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<blockquote type=cite class=cite cite=""><br><br>
<b>Reminder ! Fall 2007 Seminar Series on Computational and Systems
Biology!</b><br>
<b><br>
Friday, October 12, 2007; 3:00- 4:00 PM, Rm. 4-370<br>
Dr. Gurol Suel<br>
UT Southwestern Medical Cente</b>r<br><br>
Title:<br>
Noisy out of necessity: Probabilistic behavior during cellular
differentiation.<br><br>
Light refreshments to be served at 2:45 p.m.<br><br>
Host: Dr. Alexander van Oudenaarden<br>
Department of Physics<br><br>
Abstract<br><br>
Diverse organisms ranging from bacteria to mammalian stem cells undergo
pluripotent<br>
differentiation where a single cell can commit to one out of several cell
fates.<br>
How do underlying genetic circuits allow cells to "choose" a
specific cell fate and<br>
execute the appropriate differentiation program? To address this question
we investigate<br>
a simple bacterial differentiation system utilizing mathematical modeling
and quantitative<br>
single cell measurements. In particular we are interested in elucidating
the significance<br>
of circuit dynamics and stochastic behavior during cellular
differentiation.<br><br>
Suel et al. Science 315, 1716-1719 (2007)<br>
Suel et al. Nature 440, 545-550 (2006) </blockquote></body>
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