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<p class="MsoNormal"><b><span style="font-size:12.0pt;color:black">From: </span></b><span style="font-size:12.0pt;color:black">"Marneros, Alexander G.,M.D.,Ph.D." <AMARNEROS@mgh.harvard.edu><br>
<b>Subject: </b>research technician position in my lab at MGH/Harvard Medical School<o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:11.0pt">Alexander G. Marneros, MD/PhD</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt">Associate Professor of Dermatology, Harvard Medical School</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt">Cutaneous Biology Research Center</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt">Massachusetts General Hospital</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt">Email: amarneros@mgh.harvard.edu</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt"> </span><o:p></o:p></p>
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<b><span style="font-family:"Times New Roman",serif;color:black">Research technician position (Research Assistant I) in Angiogenesis/Immunology/Wound healing at Harvard/MGH</span></b><o:p></o:p></p>
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<b><span style="font-family:"Times New Roman",serif;color:black">Laboratory of Angiogenesis and Inflammation, Dr. Alexander G. Marneros,
</span></b><o:p></o:p></p>
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<b><span style="font-family:"Times New Roman",serif;color:black">Cutaneous Biology Research Center, Department of Dermatology,
</span></b><o:p></o:p></p>
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<b><span style="font-family:"Times New Roman",serif;color:black">Massachusetts General Hospital/Harvard Medical School, Boston</span></b><o:p></o:p></p>
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<b><span style="font-family:"Times New Roman",serif;color:black"> </span></b><o:p></o:p></p>
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<span style="font-size:11.0pt;font-family:"Times New Roman",serif;color:black">Our laboratory is investigating molecular mechanisms involved in
<b>wound healing, angiogenesis and inflammation</b>.</span><o:p></o:p></p>
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<u><span style="font-size:11.0pt;font-family:"Times New Roman",serif;color:black">Project 1:</span></u><span style="font-size:11.0pt;font-family:"Times New Roman",serif;color:black"> We are investigating
<b>molecular mechanisms that control macrophage activation and the role that activated macrophages play for inflammation and pathological angiogenesis</b>. We have established
<i>in vitro</i> assays to identify regulators of macrophage polarization. In chemical screens we could identify pharmacologic inhibitors of alternative macrophage polarization (M2-type macrophages) and could show
<i>in vivo</i> that these inhibitors can block macrophage-induced angiogenesis (<b><i>Cell Reports</i></b>,
<b><i>2013; JBC, 2014; Cell Reports 2021</i></b>). This project aims to define molecular pathways that are critical for macrophage polarization and that influence the ability of activated macrophages to induce pathological angiogenesis in conditions such as
age-related macular degeneration, cancer or wound healing.</span><o:p></o:p></p>
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<u><span style="font-size:11.0pt;font-family:"Times New Roman",serif;color:black">Project 2:</span></u><span style="font-size:11.0pt;font-family:"Times New Roman",serif;color:black"> We investigate
<b>the role of proangiogenic factors for wound healing and age-related diseases</b>. We could show that the proangiogenic factor VEGF-A induces oxidative stress and NLRP3 inflammasome activation to promote age-related diseases
<b><i>(Cell Reports, 2013; FASEB J, 2014; EMBO Mol Med, 2016; FASEB J, 2018, eLife, 2020)</i>.
</b>We use a variety of <i>in vivo</i> and <i>in vitro</i> approaches to investigate a
<b>novel pathogenic link between VEGF-A and NLRP3 inflammasome activation</b>.</span><o:p></o:p></p>
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<u><span style="font-size:11.0pt;font-family:"Times New Roman",serif;color:black">Project 3:</span></u><span style="font-size:11.0pt;font-family:"Times New Roman",serif;color:black"> We identified a novel pathway that is critical for epithelial differentiation,
especially in the kidney. This AP-2b/KCTD1 pathway plays a critical role in kidney development and for renal function in the adult. We use mouse genetics to elucidate the role of this pathway for kidney functions
<b><i>(Dev Cell, 2020; Cell Reports, 2021)</i></b>.</span><o:p></o:p></p>
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<span style="font-size:11.0pt;font-family:"Times New Roman",serif;color:black">In summary, our laboratory uses a large number of diverse experimental approaches (human genetics, mouse genetics, chemical screens,
<i>in vitro</i> assays, cutting-edge imaging technology) to define novel mechanisms in angiogenesis, wound healing and inflammation. All of our projects have strong translational clinical relevance.</span><o:p></o:p></p>
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<span style="font-size:11.0pt;font-family:"Times New Roman",serif;color:black">Our laboratory is embedded in a highly productive and well-equipped environment at the Cutaneous Biology Research Center of Massachusetts General Hospital/Harvard Medical School.
Cutting-edge technologies are available within our Department and the MGH/Harvard research community.</span><o:p></o:p></p>
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<u><span style="font-size:11.0pt;font-family:"Times New Roman",serif;color:black">Required profile:</span></u><o:p></o:p></p>
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<span style="font-size:11.0pt;font-family:"Times New Roman",serif;color:black">- Passionate about science and commitment for ~1 year required</span><o:p></o:p></p>
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<span style="font-size:11.0pt;font-family:"Times New Roman",serif;color:black">- prior laboratory experience, especially working with mice, preferred
</span><o:p></o:p></p>
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<span style="font-size:11.0pt;font-family:"Times New Roman",serif;color:black">- applicants must be reliable, well organized and have good log-keeping abilities</span><o:p></o:p></p>
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<span style="font-size:11.0pt;font-family:"Times New Roman",serif;color:black">- Position start date: ASAP</span><o:p></o:p></p>
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<span style="font-size:11.0pt;font-family:"Times New Roman",serif;color:red">lab website: https://www.massgeneral.org/dermatology/research/cutaneous-biology-research-center/faculty-labs/alexander-marneros-lab</span><o:p></o:p></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-size:11.0pt;font-family:"Times New Roman",serif;color:black">Interested candidates should send the CV and references to Alexander G. Marneros, M.D., Ph.D.,
</span><o:p></o:p></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-size:11.0pt;font-family:"Times New Roman",serif;color:black">Email:
<b>amarneros@mgh.harvard.edu</b> </span><o:p></o:p></p>
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