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<p class="MsoNormal"><b><span style="font-size:12.0pt;color:black">From: </span></b><span style="font-size:12.0pt;color:black">Mary Anne Donovan <donovan@wi.mit.edu><br>
<b>Subject: </b>Fwd: Seminar at Whitehead by eminent Irish scientist<o:p></o:p></span></p>
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<p class="MsoNormal">Please see attached seminar poster hosted by Professor Rick Young. Friday, March 11 at 2pm.<o:p></o:p></p>
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<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal" align="center" style="text-align:center"><b><span lang="EN-IE" style="font-size:14.0pt;color:black;mso-fareast-language:ZH-CN">Bats: Longevity, immunity, genomes… why should we care?</span></b><b><span lang="EN-IE" style="font-size:14.0pt;font-family:"Times New Roman",serif;mso-fareast-language:ZH-CN"><o:p></o:p></span></b></p>
<p class="MsoNormal" align="center" style="text-align:center"><b><span lang="EN-IE" style="font-size:16.0pt;mso-fareast-language:ZH-CN"><o:p> </o:p></span></b></p>
<p class="MsoNormal" align="center" style="text-align:center">Prof. Emma C. Teeling,<span lang="EN-GB" style="font-size:12.0pt;mso-fareast-language:EN-GB"><o:p></o:p></span></p>
<p class="MsoNormal" align="center" style="text-align:center">School of Biology and Environmental Science, University College Dublin, Ireland<o:p></o:p></p>
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<p class="MsoNormal" style="text-align:justify">Of all mammals, bat possess the most unique and peculiar adaptations that render them as excellent models to investigate the mechanisms of extended longevity and potentially halted senescence. Indeed, they are
the longest-lived mammals relative to their body size, with the oldest bat caught being >41 years old, living approx. 8 times longer than expected.<sup>
</sup>Bats defy the ‘rate-of-living’ theories that propose a positive correlation between body size and longevity as they use twice the energy as other species of considerable size, but live far longer. The mechanisms that bats use to avoid the negative physiological
effects of their heightened metabolism and deal with an increased production of deleterious Reactive Oxygen Species (ROS) is not known, however it is suggested that they either prevent or repair ROS damage. Bats also appear to have resistance to many viral
diseases such as rabies, SARS and Ebola-like viruses and are the suspected reservoir species for a huge diversity of newly discovered viruses, including Sars-CoV-2 This<sup>
</sup>suggests that their innate immunity is different to other mammals, perhaps playing a role in their unexpected longevity. Here the potential genomic basis for their rare immunity and exceptional longevity is explored across multiple bat genomes and divergent
ageing and immune related markers (e.g. microbiome, telomeres, mitochondria, cellular dynamics, cytokine response) studied in wild bat populations. These findings provide a deeper understanding of the causal mechanisms of ageing and tolerant immunity, potentially
uncovering the key molecular pathways that could be utilised to benefit society.
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<p class="MsoNormal"><span style="font-size:11.5pt;font-family:Helvetica">Prof. Emma Teeling MRIA<o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:11.5pt;font-family:Helvetica">Full Professor, Head of Zoology<o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:11.5pt;font-family:Helvetica">Founding Director Bat1K / IRC Laureate<o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:11.5pt;font-family:Helvetica">UCD School of Biology and Environmental Science<br>
Science Centre West<br>
University College Dublin<br>
Belfield, Dublin 4<br>
Ireland<br>
Tel: +353 1 716 2263<br>
<a href="mailto:emma.teeling@ucd.ie" target="_blank">email: emma.teeling@ucd.ie</a><br>
<a href="http://batlab.ucd.ie/" target="_blank">http://batlab.ucd.ie/</a><o:p></o:p></span></p>
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