<!DOCTYPE HTML PUBLIC "-//W3C//DTD HTML 4.0 Transitional//EN">
<HTML><HEAD>
<META http-equiv=Content-Type content="text/html; charset=iso-8859-1">
<META content="MSHTML 6.00.6000.16640" name=GENERATOR>
<STYLE></STYLE>
</HEAD>
<BODY bgColor=#ffffff>
<P class=MsoNormal><B><FONT face=Garamond size=5><SPAN
style="FONT-WEIGHT: bold; FONT-SIZE: 18pt; FONT-FAMILY: Garamond">Spring 2008
Seminar Series on Computational and Systems Biology<?xml:namespace prefix = o ns
= "urn:schemas-microsoft-com:office:office" /><o:p></o:p></SPAN></FONT></B></P>
<P class=MsoNormal><FONT face=Garamond size=3><SPAN
style="FONT-SIZE: 12pt; FONT-FAMILY: Garamond">Friday, April 25,
2008<o:p></o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT face=Garamond size=3><SPAN
style="FONT-SIZE: 12pt; FONT-FAMILY: Garamond">3:00 pm – 4:00
pm<o:p></o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT face=Garamond size=3><SPAN
style="FONT-SIZE: 12pt; FONT-FAMILY: Garamond">Room
3-270<o:p></o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT face=Garamond size=3><SPAN
style="FONT-SIZE: 12pt; FONT-FAMILY: Garamond"><o:p></o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT face=Garamond size=3><SPAN
style="FONT-SIZE: 12pt; FONT-FAMILY: Garamond"><o:p></o:p></SPAN></FONT></P>
<P class=MsoNormal><B><I><FONT face=Garamond size=3><SPAN
style="FONT-WEIGHT: bold; FONT-SIZE: 12pt; FONT-STYLE: italic; FONT-FAMILY: Garamond">Presenting:<o:p></o:p></SPAN></FONT></I></B></P>
<P class=MsoNormal><FONT face=Garamond size=3><SPAN
style="FONT-SIZE: 12pt; FONT-FAMILY: Garamond">Professor Ned
Wingreen<o:p></o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT face=Garamond size=3><SPAN
style="FONT-SIZE: 12pt; FONT-FAMILY: Garamond">Department of Molecular
Biology<BR><?xml:namespace prefix = st1 ns =
"urn:schemas-microsoft-com:office:smarttags" /><st1:place
w:st="on"><st1:PlaceName w:st="on">Princeton</st1:PlaceName> <st1:PlaceType
w:st="on">University</st1:PlaceType></st1:place><o:p></o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT face=Garamond size=3><SPAN
style="FONT-SIZE: 12pt; FONT-FAMILY: Garamond"><o:p> </o:p></SPAN></FONT><FONT
face=Garamond size=3><SPAN style="FONT-SIZE: 12pt; FONT-FAMILY: Garamond">Title:
<STRONG>“<SPAN style="FONT-STYLE: italic">Modeling adaptation in E. coli
chemotaxis: precise, robust, and
optimized”</SPAN><o:p></o:p></STRONG></SPAN></FONT></P>
<P class=MsoNormal><FONT face=Garamond size=3><SPAN
style="FONT-SIZE: 12pt; FONT-FAMILY: Garamond">Abstract: The chemotaxis system
of bacteria is remarkable for its sensitivity to multiple ligands, over a wide
range of concentrations. These properties rely on cooperativity within clusters
of receptors and on an adaptation system in which chemoreceptors are modified by
methylation/demethylation. I'll discuss recent experiments that reveal new
aspects of adaptation, including "assistance neighborhoods" in which tethered
modifying enzymes can act on multiple receptors, and adaptive variation in the
sizes of receptor clusters.<o:p></o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT face=Garamond size=3><SPAN
style="FONT-SIZE: 12pt; FONT-FAMILY: Garamond"><o:p> </o:p></SPAN></FONT><FONT
face=Garamond size=3><SPAN style="FONT-SIZE: 12pt; FONT-FAMILY: Garamond">Light
refreshments to be served at 2:45 pm<o:p></o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT face=Garamond size=3><SPAN
style="FONT-SIZE: 12pt; FONT-FAMILY: Garamond"><o:p> </o:p></SPAN></FONT><FONT
face=Garamond size=3><SPAN style="FONT-SIZE: 12pt; FONT-FAMILY: Garamond">Host:
Alexander van Oudenaarden, Department of Physics<o:p></o:p></SPAN></FONT></P>
<DIV><FONT face=Arial size=2></FONT> </DIV></BODY></HTML>