<html xmlns:o="urn:schemas-microsoft-com:office:office" xmlns:w="urn:schemas-microsoft-com:office:word" xmlns:st1="urn:schemas-microsoft-com:office:smarttags" xmlns="http://www.w3.org/TR/REC-html40">
<head>
<META HTTP-EQUIV="Content-Type" CONTENT="text/html; charset=us-ascii">
<meta name=Generator content="Microsoft Word 11 (filtered medium)">
<o:SmartTagType namespaceuri="urn:schemas-microsoft-com:office:smarttags"
name="PlaceType"/>
<o:SmartTagType namespaceuri="urn:schemas-microsoft-com:office:smarttags"
name="PlaceName"/>
<o:SmartTagType namespaceuri="urn:schemas-microsoft-com:office:smarttags"
name="place"/>
<!--[if !mso]>
<style>
st1\:*{behavior:url(#default#ieooui) }
</style>
<![endif]-->
<style>
<!--
/* Style Definitions */
p.MsoNormal, li.MsoNormal, div.MsoNormal
{margin:0in;
margin-bottom:.0001pt;
font-size:12.0pt;
font-family:"Times New Roman";}
a:link, span.MsoHyperlink
{color:blue;
text-decoration:underline;}
a:visited, span.MsoHyperlinkFollowed
{color:purple;
text-decoration:underline;}
p
{mso-margin-top-alt:auto;
margin-right:0in;
mso-margin-bottom-alt:auto;
margin-left:0in;
font-size:12.0pt;
font-family:"Times New Roman";}
span.EmailStyle18
{mso-style-type:personal-reply;
font-family:Arial;
color:navy;}
@page Section1
{size:8.5in 11.0in;
margin:1.0in 1.25in 1.0in 1.25in;}
div.Section1
{page:Section1;}
-->
</style>
</head>
<body lang=EN-US link=blue vlink=purple style='word-wrap: break-word;
-khtml-nbsp-mode: space;-khtml-line-break: after-white-space'>
<div class=Section1>
<div>
<p class=MsoNormal><b><font size=3 face="Times New Roman"><span
style='font-size:12.0pt;font-weight:bold'>Spring 2008 Seminar Series on
Computational and Systems Biology<o:p></o:p></span></font></b></p>
</div>
<div>
<p class=MsoNormal><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'>Friday, April 11, 2008<o:p></o:p></span></font></p>
</div>
<div>
<p class=MsoNormal><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'>3:00<span class=apple-style-span><span style='font-variant:small-caps'>
pm</span></span> – 4:00 <span class=apple-style-span><span style='font-variant:
small-caps'>pm</span></span><o:p></o:p></span></font></p>
</div>
<div>
<p class=MsoNormal><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'>Room 3-270<o:p></o:p></span></font></p>
</div>
<div>
<p class=MsoNormal><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'> <o:p></o:p></span></font></p>
<O:P></O:P></div>
<div>
<p class=MsoNormal><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'>Presenting:<o:p></o:p></span></font></p>
</div>
<div>
<p class=MsoNormal><b><font size=3 face="Times New Roman"><span
style='font-size:12.0pt;font-weight:bold'>Dr. Marc Vidal</span></font></b><o:p></o:p></p>
</div>
<div>
<p class=MsoNormal><i><font size=3 face="Times New Roman"><span
style='font-size:12.0pt;font-style:italic'>Dana Farber Cancer Institute and <st1:place
w:st="on"><st1:PlaceName w:st="on">Harvard</st1:PlaceName> <st1:PlaceName
w:st="on">Medical</st1:PlaceName> <st1:PlaceType w:st="on">School</st1:PlaceType>
<st1:PlaceType w:st="on">Center</st1:PlaceType></st1:place> for Cancer Systems
Biology (CCSB) <font color=navy><span style='color:navy'><o:p></o:p></span></font></span></font></i></p>
<O:P></O:P>
<p class=MsoNormal><i><font size=2 color=navy face=Arial><span
style='font-size:10.0pt;font-family:Arial;color:navy;font-style:italic'><o:p> </o:p></span></font></i></p>
</div>
<div>
<p class=MsoNormal><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'>Title: <i><span style='font-style:italic'><a
href="http://csbi.mit.edu:8080/infoglueDeliverWorking/digitalAssets/121_Vidal_CSBiseminar.pdf"><strong><b><font
color=black face="Times New Roman"><span style='color:windowtext;text-decoration:
none'>Interactome Networks and Human Disease</span></font></b></strong></a></span></i><o:p></o:p></span></font></p>
</div>
<div>
<p class=MsoNormal style='text-autospace:none'><font size=3
face="Times New Roman"><span style='font-size:12.0pt'>Abstract: For over half a
century it has been conjectured that macromolecules form complex networks of functionally
interacting components, and that the molecular mechanisms underlying most
biological processes correspond to particular steady states adopted by such
cellular networks. However, until recently, systems-level theoretical
conjectures remained largely unappreciated, mainly because of lack of
supporting experimental data.<o:p></o:p></span></font></p>
<p class=MsoNormal style='text-autospace:none'><font size=3
face="Times New Roman"><span style='font-size:12.0pt'><o:p> </o:p></span></font></p>
<p class=MsoNormal style='text-autospace:none'><font size=3
face="Times New Roman"><span style='font-size:12.0pt'>To generate the
information necessary to eventually address how complex cellular networks relate
to biology, we initiated, at the scale of the whole proteome, an integrated
approach for modeling protein-protein interaction or “interactome” networks.
Our main questions are: How are interactome networks organized at the scale of
the whole cell? How can we uncover local and global features underlying this
organization, and how are interactome networks modified in human disease, such
as cancer?<o:p></o:p></span></font></p>
<p class=MsoNormal><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'> <o:p></o:p></span></font></p>
<O:P></O:P></div>
<div>
<p class=MsoNormal><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'>Light refreshments to be served at 2:45 <span class=apple-style-span><span
style='font-variant:small-caps'>pm</span></span><o:p></o:p></span></font></p>
</div>
<div>
<p class=MsoNormal><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'> <o:p></o:p></span></font></p>
<O:P></O:P></div>
<div>
<p class=MsoNormal><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'>Host:<font color=navy><span style='color:navy'> </span></font>Alexander
van Oudenaarden, Department of Physics<font color=navy><span style='color:navy'><o:p></o:p></span></font></span></font></p>
</div>
</div>
</body>
</html>