<html xmlns:v="urn:schemas-microsoft-com:vml" xmlns:o="urn:schemas-microsoft-com:office:office" xmlns:w="urn:schemas-microsoft-com:office:word" xmlns:m="http://schemas.microsoft.com/office/2004/12/omml" xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv=Content-Type content="text/html; charset=us-ascii">
<meta name=Generator content="Microsoft Word 12 (filtered medium)">
<style>
<!--
/* Font Definitions */
@font-face
{font-family:"Cambria Math";
panose-1:2 4 5 3 5 4 6 3 2 4;}
@font-face
{font-family:Calibri;
panose-1:2 15 5 2 2 2 4 3 2 4;}
@font-face
{font-family:Tahoma;
panose-1:2 11 6 4 3 5 4 4 2 4;}
@font-face
{font-family:Consolas;
panose-1:2 11 6 9 2 2 4 3 2 4;}
/* Style Definitions */
p.MsoNormal, li.MsoNormal, div.MsoNormal
{margin:0in;
margin-bottom:.0001pt;
font-size:11.0pt;
font-family:"Calibri","sans-serif";}
a:link, span.MsoHyperlink
{mso-style-priority:99;
color:blue;
text-decoration:underline;}
a:visited, span.MsoHyperlinkFollowed
{mso-style-priority:99;
color:purple;
text-decoration:underline;}
p.MsoPlainText, li.MsoPlainText, div.MsoPlainText
{mso-style-priority:99;
mso-style-link:"Plain Text Char";
margin:0in;
margin-bottom:.0001pt;
font-size:10.5pt;
font-family:Consolas;}
span.PlainTextChar
{mso-style-name:"Plain Text Char";
mso-style-priority:99;
mso-style-link:"Plain Text";
font-family:Consolas;}
span.EmailStyle19
{mso-style-type:personal;
font-family:"Calibri","sans-serif";
color:windowtext;}
span.EmailStyle20
{mso-style-type:personal-reply;
font-family:"Calibri","sans-serif";
color:#1F497D;}
.MsoChpDefault
{mso-style-type:export-only;
font-size:10.0pt;}
@page Section1
{size:8.5in 11.0in;
margin:1.0in 1.0in 1.0in 1.0in;}
div.Section1
{page:Section1;}
-->
</style>
<!--[if gte mso 9]><xml>
<o:shapedefaults v:ext="edit" spidmax="1026" />
</xml><![endif]--><!--[if gte mso 9]><xml>
<o:shapelayout v:ext="edit">
<o:idmap v:ext="edit" data="1" />
</o:shapelayout></xml><![endif]-->
</head>
<body lang=EN-US link=blue vlink=purple>
<div class=Section1>
<p class=MsoNormal><b><span style='color:#1F497D'><o:p> </o:p></span></b></p>
<p class=MsoNormal><b>Fall 2009 Seminar Series on Computational and Systems
Biology<o:p></o:p></b></p>
<p class=MsoNormal>Friday, November 13, 2009<o:p></o:p></p>
<p class=MsoNormal>3:00 pm – 4:00 pm<o:p></o:p></p>
<p class=MsoNormal>Room 32-463D<o:p></o:p></p>
<p class=MsoNormal><o:p> </o:p></p>
<p class=MsoNormal>Presenting:<o:p></o:p></p>
<p class=MsoPlainText><b><span style='font-size:11.0pt;font-family:"Calibri","sans-serif"'>Understanding
non-genetic heterogeneity in cells <o:p></o:p></span></b></p>
<p class=MsoNormal>
<o:p></o:p></p>
<p class=MsoNormal>Professor Johan Paulsson<o:p></o:p></p>
<p class=MsoNormal>Department of Systems Biology<o:p></o:p></p>
<p class=MsoNormal>Harvard Medical School<o:p></o:p></p>
<p class=MsoNormal> <o:p></o:p></p>
<p class=MsoPlainText><span style='font-size:11.0pt;font-family:"Calibri","sans-serif"'>Life
in single cells is dictated by chance: Reactions that involve small numbers of
molecules generate spontaneous fluctuations that enslave all dependent
processes. Such 'noise' can randomize developmental pathways, disrupt cell
cycle control or force metabolites away from their optimal levels. It can also
be exploited for advantageous heterogeneity or even for more deterministic
control. I will discuss new concepts and analytical frameworks that enable us
to analyze such processes, addressing many of the complications and challenges
in cellular dynamics while at the same time promoting intuition and
facilitating comparisons with experiments. The principles discussed will be
illustrated with homeostatic feedback control, partitioning at cell division,
stochastic gene expression, multimerization, and small RNAs. <o:p></o:p></span></p>
<p class=MsoNormal><o:p> </o:p></p>
<p class=MsoNormal> Light refreshments to be served at 2:45 pm<o:p></o:p></p>
<p class=MsoNormal> Host: Alexander van Oudenaarden (<a
href="mailto:avo1@mit.edu"><span style='color:windowtext'>avo1@mit.edu</span></a>),
Department of Physics and Biology<o:p></o:p></p>
<p class=MsoNormal><o:p> </o:p></p>
</div>
</body>
</html>