica; min-height: 14px; "><br></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">CLIMATE CHANGE & THE POOR</font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">A rising tide is said to lift all boats. Rising global temperatures, however, may lead to increased disparities between rich and poor countries, according to a recent MIT economic analysis of the impact of climate change on growth. After examining worldwide climate and economic data from 1950 to 2003, Benjamin A. Olken, associate professor in the Department of Economics, concludes that a 1 degree Celsius rise in temperature in a given year reduces economic growth by an average of 1.1 percentage points in the world’s poor countries but has no measurable effect in rich countries. Olken says his research suggests higher temperatures will be disproportionately bad for the economic growth of poor countries compared to rich countries. The precise reasons why higher temperatures lower economic output are likely to be complex, but Olken’s results suggest the importance of temperature's impact on agricultural output. His data also provide evidence for a relationship between temperature and industrial output, investment, research productivity and political stability. “The potential impacts of an increase in temperature on poor countries are much larger than existing estimates have suggested,” Olken says. “Although historical estimates don’t necessarily predict the future, our results suggest that one should be particularly attentive to the potential impact of climate change on poorer countries.” Olken’s analysis is contained in “Climate Shocks and Economic Growth: Evidence from the Last Half Century,” a paper co-authored by MIT economics graduate student Melissa Dell and Benjamin F. Jones, associate management professor at Northwestern University.</font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">MORE: <a href="http://web.mit.edu/newsoffice/2009/climate-shock-0313.html">http://web.mit.edu/newsoffice/2009/climate-shock-0313.html</a></font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">PHOTO AVAILABLE</font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; font: normal normal normal 12px/normal Helvetica; min-height: 14px; "><br></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">RECOGNIZING FACES</font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">Humans excel at recognizing faces, but how we do this has been an abiding mystery in neuroscience and psychology. In an effort to explain our success in this area, researchers are taking a closer look at how and why we fail. A new study from MIT looks at a particularly striking instance of failure: our impaired ability to recognize faces in photographic negatives. The study, which appears in the Proceedings of the National Academy of Sciences, suggests that a large part of the answer might lie in the brain's reliance on a certain kind of image feature. The work could potentially lead to computer vision systems, for settings as diverse as industrial quality control or object and face detection. On a different front, the results and methodologies could help researchers probe face-perception skills in children with autism, who are often reported to experience difficulties analyzing facial information. The work was led by Pawan Sinha, an associate professor of brain and cognitive sciences and senior author of the study. It was funded by the Alfred P. Sloan Foundation and the Jim and Marilyn Simons Foundation.</font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">MORE: <a href="http://web.mit.edu/newsoffice/2009/brain-photo-0313.html">http://web.mit.edu/newsoffice/2009/brain-photo-0313.html</a></font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">PHOTO AVAILABLE</font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; font: normal normal normal 12px/normal Helvetica; min-height: 14px; "><br></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">TOWARD FASTER MICROCHIPS</font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">New research findings at MIT could lead to microchips that operate at much higher speeds than is possible with today’s standard silicon chips, leading to cell phones and other communications systems that can transmit data much faster. The key to the superfast chips is the use of a material called graphene, a form of pure carbon that was first identified in 2004. Researchers at other institutions have already used the one-atom-thick layer of carbon atoms to make prototype transistors and other simple devices, but the latest MIT results could open up a range of new applications. The MIT researchers built an experimental graphene chip known as a frequency multiplier, meaning it is capable of taking an incoming electrical signal of a certain frequency — for example, the clock speed that determines how fast a computer chip can carry out its computations — and producing an output signal that is a multiple of that frequency. In this case, the MIT graphene chip can double the frequency of an electromagnetic signal. Frequency multipliers are widely used in radio communications and other applications. But existing systems require multiple components, produce “noisy” signals that require filtering and consume large power, whereas the new graphene system has just a single transistor and produces, in a highly efficient manner, a clean output that needs no filtering. The findings are being reported in the May issue of Electron Device Letters and were also reported recently at an American Physical Society meeting by Tomás Palacios, assistant professor in MIT’s Department of Electrical Engineering and Computer Science and a core member of the Microsystems Technology Laboratories.This project is partially funded by the MIT Institute for Soldier Nanotechnologies and by the Interconnect Focus Center program.</font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">MORE: <a href="http://web.mit.edu/newsoffice/2009/graphene-palacios-0319.html">http://web.mit.edu/newsoffice/2009/graphene-palacios-0319.html</a></font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">PHOTO AVAILABLE</font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; font: normal normal normal 12px/normal Helvetica; min-height: 14px; "><br></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">BREAST CANCER TEST</font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">Scientists at MIT, the Albert Einstein College of Medicine and Weill Cornell Medical School have developed a test that could help doctors precisely identify which breast cancer patients should receive aggressive therapy, thereby sparing many women at low risk for metastatic disease from undergoing unnecessary and potentially dangerous treatment. The researchers, including MIT biology professor Frank Gertler, developed the test based on an earlier finding that the co-mingling of three cell types can predict whether localized breast cancer will metastasize, or spread throughout the body. The findings are published March 24 in the online version of Clinical Cancer Research. “This is the first marker that can reliably predict metastatic breast cancer,” says study co-author John S. Condeelis, professor and co-chair of anatomy and structural biology at Yeshiva University’s Albert Einstein College of Medicine. “It could dramatically change the way we approach the care of women with breast cancer.”</font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">MORE: <a href="http://web.mit.edu/newsoffice/2009/cancer-test-0324.html">http://web.mit.edu/newsoffice/2009/cancer-test-0324.html</a></font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; font: normal normal normal 12px/normal Helvetica; min-height: 14px; "><br></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">CURRENT ECONOMIC CRISIS</font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">Economists and policy-makers alike are trying to assess why risk-management systems and regulatory constraints didn't kick in before the global economy became so weak. To most, this situation is a shock. Economist Andrew Lo is less surprised. A professor at the MIT Sloan School of Management, Lo has studied the connections between financial decision-making, neuroscience and evolutionary psychology. His ideas about human behavior in financial markets have attracted the attention of policymakers in Washington who want not only to sort out the current crisis but also to head off future destructive events. Testifying before the House Oversight Committee last November, Lo discussed how credit crises have been regular occurrences over the past 35 years. "Financial crises are an unfortunate but necessary consequence of modern capitalism," he explained. Financial losses, he added, are a byproduct of innovation, "but disruptions and dislocations are greatly magnified when risks have been incorrectly assessed and incorrectly assigned." Lo believes that "behavioral blind spots" -- evolutionarily hardwired reactions to perceived risks and rewards -- are particularly dangerous during periods of economic extreme. That is, during both bubbles and crashes.</font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">MORE: <a href="http://web.mit.edu/newsoffice/2009/lo-interview-0323.html">http://web.mit.edu/newsoffice/2009/lo-interview-0323.html</a></font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; font: normal normal normal 12px/normal Helvetica; min-height: 14px; "><br></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">RE-ENGINEERED BATTERY MATERIAL</font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">MIT engineers have created a kind of beltway that allows for the rapid transit of electrical energy through a well-known battery material, an advance that could usher in smaller, lighter batteries — for cell phones and other devices — that could recharge in seconds rather than hours. The work could also allow for the quick recharging of batteries in electric cars, although that particular application would be limited by the amount of power available to a homeowner through the electric grid. The work, led by Gerbrand Ceder, the Richard P. Simmons Professor of Materials Science and Engineering, is reported in the March 12 issue of Nature. Because the material involved is not new — the researchers have simply changed the way they make it — Ceder believes the work could make it into the marketplace within two to three years. This work was supported by the NSF and the DOE.</font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">MORE: <a href="http://web.mit.edu/newsoffice/2009/battery-material-0311.html">http://web.mit.edu/newsoffice/2009/battery-material-0311.html</a></font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">PHOTO AVAILABLE</font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; font: normal normal normal 12px/normal Helvetica; min-height: 14px; "><br></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">OLDER WORKERS</font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">If long-term job market trends continue, the person asking, “Do you want fries with that?” will be increasingly likely to have a college education, an MIT analysis finds. Dramatic shifts in the U.S. labor market in the last 25 years are relegating older workers — even those with a college education — to lower-wage jobs, according to research by MIT Economics Professor David Autor. This trend appears likely to steepen in the current recession, as employers accelerate the rate at which they shed nonessential positions. In a paper co-authored with graduate student David Dorn, “This Job is ‘Getting Old’: Measuring Change in Job Opportunities using Occupational Age Structure,” which was presented recently at the American Economics Association conference, Autor analyzes a phenomenon that he refers to as the “hollowing out” of the U.S. job market from 1980 to 2005. “One of the most remarkable developments in the U.S. labor market of the past two and a half decades has been the rapid, simultaneous growth of employment in both the highest- and lowest-skilled jobs,” Autor says. European labor markets echo this shift.</font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">MORE: <a href="http://web.mit.edu/newsoffice/2009/oldjobs-0310.html">http://web.mit.edu/newsoffice/2009/oldjobs-0310.html</a></font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; font: normal normal normal 12px/normal Helvetica; min-height: 14px; "><br></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">HARMLESS INTRUDER</font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">On March 2, an asteroid whizzed past the Earth at a distance of just 41,000 miles -- a near miss by cosmic standards (most communications satellites orbit at a distance of about 22,300 miles from Earth). Headlines around the world proclaimed that Earth had dodged a bullet, and many mentioned that if the space rock had hit our planet, it might have packed a punch comparable to the Tunguska impact in 1908 that flattened trees over an 800-square-mile area in Siberia. But some fast-tracking observations by MIT Professor of Planetary Sciences Richard Binzel proved that this rock was actually much smaller than that. Likely just 19 meters (about 60 feet) across, it would probably have disintegrated high in the atmosphere, with only a few small fragments making it to the ground. Discovered just two days before its closest approach to Earth, the asteroid, called 2009 DD45, was initially estimated as between 20 and 40 meters across. At the high end, that would have made it comparable to the devastating Tunguska bolide.</font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">MORE: <a href="http://web.mit.edu/newsoffice/2009/harmless-intruder-0316.html">http://web.mit.edu/newsoffice/2009/harmless-intruder-0316.html</a></font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; font: normal normal normal 12px/normal Helvetica; min-height: 14px; "><br></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">ENERGY-INEFFICIENT MANUFACTURING</font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">Modern manufacturing methods are spectacularly inefficient in their use of energy and materials, according to a detailed MIT analysis of the energy use of 20 major manufacturing processes. Overall, new manufacturing systems are anywhere from 1,000 to one million times bigger consumers of energy, per pound of output, than more traditional industries. In short, pound for pound, making microchips uses up orders of magnitude more energy than making manhole covers. At first glance, it may seem strange to make comparisons between such widely disparate processes as metal casting and chip making. But Professor Timothy Gutowski of MIT’s Department of Mechanical Engineering, who led the analysis, explains that such a broad comparison of energy efficiency is an essential first step toward optimizing these newer manufacturing methods as they gear up for ever-larger production. “The seemingly extravagant use of materials and energy resources by many newer manufacturing processes is alarming and needs to be addressed alongside claims of improved sustainability from products manufactured by these means,” Gutowksi and colleagues say in their conclusion to the study, which was recently published in the journal Environmental Science and Technology. The work was funded by the NSF.</font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">MORE: <a href="http://web.mit.edu/newsoffice/2009/energy-manufacturing-0317.html">http://web.mit.edu/newsoffice/2009/energy-manufacturing-0317.html</a></font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">PHOTO AVAILABLE</font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; font: normal normal normal 12px/normal Helvetica; min-height: 14px; "><br></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">SCHIZOPHRENIA ADVANCE</font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">Researchers at MIT’s Picower Institute for Learning and Memory have found that inhibiting a key brain enzyme in mice reversed schizophrenia-like symptoms. The finding, reported in the March 20 issue of Cell, identified how a particular gene controls this brain enzyme. Better understanding of the relationship could lead to new drug treatments for schizophrenia, the severe brain disorder that affects about 1 percent of the population and is characterized by hallucinations, delusions, poor social and emotional functioning and disorganized thoughts. The Picower research focused on a gene known as DISC1 (short for “disrupted in schizophrenia 1”). DISC1 has since been shown to help brain neuronal cells migrate to their correct positions and to help new neurons grow in the developing brain, but its role was not well understood. Now, Li-Huei Tsai, the Picower Professor of Neuroscience in MIT’s Department of Brain and Cognitive Sciences, and colleagues have shown for the first time that DISC1 directly inhibits the activity of a brain enzyme called glycogen synthase kinase 3 beta, also known as GSK3B. Lithium chloride, the mood-stabilizing drug often prescribed for schizophrenia and bipolar disorder, also acts on GSK3B. “This work for the first time provides a detailed explanation of how DISC1 functions normally in our brains,” said Tsai, a Howard Hughes Medical Institute investigator and director of the neurobiology program of the Stanley Center for Psychiatric Research at the Broad Institute of Harvard and MIT.This work was supported by the NIH, the Stanley Center, the National Alliance for Research on Schizophrenia and Depression (NARSAD) and the Human Frontier Science Program.</font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">MORE: <a href="http://web.mit.edu/newsoffice/2009/disc1-0319.html">http://web.mit.edu/newsoffice/2009/disc1-0319.html</a></font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; font: normal normal normal 12px/normal Helvetica; min-height: 14px; "><br></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">TRANSPORTATION@MIT</font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">MIT has launched Transportation@MIT, a coordinated effort to address one of civilization’s most pressing challenges: the environmental impact of the world’s ever-increasing demand for transportation. Building on MIT’s rich tradition of engineering research and interdisciplinary collaboration, the new initiative will knit together the wide-ranging, robust research already under way at the Institute and create new opportunities for education and innovation. The program’s creation comes as the global movement of people and things becomes increasingly unsustainable — a problem that cannot be pinned on any one mode of transport. Two-thirds of the world’s petroleum consumption is taken up by transportation-related needs. Projections indicate that demand for petroleum, if unchecked, may outstrip supply within a few decades, while carbon dioxide output across the globe could triple by 2050. “The global transportation challenge is as multi-faceted as a problem could be, and it is hard to think of an institution better equipped to tackle it than MIT,” said Dean of Engineering Subra Suresh.</font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">MORE: <a href="http://web.mit.edu/newsoffice/2009/transportation-0304.html">http://web.mit.edu/newsoffice/2009/transportation-0304.html</a></font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; font: normal normal normal 12px/normal Helvetica; min-height: 14px; "><br></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">INSIGHTS INTO BLINDNESS</font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">In macular degeneration, the most common form of adult blindness, patients progressively lose vision in the center of their visual field, thereby depriving the corresponding part of the visual cortex of input. Previously, researchers discovered that the deprived neurons begin responding to visual input from another spot on the retina — evidence of plasticity in the adult cortex. Just how such plasticity occurred was unknown, but a new MIT study sheds light on the underlying neural mechanism. “This study shows us one way that the brain changes when its inputs change. Neurons seem to ‘want’ to receive input: when their usual input disappears, they start responding to the next best thing,” said Nancy Kanwisher of the McGovern Institute for Brain Research at MIT and senior author of the study appearing in a March issue of the Journal of Neuroscience. “Our study shows that the changes we see in neural response in people with MD are probably driven by the lack of input to a population of neurons, not by a change in visual information processing strategy,” said Kanwisher, the Ellen Swallow Richards Professor of Cognitive Neuroscience in MIT’s Department of Brain and Cognitive Sciences. This work was supported by the NIH, Kirschstein-NRSA, and Dr. and Mrs. Joseph Byrne.</font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">MORE: <a href="http://web.mit.edu/newsoffice/2009/macular-degen-0303.html">http://web.mit.edu/newsoffice/2009/macular-degen-0303.html</a></font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">PHOTO AND GRAPHIC AVAILABLE</font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; font: normal normal normal 12px/normal Helvetica; min-height: 14px; "><br></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">TOWARD ENGINEERING TISSUES</font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">As a high school sophomore, Asad Moten read a news story about engineering new organs for patients waiting for a transplant, and decided to start his own tissue-engineering project. His efforts led to the invention of a scaffold that can help regenerate tissue and that may one day be able to help patients with spinal cord injuries, serious burns, nerve defects and other chronic wounds. The invention, known as a protein printboard, may also lead to methods to engineer transplantable organs, which could help some of the 80,000 people in the United States waiting for donated organs. "Twenty of these patients die every day due to a lack of replacement organs and tissues for them," says Moten, who is forming a startup, ECMatrix Inc., to develop tissue replacement scaffolds. Moten's invention has won him numerous awards and accolades, the most recent being an induction into the Young Inventor's International Hall of Fame. He was also a regional finalist in the 2006-2007 Siemens Westinghouse Competition. He is now a sophomore at MIT majoring in brain and cognitive sciences and biological engineering.</font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">MORE: <a href="http://web.mit.edu/newsoffice/2009/wound-heal-0304.html">http://web.mit.edu/newsoffice/2009/wound-heal-0304.html</a></font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">PHOTO AVAILABLE</font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; font: normal normal normal 12px/normal Helvetica; min-height: 14px; "><br></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">STEM CELLS</font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">MIT and Whitehead Institute researchers have developed a novel method of removing potential cancer-causing genes during the reprogramming of skin cells from Parkinson's disease patients into an embryonic-stem-cell-like state. Scientists were then able to use the resulting induced pluripotent stem (iPS) cells to derive dopamine-producing neurons, the cell type that degenerates in Parkinson's disease patients. The work marks the first time researchers have generated human iPS cells that have maintained their embryonic stem-cell-like properties after the removal of reprogramming genes. The findings are published in the March 6 edition of the journal Cell. "Until this point, it was not completely clear that when you take out the reprogramming genes from human cells, the reprogrammed cells would actually maintain the iPS state and be self-perpetuating," says Frank Soldner, a postdoctoral researcher in Whitehead Member and MIT Professor Rudolf Jaenisch's laboratory and co-author of the article.</font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">MORE: <a href="http://web.mit.edu/newsoffice/2009/parkinsons-stem-0305.html">http://web.mit.edu/newsoffice/2009/parkinsons-stem-0305.html</a></font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">PHOTO AVAILABLE</font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; font: normal normal normal 12px/normal Helvetica; min-height: 14px; "><br></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">MASS MIGRATIONS</font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">For the first time, MIT engineers and colleagues have observed the initiation of a mass gathering and subsequent migration of hundreds of millions of animals — in this case, fish. The work, conducted using a novel imaging technique, “provides information essential to the conservation of marine ecosystems that vast oceanic fish shoals inhabit,” the team writes in the March 27 issue of Science. It also confirms theories about the behavior of large groups of animals in general, from bird flocks to locust swarms. Until now those theories had only been predicted through theoretical investigations, computer simulations and laboratory experiments. For example, the team found that once a group of fish reaches a critical population density, it triggers a kind of chain reaction resulting in the synchronized movement of millions of individuals over a large area. The phenomenon is akin to a human “wave” moving around a sports stadium. “As far as we know, this is the first time we’ve quantified this behavior in nature and over such a huge ecosystem,” said Nicholas C. Makris, leader of the work and a professor of mechanical and ocean engineering. The work was sponsored by the National Oceanographic Partnership Program, the Office of Naval Research, and the Alfred P. Sloan Foundation, and is a contribution to the Census of Marine Life.</font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">MORE: <a href="http://web.mit.edu/newsoffice/2009/animal-behavior-0326.html">http://web.mit.edu/newsoffice/2009/animal-behavior-0326.html</a></font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">PHOTO, VIDEO AND GRAPHIC AVAILABLE</font></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Helvetica" size="3" style="font: 12.0px Helvetica">--END--</font></div> </div></body></html>