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<p class="MsoNormal">Begin forwarded message:<o:p></o:p></p>
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<p class="MsoNormal"><b><span style="font-family:"Helvetica Neue"">From: </span></b><span style="font-family:"Helvetica Neue"">Jianzhu Chen <jchen@mit.edu></span><o:p></o:p></p>
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<p class="MsoNormal"><b><span style="font-family:"Helvetica Neue"">Subject: MIT 7.371 Teaching Assistant</span></b><o:p></o:p></p>
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<p class="MsoNormal"><b><span style="font-family:"Helvetica Neue"">Date: </span></b><span style="font-family:"Helvetica Neue"">August 5, 2024 at 12:19:44 PM EDT</span><o:p></o:p></p>
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<p class="MsoNormal"><b><span style="font-family:"Helvetica Neue"">Cc: </span></b><span style="font-family:"Helvetica Neue"">"lodish@wi.mit.edu" <lodish@wi.mit.edu></span><o:p></o:p></p>
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<p class="MsoNormal"><o:p> </o:p></p>
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<p class="MsoNormal" align="center" style="text-align:center"><span style="font-size:16.0pt;font-family:"Arial",sans-serif">LEARN MODERN BIOTECHNOLGY<o:p></o:p></span></p>
<p class="MsoNormal" align="center" style="text-align:center"><span style="font-size:16.0pt;font-family:"Arial",sans-serif">AND DEVELOP IMPORTANT TEACHING SKILLS<o:p></o:p></span></p>
<p class="MsoNormal" align="center" style="text-align:center"><span style="font-family:"Arial",sans-serif"><o:p> </o:p></span></p>
<p class="MsoNormal" align="center" style="text-align:center"><span style="font-family:"Arial",sans-serif">Become the Teaching Associate in
</span><span style="font-family:"Arial",sans-serif;color:black">7.371, <o:p></o:p></span></p>
<p class="MsoNormal" align="center" style="text-align:center"><span style="font-family:"Arial",sans-serif;color:black"> </span><span style="font-family:"Arial",sans-serif;color:black">Biological and Engineering Principles Underlying Novel Biotherapeutics<o:p></o:p></span></p>
<p class="MsoNormal" align="center" style="text-align:center"><span style="font-family:"Arial",sans-serif;color:black"><o:p> </o:p></span></p>
<p class="MsoNormal" align="center" style="text-align:center"><span style="font-family:"Arial",sans-serif;color:black">The class meets
</span><span style="font-family:"Arial",sans-serif;color:black">Mondays and Wednesdays, 3:00 – 5:00, during the Fall Term in the Whitehead Institute 7<sup>th</sup> floor classroom<o:p></o:p></span></p>
<p class="MsoNormal" align="center" style="text-align:center"><span style="font-family:"Arial",sans-serif;color:black"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-family:"Arial",sans-serif;color:black">This is a seminar and paper-reading course for ~15 senior MIT undergraduates who have already taken Genetics, Cell Biology, and Biochemistry and who have had extensive laboratory
experiences. We read and discuss key basic and clinical research papers underlying many of the recent advances in biotechnology, and the course is taught at a very high level.
<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-family:"Arial",sans-serif;color:black"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-family:"Arial",sans-serif;color:black">Topics this fall will include:<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-family:"Arial",sans-serif;color:black"><o:p> </o:p></span></p>
<ul style="margin-top:0in" type="disc">
<li class="MsoListParagraphCxSpFirst" style="color:black;margin-left:9.35pt;mso-add-space:auto;mso-list:l0 level1 lfo1">
<span style="font-family:"Arial",sans-serif">Therapeutic recombinant proteins <o:p>
</o:p></span></li><li class="MsoListParagraphCxSpMiddle" style="color:black;margin-left:9.35pt;mso-add-space:auto;mso-list:l0 level1 lfo1">
<span style="font-family:"Arial",sans-serif">AAV gene therapies and directed evolution of AAV capsids for cell-specific gene delivery<o:p></o:p></span></li><li class="MsoListParagraphCxSpMiddle" style="color:black;margin-left:9.35pt;mso-add-space:auto;mso-list:l0 level1 lfo1">
<span style="font-family:"Arial",sans-serif">Oligonucleotide therapies for protein inhibition and for splicing activation
<o:p></o:p></span></li><li class="MsoListParagraphCxSpMiddle" style="color:black;margin-left:9.35pt;mso-add-space:auto;mso-list:l0 level1 lfo1">
<span style="font-family:"Arial",sans-serif">CRSPR and Base Editing therapies </span>
<span style="font-family:"Arial",sans-serif">for beta-thalassemia and sickle cell disease</span><span style="font-family:"Arial",sans-serif"><o:p></o:p></span></li><li class="MsoListParagraphCxSpMiddle" style="color:black;margin-left:9.35pt;mso-add-space:auto;mso-list:l0 level1 lfo1">
<span style="font-family:"Arial",sans-serif">Retroviral vector therapies for immune disorders<o:p></o:p></span></li><li class="MsoListParagraphCxSpMiddle" style="color:black;margin-left:9.35pt;mso-add-space:auto;mso-list:l0 level1 lfo1">
<span style="font-family:"Arial",sans-serif">Monoclonal antibodies</span><span style="font-family:"Arial",sans-serif"> and antibody therapeutics: Anti-TNF therapeutics for rheumatoid arthritis</span><span style="font-family:"Arial",sans-serif"> and anti-IgE
for treating allergy and asthma<o:p></o:p></span></li><li class="MsoListParagraphCxSpMiddle" style="color:black;margin-left:9.35pt;mso-add-space:auto;mso-list:l0 level1 lfo1">
<span style="font-family:"Arial",sans-serif">Antibody-drug conjugates</span><span style="font-family:"Arial",sans-serif">
<o:p></o:p></span></li><li class="MsoListParagraphCxSpMiddle" style="color:black;margin-left:9.35pt;mso-add-space:auto;mso-list:l0 level1 lfo1">
<span style="font-family:"Arial",sans-serif">Cancer immunotherapy: Checkpoint inhibitors, CAR-T cells, and cancer vaccines<o:p></o:p></span></li><li class="MsoListParagraphCxSpMiddle" style="color:black;margin-left:9.35pt;mso-add-space:auto;mso-list:l0 level1 lfo1">
<span style="font-family:"Arial",sans-serif">Microbiome and its applications<o:p></o:p></span></li><li class="MsoListParagraphCxSpMiddle" style="color:black;margin-left:9.35pt;mso-add-space:auto;mso-list:l0 level1 lfo1">
<span style="font-family:"Arial",sans-serif">iPS- derived cell therapies: Pancreatic islets and cardiomyocytes</span><span style="font-family:"Arial",sans-serif"><o:p></o:p></span></li></ul>
<p class="MsoListParagraphCxSpLast" style="margin-left:45.35pt;mso-add-space:auto;text-indent:-.25in;mso-list:l0 level1 lfo1">
<![if !supportLists]><span style="font-family:Symbol;color:black"><span style="mso-list:Ignore">·<span style="font:7.0pt "Times New Roman"">
</span></span></span><![endif]><span style="font-family:"Arial",sans-serif;color:black">Ultrasensitive DNA and RNA diagnostics</span><span style="font-family:"Arial",sans-serif;color:black"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-family:"Arial",sans-serif;color:black"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-family:"Arial",sans-serif;color:black">Responsibilities include helping evaluate student class participation; joining in all class discussions; teaching one or more classes using papers of your choosing; working with students
to develop their final class project; and helping evaluate the written and oral final projects.
<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-family:"Arial",sans-serif;color:black"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-family:"Arial",sans-serif;color:black">If interested please contact either Professor Jianzhu Chen (</span><a href="mailto:jchen@mit.edu"><span style="font-family:"Arial",sans-serif">jchen@mit.edu</span></a><span style="font-family:"Arial",sans-serif;color:black">)
or Harvey Lodish (</span><a href="mailto:lodish@wi.mit.edu"><span style="font-family:"Arial",sans-serif">lodish@wi.mit.edu</span></a><span style="font-family:"Arial",sans-serif;color:black">)<o:p></o:p></span></p>
<p class="MsoNormal"><o:p> </o:p></p>
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