<HTML><BODY style="word-wrap: break-word; -khtml-nbsp-mode: space; -khtml-line-break: after-white-space; "><DIV class="MsoNormal"><B>TOMORROW</B></DIV><DIV class="MsoNormal"><BR class="khtml-block-placeholder"></DIV><DIV class="MsoNormal">Spring 2008 Seminar Series on Computational and Systems Biology</DIV><DIV class="MsoNormal">Friday, February 8, 2008</DIV><DIV class="MsoNormal">3:00<SPAN style=""><SPAN class="Apple-style-span" style="font-variant: small-caps;"> pm</SPAN></SPAN> – 4:00 <SPAN style=""><SPAN class="Apple-style-span" style="font-variant: small-caps;">pm</SPAN></SPAN></DIV><DIV class="MsoNormal">Room 3-270</DIV><DIV class="MsoNormal"> <O:P></O:P></DIV><DIV class="MsoNormal">Presenting:</DIV><DIV class="MsoNormal"><B>Dr. Uri Alon</B></DIV><DIV class="MsoNormal"><I>Department of Molecular Cell Biology and Department of Physics of Complex Systems, Weizmann Institute of Science, Rehovot, Israel</I></DIV><DIV class="MsoNormal"> <O:P></O:P></DIV><DIV class="MsoNormal">Title: <B><I>Design Principles of Complex Systems</I></B></DIV><DIV class="MsoNormal">Abstract: Transcriptional networks are made of a collection of recurring interaction patterns known as network motifs.<SPAN style="mso-spacerun: yes"> </SPAN>The same handful of basic circuit elements seems to appear across organisms.<SPAN style="mso-spacerun: yes"> </SPAN>Network motifs are thought to be selected because they carry out specific dynamical functions.<SPAN style="mso-spacerun: yes"> </SPAN>We will describe high-resolution experiments on living cells that demonstrate several such functions of network motifs, including sign-sensitive delays, speedup of network response, pulse generation and temporal programs of gene expression.<SPAN style="mso-spacerun: yes"> </SPAN>We will also describe network motifs in other biological networks, including signaling and neuronal networks.</DIV><DIV class="MsoNormal"> <O:P></O:P></DIV><DIV class="MsoNormal">[See U. Alon, Network motifs: theory and experimental approaches, Nat. Rev. Genetics 8, 450-461 (2007).]</DIV><DIV class="MsoNormal"> <O:P></O:P></DIV><DIV class="MsoNormal">Light refreshments to be served at 2:45 <SPAN style=""><SPAN class="Apple-style-span" style="font-variant: small-caps;">pm</SPAN></SPAN></DIV><DIV class="MsoNormal"> <O:P></O:P></DIV><DIV class="MsoNormal">Hosts:</DIV><DIV class="MsoNormal">Dr. Alexander van Oudenaarden, Department of Physics</DIV><DIV class="MsoNormal">Mei Lyn Ong, Graduate Student, Computational and Systems Biology</DIV><DIV class="MsoNormal"><BR class="khtml-block-placeholder"></DIV></BODY></HTML>