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<p class=MsoNormal><b><span style='font-family:"Calibri","sans-serif"'>Spring
2010 Seminar Series on Computational and Systems Biology & Biophysics</span></b><b><span
style='font-family:"Calibri","sans-serif";color:windowtext'><o:p></o:p></span></b></p>
<p class=MsoNormal><span style='font-family:"Calibri","sans-serif"'>Friday, April
16, 2010<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-family:"Calibri","sans-serif"'>3:00 pm
– 4:00 pm<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-family:"Calibri","sans-serif"'>Room 32-155<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-family:"Calibri","sans-serif"'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-family:"Calibri","sans-serif"'>Presenting:<o:p></o:p></span></p>
<p class=MsoNormal><b><span style='font-family:"Calibri","sans-serif";
color:windowtext'>Randomness and predictability of cellular response in
bacteria<o:p></o:p></span></b></p>
<p class=MsoNormal><span style='font-family:"Calibri","sans-serif"'>
<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-family:"Calibri","sans-serif"'>Professor Philippe
Cluzel<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-family:"Calibri","sans-serif"'>Department
of Molecular and Cell Biology<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-family:"Calibri","sans-serif"'>Harvard
University<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-family:"Calibri","sans-serif"'> <o:p></o:p></span></p>
<p class=MsoNormal><span style='font-family:"Calibri","sans-serif";color:windowtext'>Abstract:
<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-family:"Calibri","sans-serif";color:windowtext'>In
light of the diversity and the complexity of living systems in nature, it
is fair to ask whether even the best-characterized biological phenomena
can be described using first physical principles. Examining several
theoretical and experimental examples, I will discuss how E. coli
bacteria use simple intracellular networks, composed of just a few
components, to perform essential biological computations, such as adaptation
and response to environmental perturbations. The study of the dynamics of these
simple networks not only highlights a general connection between
stochastic events within the networks and the evolution of cellular
response, but it should also help identify basic design principles of
other more complex biological systems.<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-family:"Calibri","sans-serif"'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-family:"Calibri","sans-serif"'> Light
refreshments to be served at 2:45 pm<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-family:"Calibri","sans-serif"'> Host:
Alexander van Oudenaarden (<a href="mailto:avo1@mit.edu"><span
style='color:windowtext'>avo1@mit.edu</span></a>), Department of Physics and
Biology<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-family:"Calibri","sans-serif"'><o:p> </o:p></span></p>
<p class=MsoNormal><b><span style='font-family:"Calibri","sans-serif";
color:windowtext'><o:p> </o:p></span></b></p>
<p class=MsoNormal><span style='font-family:"Calibri","sans-serif";color:windowtext'><o:p> </o:p></span></p>
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