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<body lang="EN-US" link="#467886" vlink="#96607D" style="word-wrap:break-word">
<div class="WordSection1">
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif">Hello,<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif">Please see information below and attached regarding the Advanced Undergraduate Seminars for Fall 2025.<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif"><a href="https://biology.mit.edu/undergraduate/current-students/subject-offerings/advanced-undergraduate-seminars/">https://biology.mit.edu/undergraduate/current-students/subject-offerings/advanced-undergraduate-seminars/</a><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif"><o:p> </o:p></span></p>
<p class="MsoNormal"><b><span style="font-size:14.0pt;font-family:"Calibri",sans-serif;color:#212121">7.341 –<span class="apple-converted-space"> </span><i>Myo-making and Myo-breaking: How Muscles Develop and Change with Exercise, Aging, and Disease, and How
CRISPR Gene-editing Can Be Harnessed to Treat Muscle Disorders</i></span></b><span style="font-size:14.0pt;font-family:"Calibri",sans-serif;color:#212121"><br>
</span><span style="font-size:10.0pt;font-family:"Calibri",sans-serif;color:#212121"><br>
Why do different people excel at different sports? How do differences in genetics and lifestyle affect the development of different muscle groups and muscle fiber types?<o:p></o:p></span></p>
<p class="MsoNormal" style="caret-color: rgb(33, 33, 33);font-variant-caps: normal;orphans: auto;text-align:start;widows: auto;-webkit-text-stroke-width: 0px;word-spacing:0px">
<span style="font-size:10.0pt;font-family:"Calibri",sans-serif;color:#212121"> <o:p></o:p></span></p>
<p class="MsoNormal" style="caret-color: rgb(33, 33, 33);font-variant-caps: normal;orphans: auto;text-align:start;widows: auto;-webkit-text-stroke-width: 0px;word-spacing:0px">
<b><span style="font-size:10.0pt;font-family:"Calibri",sans-serif;color:#212121">Offered:</span></b><span class="apple-converted-space"><span style="font-size:10.0pt;font-family:"Calibri",sans-serif;color:#212121"> </span></span><span style="font-size:10.0pt;font-family:"Calibri",sans-serif;color:#212121">Fall
2025<br>
<b>Tentative Time:</b><span class="apple-converted-space"> </span>Fridays, 2–4 PM<br>
<b>Instructor:</b><span class="apple-converted-space"> </span>Dr. Yichi (Tony) Zhang (Postdoctoral Fellow at Vander Heiden Lab, Koch Institute)<br>
<b>Recommended Prereqs:</b><span class="apple-converted-space"> </span>7.03 or 7.05 (not required)<br>
<b>Open to:</b><span class="apple-converted-space"> </span>All majors and levels at MIT, Harvard, Wellesley<br>
<b>Course Type:</b><span class="apple-converted-space"> </span>Seminar / Journal Club<br>
<b>Cross-Registration Info:</b><span class="apple-converted-space"> </span><a href="https://registrar.mit.edu/registration-academics/registration-information/cross-registration" target="_new" title="https://registrar.mit.edu/registration-academics/registration-information/cross-registration"><span style="font-family:"Aptos",sans-serif;color:#96607D">MIT
Registrar Link</span></a><o:p></o:p></span></p>
<p class="MsoNormal" style="caret-color: rgb(33, 33, 33);font-variant-caps: normal;orphans: auto;text-align:start;widows: auto;-webkit-text-stroke-width: 0px;word-spacing:0px">
<span style="font-size:10.0pt;font-family:"Calibri",sans-serif;color:#212121"> <o:p></o:p></span></p>
<p class="MsoNormal" style="caret-color: rgb(33, 33, 33);font-variant-caps: normal;orphans: auto;text-align:start;widows: auto;-webkit-text-stroke-width: 0px;word-spacing:0px">
<b><span style="font-size:10.0pt;font-family:"Calibri",sans-serif;color:#212121">Topics Covered:</span></b><span style="font-size:10.0pt;font-family:"Calibri",sans-serif;color:#212121"><o:p></o:p></span></p>
<ul style="margin-top:0in;caret-color: rgb(33, 33, 33);font-variant-caps: normal;orphans: auto;text-align:start;widows: auto;-webkit-text-stroke-width: 0px;word-spacing:0px" type="disc">
<li class="MsoListParagraph" style="color:#212121;margin-top:0in;margin-bottom:0in;mso-list:l5 level1 lfo3">
Muscle biology: development, structure, function, and adaptation<o:p></o:p></li><li class="MsoListParagraph" style="color:#212121;margin-top:0in;margin-bottom:0in;mso-list:l5 level1 lfo3">
Genetics vs. lifestyle: how they affect muscle groups and fiber types<o:p></o:p></li><li class="MsoListParagraph" style="color:#212121;margin-top:0in;margin-bottom:0in;mso-list:l5 level1 lfo3">
CRISPR gene-editing: potential for therapeutic applications<o:p></o:p></li><li class="MsoListParagraph" style="color:#212121;margin-top:0in;margin-bottom:0in;mso-list:l5 level1 lfo3">
Diseases: muscular dystrophies and age-related muscle decline<o:p></o:p></li><li class="MsoListParagraph" style="color:#212121;margin-top:0in;margin-bottom:0in;mso-list:l5 level1 lfo3">
Therapeutic design: delivery, specificity, and gene regulation<o:p></o:p></li></ul>
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<b><span style="font-size:10.0pt;font-family:"Calibri",sans-serif;color:#212121">What You’ll Gain:</span></b><span style="font-size:10.0pt;font-family:"Calibri",sans-serif;color:#212121"><o:p></o:p></span></p>
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Critical reading of primary scientific literature<o:p></o:p></li><li class="MsoListParagraph" style="color:#212121;margin-top:0in;margin-bottom:0in;mso-list:l4 level1 lfo6">
Skills in:<o:p></o:p></li></ul>
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Interpreting experimental data<o:p></o:p></li><li class="MsoListParagraph" style="color:#212121;margin-top:0in;margin-bottom:0in;mso-list:l3 level2 lfo9">
Designing<span class="apple-converted-space"> </span><strong><span style="font-family:"Aptos",sans-serif;font-weight:normal">rigorous experiments</span></strong><span class="apple-converted-space"> </span>with proper controls<o:p></o:p></li><li class="MsoListParagraph" style="color:#212121;margin-top:0in;margin-bottom:0in;mso-list:l3 level2 lfo9">
Scientific<span class="apple-converted-space"> </span><strong><span style="font-family:"Aptos",sans-serif;font-weight:normal">writing</span></strong><span class="apple-converted-space"> </span>and<span class="apple-converted-space"> </span><strong><span style="font-family:"Aptos",sans-serif;font-weight:normal">oral
presentation</span></strong><o:p></o:p></li><li class="MsoListParagraph" style="color:#212121;margin-top:0in;margin-bottom:0in;mso-list:l3 level2 lfo9">
Critiquing scientific findings and reasoning<o:p></o:p></li></ul>
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<span style="font-size:10.0pt;font-family:"Calibri",sans-serif;color:#212121"> <o:p></o:p></span></p>
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<b><span style="font-size:10.0pt;font-family:"Calibri",sans-serif;color:#212121">Special Feature:</span></b><span style="font-size:10.0pt;font-family:"Calibri",sans-serif;color:#212121"><o:p></o:p></span></p>
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<b><span style="font-size:10.0pt;font-family:"Calibri",sans-serif;color:#212121">Guided tour of Vertex Pharmaceuticals<br>
</span></b><span style="font-size:10.0pt;font-family:"Calibri",sans-serif;color:#212121">Led by Dr. Yi-li Min, senior scientist working on CRISPR gene therapy for Duchenne Muscular Dystrophy, including Q&A with students.<o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;mso-ligatures:none">*****<o:p></o:p></span></p>
<p class="MsoNormal"><b><span style="font-size:14.0pt;font-family:"Calibri",sans-serif;color:#212121">Fall 2025 Course Offering: The Biology of Regeneration (7.342):</span></b><span style="font-size:14.0pt;font-family:"Calibri",sans-serif;color:#212121"><o:p></o:p></span></p>
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<span style="font-size:10.0pt;font-family:"Calibri",sans-serif;color:#212121">We are excited to announce that this fall, we will be offering 7.342: The Biology of Regeneration from Wound-Healing to Whole-Organism: Molecular, Cellular, Developmental, and Evolutionary
Principles and Their Biomedical Applications.<br>
<br>
Why can some organisms regrow complex body parts while others cannot? How do regenerative processes compare to embryonic development, and how can insights from nature inspire biomedical advances?<br>
<br>
This course explores the molecular, cellular, and developmental principles of regeneration, spanning from wound closure to whole-organism regrowth. We will discuss diverse models, including planarians, axolotls, fish, mollusks, plants, and mammals, as well
as current translational approaches in regenerative medicine.<br>
<br>
Students will learn to critically analyze scientific papers, engage in discussion-based learning, and gain exposure to cutting-edge methods in regenerative biology.<br>
<br>
The course will also include unique opportunities such as:<br>
• A field trip to a biotechnology company (Elevate Bio)<br>
• A laboratory visit to observe and work with regenerative species in the Reddien Lab at the Whitehead Institute<br>
<br>
All backgrounds are welcome. If you are interested in joining, please register through the MIT course system. For questions, feel free to reach out to us directly.<br>
<br>
We look forward to an engaging semester exploring the frontiers of regeneration!<br>
<br>
Instructors: Luiza Saad, PhD (<a href="mailto:lsaad@wi.mit.edu" target="_blank" title="mailto:lsaad@wi.mit.edu"><span style="color:#0078D7">lsaad@wi.mit.edu</span></a>) & Kutay Deniz Atabay, PhD (<a href="mailto:kdatabay@mit.edu" target="_blank" title="mailto:kdatabay@mit.edu"><span style="color:#0078D7">kdatabay@mit.edu</span></a>),
Whitehead Institute<br>
Schedule: Thursdays, 11 am – 1 pm (final day/time will be adjusted based on student availability)<o:p></o:p></span></p>
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