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<p class=MsoNormal style='text-autospace:none'><b><font size=5 face=Garamond><span
style='font-size:18.0pt;font-family:Garamond;font-weight:bold'>Spring 2008
Seminar Series on Computational and Systems Biology<o:p></o:p></span></font></b></p>
<p class=MsoNormal style='text-autospace:none'><font size=3 face=Garamond><span
style='font-size:12.0pt;font-family:Garamond'><o:p> </o:p></span></font></p>
<p class=MsoNormal style='text-autospace:none'><font size=3 face=Garamond><span
style='font-size:12.0pt;font-family:Garamond'>Friday, April 25, 2008<o:p></o:p></span></font></p>
<p class=MsoNormal style='text-autospace:none'><font size=3 face=Garamond><span
style='font-size:12.0pt;font-family:Garamond'>3:00 pm – 4:00 pm<o:p></o:p></span></font></p>
<p class=MsoNormal style='text-autospace:none'><font size=3 face=Garamond><span
style='font-size:12.0pt;font-family:Garamond'>Room 3-270<o:p></o:p></span></font></p>
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style='font-size:12.0pt;font-family:Garamond'><o:p> </o:p></span></font></p>
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style='font-size:12.0pt;font-family:Garamond'><o:p> </o:p></span></font></p>
<p class=MsoNormal style='text-autospace:none'><b><i><font size=3
face=Garamond><span style='font-size:12.0pt;font-family:Garamond;font-weight:
bold;font-style:italic'>Presenting:<o:p></o:p></span></font></i></b></p>
<p class=MsoNormal style='text-autospace:none'><font size=3 face=Garamond><span
style='font-size:12.0pt;font-family:Garamond'>Professor Ned Wingreen<o:p></o:p></span></font></p>
<p class=MsoNormal style='text-autospace:none'><font size=3 face=Garamond><span
style='font-size:12.0pt;font-family:Garamond'>Department of Molecular Biology<br>
<st1:place w:st="on"><st1:PlaceName w:st="on">Princeton</st1:PlaceName> <st1:PlaceType
w:st="on">University</st1:PlaceType></st1:place><o:p></o:p></span></font></p>
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style='font-size:12.0pt;font-family:Garamond'><o:p> </o:p></span></font></p>
<p class=MsoNormal style='text-autospace:none'><font size=3 face=Garamond><span
style='font-size:12.0pt;font-family:Garamond'>Title: “<i><span
style='font-style:italic'>Interactome Modeling adaptation in E. coli
chemotaxis: precise, robust, and optimized”</span></i><o:p></o:p></span></font></p>
<p class=MsoNormal style='text-autospace:none'><font size=3 face=Garamond><span
style='font-size:12.0pt;font-family:Garamond'><o:p> </o:p></span></font></p>
<p class=MsoNormal style='text-autospace:none'><font size=3 face=Garamond><span
style='font-size:12.0pt;font-family:Garamond'>Abstract: The chemotaxis system
of bacteria is remarkable for its sensitivity to multiple ligands, over a wide
range of concentrations. These properties rely on cooperativity within clusters
of receptors and on an adaptation system in which chemoreceptors are modified
by methylation/demethylation. I'll discuss recent experiments that reveal new
aspects of adaptation, including "assistance neighborhoods" in which
tethered modifying enzymes can act on multiple receptors, and adaptive
variation in the sizes of receptor clusters.<o:p></o:p></span></font></p>
<p class=MsoNormal style='text-autospace:none'><font size=3 face=Garamond><span
style='font-size:12.0pt;font-family:Garamond'><o:p> </o:p></span></font></p>
<p class=MsoNormal style='text-autospace:none'><font size=3 face=Garamond><span
style='font-size:12.0pt;font-family:Garamond'>Light refreshments to be served
at 2:45 pm<o:p></o:p></span></font></p>
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style='font-size:12.0pt;font-family:Garamond'><o:p> </o:p></span></font></p>
<p class=MsoNormal style='text-autospace:none'><font size=3 face=Garamond><span
style='font-size:12.0pt;font-family:Garamond'>Host: Alexander van Oudenaarden,
Department of Physics<o:p></o:p></span></font></p>
<p class=MsoNormal><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'><o:p> </o:p></span></font></p>
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